Cryptosporioptide: A bioactive polyketide produced by an endophytic fungus Cryptosporiopsis sp.

A New Polyketide from the Endophytic Fungus <i>Penicillium chermesinum</i>

“…3 and 4) as follows: from 9-OCH3 (δH 3.91),H-10 (δH7. 19), and H-8 (δH6.66) to C-9 (δC166.0); H-8 (δH 6.66) to C-9 (δC166.0); and 1-CH3 (δH 2.74) to C-1 (δC 124.1), C-2 (δC 119.9), and C-10b (δC 110.1); and H-8 (δH 6.66) to C-7 (δC 163.9) as well as the NOESY correlations (Fig. 4) of H-8/H-10/9-OCH3 and H-10/1-Me.…”

“…Other polyketides were isolated from endophytic fungi which isolated from mangrove and medicinal plants [13][14][15]. They have been reported to exhibited antibacterial, anticancer, and antifungal activities [16][17][18][19]. Recently, we reported the isolation of four new polyketides, penicilliumulides A-D, one new eremophilane sesquiterpene together with three known compounds, TMC-264, PR-toxin, and eremofortine C, from the mangrove derived endophytic fungus Penicillium chermesinum.…”

α-Glucosidase and lipoxygenase inhibitory derivatives of cryptosporioptide from the endophytic fungusCryptosporiopsissp.

“…Cryptosporioptide A (2) was obtained as yellow amorphous powder, whose molecular formula ( [1], with the only one difference being that the NMR spectra of compound 2 were without the methoxyl group in compound 1, and thus 2 possessed a carboxylic acid function instead of methyl carboxylate in the reference compound 1.…”

“…Previously, we isolated a novel antibiotic polyketide cryptosporioptide (1, Figure 1) from the culture extract of the endophytic fungus Cryptosporiopsis sp., along with some minor un-identified compounds [1]. Re-culturing of the same fungus and purification of the culture extract yielded two new derivatives of cryptosporioptide: cryptosporioptides A (2) and B (3).…”

Endophytic Fungi as a Source of Novel Metabolites

“…Its biological activities were assessed and compound 322 showed significant lipoxygenase inhibitory activity, while it was inactive against acetylcholinesterase and butyrylcholinesterase. In the antimicrobial assays, compound 322 was active against Bacillus megaterium, but inactive against the bacteria E. coli, the fungi Microbotyrum violaceum and Botrytis cinerea, and the alga Chlorella fusca [89].…”