Cryptosporidiosis in Patients with Colorectal Cancer

Sulżyc-Bielicka, Violetta; Kuźna-Grygiel, Wanda; Kołodziejczyk, Lidia; Bielicki, Dariusz; Kładny, Józef; Stępień-Korzonek, M.; B, Telatyńska-Smieszek

doi:10.1645/ge-1025r1.1

Cited by 44 publications

(44 citation statements)

References 17 publications

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“…An epidemiologic study in Poland reported a frequency of 18% of cryptosporidiosis in patients with colorectal cancer (17). However, in this report it was unclear whether C. parvum behaved as a carcinogenesis factor or simply as an opportunistic agent whose development was enhanced by host immunosuppression.…”

mentioning

confidence: 78%

Fulminant Cryptosporidiosis after Near-Drowning: a Human Cryptosporidium parvum Strain Implicated in Invasive Gastrointestinal Adenocarcinoma and Cholangiocarcinoma in an Experimental Model

Certad

Benamrouz

Guyot

et al. 2012

Appl Environ Microbiol

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hIn the present work, we report the characterization of a Cryptosporidium parvum strain isolated from a patient who nearly drowned in the Deule River (Lille, France) after being discharged from the hospital where he had undergone allogeneic stem cell transplantation. After being rescued and readmitted to the hospital, he developed fulminant cryptosporidiosis. The strain isolated from the patient's stools was identified as C. parvum II2A15G2R1 (subtype linked to zoonotic exposure) and inoculated into SCID mice. In this host, this virulent C. parvum isolate induced not only severe infection but also invasive gastrointestinal and biliary adenocarcinoma. The observation of adenocarcinomas that progressed through all layers of the digestive tract to the subserosa and spread via blood vessels confirmed the invasive nature of the neoplastic process. These results indicate for the first time that a human-derived C. parvum isolate is able to induce digestive cancer. This study is of special interest considering the exposure of a large number of humans and animals to this waterborne protozoan, which is highly tumorigenic when inoculated in a rodent model.

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mentioning

confidence: 78%

Fulminant Cryptosporidiosis after Near-Drowning: a Human Cryptosporidium parvum Strain Implicated in Invasive Gastrointestinal Adenocarcinoma and Cholangiocarcinoma in an Experimental Model

Certad

Benamrouz

Guyot

et al. 2012

Appl Environ Microbiol

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“…In addition, the high prevalence of Cryptosporidium infection in our patients suggests that these protozoaare widespread in our environment. This high prevalence of infections with these opportunistic parasites among patients with cancer may result from the patients' reduced immunity [30].…”

Section: Discussionmentioning

confidence: 99%

Cryptosporidiosis in patients with diarrhea and chronic liver diseases

Mousa

Abdel‐Razik

El-Nahas

et al. 2014

J Infect Dev Ctries

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Introduction: The aim of this study was to evaluate the epidemiology and clinical significance of Cryptosporidium in patients with diarrhea and chronic liver diseases. Methodology: The study included 150 patients with chronic liver diseases and diarrhea, and 50 subjects with diarrhea as a control group. Stool samples were screened for the presence of Cryptosporidium by microscopic examination after modified Ziehl-Neelsen staining and detection of Cryptosporidium coproantigen by enzyme-linked immunosorbent assay (ELISA). Results: The prevalence of Cryptosporidium infection in patients with chronic liver diseases was 30% (45/150) versus 14% (7/50) in controls. Cryptosporidium infection increased with the progression of chronic liver diseases from Child-Pugh class A to Child-Pugh class C (p< 0.001) and from model for end-stage liver disease (MELD) score ≤ 9 to MELD score > 9 (p< 0.031). Nine patients in Child-Pugh class C with diarrhea associated with Cryptosporidium infection developed hepatic encephalopathy, and only diarrhea was identified as a precipitating factor for hepatic encephalopathy. Conclusions: Cryptosporidium is one of the important causes of diarrhea in patients with chronic liver diseases. The infection significantly increased with the progression of chronic liver diseases. In patients with advanced chronic liver diseases, Cryptosporidium infection may be a precipitating factor of hepatic encephalopathy.

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“…Chronic intestinal Cryptosporidium parvum infection is not rare in people with advanced HIV infection, and the organism has been observed in malignant colon tissue. 19,[21][22][23][24][25][26][27] Using a mouse model, Sasahara et al demonstrated the loss of absorptive cells and goblet cells, and the apoptosis of intestinal epithelial cells following Cryptosporidium parvum infection. 28 This protozoan is usually an intracellular parasite of the small intestine epithelium.…”

Section: Discussionmentioning

confidence: 99%

Opportunistic Intestinal Infections and Risk of Colorectal Cancer Among People with AIDS

Shebl

Engels

Goedert

2012

AIDS Research and Human Retroviruses

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Because mucosal inflammation contributes to colorectal carcinogenesis, we studied the impact of intestinal infections on risk of this malignancy among people with AIDS (PWA). Using the population-based HIV/AIDS Cancer Match, which includes approximately half of all PWA in the United States, the cancer registries ascertained colorectal cancers (ICD-O3 codes C180-C189, C199, C209, and C260). During 4-120 months after AIDS onset, risk of cancer occurring after AIDS-defining intestinal infections (considered as time-dependent exposures) was estimated with hazard ratios (HR) and 95% confidence intervals (CI) calculated by Cox regression. Analyses included cancers overall and by histology and anatomic site. After excluding 118 squamous cell rectal cancers (possible anal cancers), we analyzed 320 incident colorectal cancer cases that occurred among 471,909 PWA. Colorectal cancer risk was marginally elevated following cryptosporidiosis (HR = 2.08, 95% CI = 0.93-4.70, p = 0.08) and mucocutaneous herpes (HR = 1.69, 95% CI = 0.97-2.95, p = 0.07) but not with Pneumocystis pneumonia (HR = 0.79, 95% CI = 0.57-1.10). Cryptosporidiosis was associated with rare colon squamous cell carcinoma [N = 8, HR = 13, 95% CI = 1.5-110] and uncommon histologies [HR = 4.4, 95% CI = 1.1-18, p = 0.04], but it was not associated with colorectal adenocarcinoma (N = 269, HR = 1.3, 95% CI = 0.4-3.9, p = 0.70). Mucocutaneous herpes was associated with colon squamous cell carcinoma (HR = 13, 95% CI = 2.4-67, p = 0.003) but not with colorectal adenocarcinoma (HR = 1.3, 95% CI = 0.6-2.6, p = 0.52) or uncommon histologies (HR = 2.5, 95% CI = 0.8-8.2, p = 0.13). Colon squamous cell carcinoma risk was significantly elevated among PWA who had cryptosporidiosis or mucocutaneous herpes. These findings might suggest that HPV or inflammation from other infection may contribute to carcinogenesis.

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Cryptosporidiosis in Patients with Colorectal Cancer

Cited by 44 publications

References 17 publications

Fulminant Cryptosporidiosis after Near-Drowning: a Human Cryptosporidium parvum Strain Implicated in Invasive Gastrointestinal Adenocarcinoma and Cholangiocarcinoma in an Experimental Model

Fulminant Cryptosporidiosis after Near-Drowning: a Human Cryptosporidium parvum Strain Implicated in Invasive Gastrointestinal Adenocarcinoma and Cholangiocarcinoma in an Experimental Model

Cryptosporidiosis in patients with diarrhea and chronic liver diseases

Opportunistic Intestinal Infections and Risk of Colorectal Cancer Among People with AIDS

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