Cryptosporidium parvum

Dumaine, Jennifer E.; Tandel, Jayesh; Striepen, Boris

doi:10.1016/j.pt.2019.11.003

Cited by 29 publications

(24 citation statements)

References 11 publications

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“…Currently, there is no vaccine, and Nitazoxanide (NTZ) is the standard drug for cryptosporidiosis [ 19 ]. Previous studies have found that many plants such as Euphorbia hirta , Ficus carica and Ficus religiosa exerted antiparasitic, antiprotozoal, molluscicidal and insecticidal effects [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Anticryptosporidium Efficacy of Olea europaea and Ficus carica Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System

El-Hamed

Yousef

Mazrou

et al. 2021

Cells

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Cryptosporidiosis is caused by an opportunistic protozoan parasite (Cryptosporidium parvum and C. hominis) known as a parasite of humans, especially children and immunocompromised patients. The current study was designed to evaluate the therapeutic efficacy of a mixture of fig and olive leaf extracts as an alternative medicinal plant. Parasitological examination for oocysts in the stool and histopathological alterations in the small intestines were examined. Additionally, biochemical analyses of liver and kidney functions in addition to antioxidant parameters such as superoxide dismutase (SOD), glutathione peroxidase (GSH) and catalase (CAT) in the plasma were evaluated. Our results showed that marked reduction in oocysts shedding and amelioration in intestinal histopathological changes and hepatic or renal functions were detected in all treated groups compared to the control infected group. Additionally, the treated groups with tested extracts at ratios 1:3 and 1:5 showed a significant decrease in the number of oocysts compared to the other treated groups. Results exhibited a significant increase in the plasma SOD, CAT and GSH levels in treated groups compared to the infected control one. This study suggested that a mixture of fig and olive leaf extracts is a convenient promising therapeutic agent for Cryptosporidiosis.

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Section: Introductionmentioning

confidence: 99%

Anticryptosporidium Efficacy of Olea europaea and Ficus carica Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System

El-Hamed

Yousef

Mazrou

et al. 2021

Cells

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“…The genus Cryptosporidium is composed of protozoan parasites that infect the gastrointestinal epithelium and other mucosal surfaces of their host, including humans (Vanathy et al 2017 ). Transmission occurs through the fecal−oral path, and sources of infection with Cryptosporidium include contaminated food or water (Dumaine et al 2019 ). Human cryptosporidial infections have been related mainly to C. parvum and the severity of infection may range from an asymptomatic shedding of ingested oocysts to a serious life-threatening, and prolonged disease (Ryan et al 2014 ; Lender et al 2015 ).…”

Section: Mirnas: Fine Modulators Of Parasitic Infectionsmentioning

confidence: 99%

Human microRNAs in host–parasite interaction: a review

et al. 2020

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MicroRNAs (miRNAs) are a group of small noncoding RNA molecules with significant capacity to regulate the gene expression at the post-transcriptional level in a sequence-specific manner either through translation repression or mRNA degradation triggering a fine-tuning biological impact. They have been implicated in several processes, including cell growth and development, signal transduction, cell proliferation and differentiation, metabolism, apoptosis, inflammation, and immune response modulation. However, over the last few years, extensive studies have shown the relevance of miRNAs in human pathophysiology. Common human parasitic diseases, such as Malaria, Leishmaniasis, Amoebiasis, Chagas disease, Schistosomiasis, Toxoplasmosis, Cryptosporidiosis, Clonorchiasis, and Echinococcosis are the leading cause of death worldwide. Thus, identifying and characterizing parasite-specific miRNAs and their host targets, as well as host-related miRNAs, are important for a deeper understanding of the pathophysiology of parasite-specific diseases at the molecular level. In this review, we have demonstrated the impact of human microRNAs during host−parasite interaction as well as their potential to be used for diagnosis and prognosis purposes.

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“…can mean not only severe diarrhea but also death in patients with HIV/AIDS, patients who have received an organ transplant, and patients on immunosuppressants [6]. So far, no effective vaccines are available to prevent cryptosporidiosis in humans or in livestock [7]. Prevention and control measures are therefore essential for the protection of vulnerable groups, such as young children and severely immunocompromised individuals, as there are only a few safe and effective therapeutic options available.…”

Section: Introductionmentioning

confidence: 99%

Molecular Epidemiology of Cryptosporidium spp. in an Agricultural Area of Northern Vietnam: A Community Survey

Iwashita

Takemura²,

Tokizawa

et al. 2020

Preprint

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BackgroundCryptosporidium spp. is a protozoan parasite with worldwide distribution that causes cryptosporidiosis in humans and other animals. In the countryside of northern Vietnam, where free-roaming livestock are widespread, cryptosporidiosis is an important zoonotic disease. However, there have been few studies of cryptosporidiosis in Southeast Asia from the perspective of zoonotic disease epidemiology. The purpose of this study was to investigate the occurrence of Cryptosporidium infection in both humans and animals and to gain an awareness of the potential threat posed by this zoonotic infection in northern Vietnam.Methods We conducted a community survey to collect information about cases of diarrhea in an agricultural area of northern Vietnam. For this study, a total of 2715 samples (2120 human diarrheal samples, 471 non-diarrheal human samples, and 124 animal stool samples) were collected. A direct immunofluorescence assay (DFA) was used to detect Cryptosporidium spp. oocysts in concentrated stool samples by observation under a fluorescent microscope. DNA extraction, PCR amplification of the three genes (COWP, SSU-rRNA, and GP60), and sequencing analysis were performed to identify Cryptosporidium spp.Results Of 2715 samples, 15 samples (10 diarrheal samples, 2 non-diarrheal samples, and 3 animal stool samples) tested positive by PCR for the COWP gene. Three species of Cryptosporidium spp. were detected; C. canis (from six human diarrheal samples, two human non-diarrheal samples, and one dog sample); C. hominis (from four human diarrheal samples); and C. suis (from two pig samples). In terms of C. hominis, the GP60 subtype IeA12G3T3 was detected in all four human diarrheal samples.Conclusions Although the number of positive samples was very small, our epidemiological data showed that the emerging pattern of each of the three species (C. canis, C. hominis, and C. suis) was different at this study site. For example, zoonotic transmission of C. canis, between dogs and humans was suspected. Further studies are needed to assess the risk of oocyst contamination in the wider environment, including water, in this study area.

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Cryptosporidium parvum

Cited by 29 publications

References 11 publications

Anticryptosporidium Efficacy of Olea europaea and Ficus carica Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System

Anticryptosporidium Efficacy of Olea europaea and Ficus carica Leaves Extract in Immunocompromised Mice Associated with Biochemical Characters and Antioxidative System

Human microRNAs in host–parasite interaction: a review

Molecular Epidemiology of Cryptosporidium spp. in an Agricultural Area of Northern Vietnam: A Community Survey

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