Cryptosporidium andersoni as a novel predominant Cryptosporidium species in outpatients with diarrhea in Jiangsu Province, China

Jiang, Yanyan; Ren, Jinhua; Yuan, Zhongying; Liu, Aiqin; Zhao, Hong; Liu, Hua; Chu, Lei; Pan, Wei; Cao, Jianping; Lin, Yijin; Shen, Yujuan

doi:10.1186/s12879-014-0555-7

Cited by 61 publications

(50 citation statements)

References 40 publications

(49 reference statements)

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“…C. andersoni is a gastric parasite which has been associated with reduced milk yield in dairy cattle and decreased weight gain in post weaned calves (Olson et al 2004) and is occasionally detected in humans (Leoni et al, 2006;Morse et al, 2007;Waldron et al, 2011;Agholi et al, 2013;Jiang et al, 2014;Liu et al, 2014). Two studies in China by the same research group have reported that C. andersoni was the most prevalent Cryptosporidium species detected in humans Liu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Genetic characterization of Cryptosporidium in animal and human isolates from Jordan

Hijjawi

Mukbel

Yang

et al. 2016

Veterinary Parasitology

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(Mukbel R). #Joint first authors Highlights First genotyping study of Cryptosporidium in animals in Jordan  Faecal samples (n=284) from domestic animals and humans (n=48) screened  Overall prevalence of 11.6% in animals and six species detected.  Novel Cryptosporidium genotype detected in horses AbstractLittle is known about the epidemiology of Cryptosporidium in Jordan and to date, only one genotyping study has been conducted on Cryptosporidium isolates from Jordanian children. In the present study, a total of 284 faecal samples from Jordanian cattle, sheep, goats and chicken and 48 human faecal samples were screened for the presence of Cryptosporidium using an 18S quantitative PCR (qPCR) and a C. parvum/C. hominis specific qPCR at a lectin locus. Of these, 37 of 284 animal faecal samples were positive by qPCR at the 18S locus giving an overall prevalence of 11.6%. The point prevalence of Cryptosporidium in chickens, sheep, horses, cattle and goats ranged from 4.8% (chickens) to 18.7% (cattle). A total of six species were detected; C. xiaoi (n=9), C.andersoni (n=7), C. ryanae (n=5), C. parvum (n=4), C. baileyi (n=1) and a genetically distinct and potentially novel species in two isolates from horses. Sub-genotype analysis of the 4 C. parvum isolates at the 60-kDa glycoprotein (gp60) locus identified subtype IIaA19G2R1 (n=2) and IIaA16GR1 (n=2). For the human samples, 4 positives (8.3% prevalence) were detected. Of these, two were C. parvum (subtypes IIdA20G1 and IIaA15G2R1) and two were C. hominis (subtypes 1bA9G3 and 1bA10G2R2). Further studies are required to better understand the epidemiology and transmission of Cryptosporidium in Jordan.

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Section: Discussionmentioning

confidence: 99%

Genetic characterization of Cryptosporidium in animal and human isolates from Jordan

Hijjawi

Mukbel

Yang

et al. 2016

Veterinary Parasitology

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“…In other regions of China, prevalence of Cryptosporidium in children in available reports ranged from 0.7-5.06% [23] and 1.3-9.9% [24] in Jiangsu Province; 1.3% [27] and 2.14-5.19% [29] in Anhui Province; 4.05-7.14% in Changsha [26] and 5.29% in Yunnan Province [28]. In other tropical developing countries, Cryptosporidium prevalence has been reported ranges from 1.1% to 18.7% [34] in Brazil and 29.6% in the State of Puebla of Mexico [38].…”

Section: Discussionmentioning

confidence: 99%

“…Cryptosporidium infection in children has been sporadically reported in different regions of China including Jiangsu Province [23,24], Shanghai [25], Changsha [26], Anhui province [27], Yunnan Province [28], and Anhui province [29]. Guangzhou, located just the south of the Tropic of Cancer, is the capital and largest city of Guangdong province in South China.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Cryptosporidium Infection in Children Hospitalized for Diarrhea in Guangzhou, China

Chen¹,

Atwill²,

Zhong³

et al. 2017

J Bacteriol Parasitol

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This study was conducted to determine the prevalence, species and risk factors of Cryptosporidium infection in children hospitalized for diarrhea in Guangzhou region of China. A cross-sectional study was conducted to assess the prevalence and risk factors of Cryptosporidium infection in children (2 weeks to 10 years old) who were hospitalized for diarrhea. Cryptosporidium oocysts were detected using direct immunfluorescent assay and species were determined by sequencing a fragment (~800 bp) of the 18S rRNA gene. A questionnaire contains host, sociodemographic, family, hygiene, diet, zoonotic, and environmental risk factors was administered to patients to identify key factors associated with infections. The observed Cryptosporidium prevalence was 6.9% and the true prevalence was estimated to be 9.0%. Cryptosporidium infection was similar between male (7.4%) and female (6.1%) children and negatively associated with age (i.e., infection was more likely in younger children). Infections in children were significantly associated with family members' diarrhea within past one month. Infection in children in suburban hospitals (7.8%) was significantly higher than that in urban hospitals (2.1%). The overall prevalence of Cryptosporidium in rainy season was significantly higher than that in non-rainy seasons. DNA sequences of the 18S rRNA gene from infected children were 99.12% to 100% identical to sequences in the GenBank of C. parvum isolates from humans and animals. Future works should determine the sources of zoonotic Cryptosporidium and routes of waterborne exposure in the rainy season in this region.

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“…Fayer et al., 2010, Elwin et al., 2012) C. xiaoi Fayer et al., 2010 Ovis aries (Sheep)Sheep and goatsAdamu et al., 2014 C. ryanae Fayer et al., 2008 Bos taurus (Cattle)CattleNone reported C. macropodum Power and Ryan, 2008 Macropus giganteus (Kangaroo)MarsupialsNone reported C. fragile Jirků et al., 2008 Duttaphrynus melanostictus (Toad)ToadsNone reported C. fayeri Ryan et al., 2008 Macropus rufus (Kangaroo)MarsupialsWaldron et al., 2010 C. bovis Fayer et al., 2005 Bos taurus (Cattle)CattleKhan et al., 2010, Ng et al., 2012, Helmy et al., 2013 C. suis Ryan et al., 2004 Sus scrofa (Pig)PigsXiao et al., 2002a, Leoni et al., 2006, Cama et al., 2007, Wang et al., 2013a C. galli Pavlásek, 1999, Ryan et al., 2003 Spermestidae, Frangillidae, Gallus gallus, Tetrao urogallus, Pinicola enucleator (Birds)BirdsNone reported C. hominis Morgan Ryan et al., 2002 Homo sapiens (Human)HumansMost common species in humans C. molnari Alvarez-Pellitero and Sitjà-Bobadilla, 2002 Sparus aurata (Gilt-head sea bream) and Dicentrarchus labrax (European seabass)FishNone reported C. canis Fayer et al., 2001 Canis familiaris (Dog)DogsMany reports (cf. Lucio-Forster et al., 2010) C. andersoni Lindsay et al., 2000 Bos taurus (Cattle)CattleLeoni et al., 2006, Morse et al., 2007, Waldron et al., 2011, Agholi et al., 2013, Jiang et al., 2014, Liu et al., 2014…”

Section: Introductionmentioning

confidence: 99%

Public health significance of zoonotic Cryptosporidium species in wildlife: Critical insights into better drinking water management

Zahedi

Paparini

Jian

et al. 2016

International Journal for Parasitology: Parasites and Wildlife

149

144

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Cryptosporidium is an enteric parasite that is transmitted via the faecal–oral route, water and food. Humans, wildlife and domestic livestock all potentially contribute Cryptosporidium to surface waters. Human encroachment into natural ecosystems has led to an increase in interactions between humans, domestic animals and wildlife populations. Increasing numbers of zoonotic diseases and spill over/back of zoonotic pathogens is a consequence of this anthropogenic disturbance. Drinking water catchments and water reservoir areas have been at the front line of this conflict as they can be easily contaminated by zoonotic waterborne pathogens. Therefore, the epidemiology of zoonotic species of Cryptosporidium in free-ranging and captive wildlife is of increasing importance. This review focuses on zoonotic Cryptosporidium species reported in global wildlife populations to date, and highlights their significance for public health and the water industry.

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Cryptosporidium andersoni as a novel predominant Cryptosporidium species in outpatients with diarrhea in Jiangsu Province, China

Cited by 61 publications

References 40 publications

Genetic characterization of Cryptosporidium in animal and human isolates from Jordan

Genetic characterization of Cryptosporidium in animal and human isolates from Jordan

Prevalence and Risk Factors of Cryptosporidium Infection in Children Hospitalized for Diarrhea in Guangzhou, China

Public health significance of zoonotic Cryptosporidium species in wildlife: Critical insights into better drinking water management

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