Cryptorchidism in Mice with an Androgen Receptor Ablation in Gubernaculum Testis

Kaftanovskaya, Elena M.; Huang, Zaohua; Barbara, Agustin M.; Gendt, Karel De; Verhoeven, Guido; Gorlov, Ivan P.; Agoulnik, Alexander I.

doi:10.1210/me.2011-1283

Cited by 64 publications

(94 citation statements)

References 32 publications

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“…Testicular descent GU-ARKO Rarb-Cre Gubernacular ligament Cryptorchidism, smaller testes and epididymides, early subfertility, and late infertility [88]. SM-ARKO SM22a-Cre Smooth muscle cells No effect on testicular descent [88].…”

Section: Ptm-arko Smmhc-crementioning

confidence: 99%

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Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells1

Chang¹,

Lee²,

Wang³

et al. 2013

Biology of Reproduction

124

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Androgens/androgen receptor (AR) signaling is involved primarily in the development of male-specific phenotypes during embryogenesis, spermatogenesis, sexual behavior, and fertility during adult life. However, this signaling has also been shown to play an important role in development of female reproductive organs and their functions, such as ovarian folliculogenesis, embryonic implantation, and uterine and breast development. The establishment of the testicular feminization (Tfm) mouse model exploiting the X-linked Tfm mutation in mice has been a good in vivo tool for studying the human complete androgen insensitivity syndrome, but this mouse may not be the perfect in vivo model. Mouse models with various cell-specific AR knockout (ARKO) might allow us to study AR roles in individual types of cells in these male and female reproductive systems, although discrepancies are found in results between labs, probably due to using various Cre mice and/or knocking out AR in different AR domains. Nevertheless, no doubt exists that the continuous development of these ARKO mouse models and careful studies will provide information useful for understanding AR roles in reproductive systems of humans and may help us to develop more effective and more specific therapeutic approaches for reproductive system-related diseases.

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Section: Ptm-arko Smmhc-crementioning

confidence: 99%

“…SM-ARKO SM22a-Cre Smooth muscle cells No effect on testicular descent [88]. M-ARKO ACTA1-Cre Skeletal muscles No effect on testicular descent [88].…”

Section: Ptm-arko Smmhc-crementioning

confidence: 99%

Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells1

Chang¹,

Lee²,

Wang³

et al. 2013

Biology of Reproduction

124

View full text Add to dashboard Cite

show abstract

“…Jensen MS et al concluded that smoking more than 10 cigarettes a day during pregnancy increased the risk of cryptorchidism. Jensen MS et al [2] & Kaftanovskaya EM et al [3] concluded that the second inguino-scrotal stage of testicular descent is clearly androgen-dependent [3]. The diagnosis of cryptorchidism is made by physical examination.…”

Section: Discussionmentioning

confidence: 99%

A Rare Variant of Inguinal Hernia: Cryptorchid Testis at the Age of 60: An Unusual Case Report

Pathak¹,

Ajit²,

Parikh³

et al. 2017

MOJCR

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Cryptorchidism is characterized by the extra-scrotal position of the testis. Although inguinal hernia is frequent, cryptorchid testis at the age of 60 years is an uncommon entity. We wish to present this extremely rare case of inguinal hernia, which is the first one that we have encountered in our practice, along with the accompanying prognosis and therapeutic issues and a review of the literature.Keywords: Cryptorchidism; Extra-scrotal position; Inguinal hernias extremely rare case of inguinal hernia, which is the first one that we have encountered in our practice, along with the accompanying prognosis and therapeutic issues and a review of the literature. Case ReportWe report the case of a 60 years old adult male patient who was admitted due to left inguinal hernia. His medical history was not found to be relevant. Patient was referred with an inguinal hernia with recurrent severe colicky pain on appearance of hernia. When the patient used to cough, the hernia used to appear. Physical examination revealed left inguinal hernia. The scrotum showed absence of left testis in the pre-operative period (Figure 1). The diagnosis was left inguinal hernia with absent left testis. The rest of the examination was unremarkable. He had no known history of testicular disease. The patient did not have a problem of infertility. Surgical exploration revealed the presence of cryptorchid testicle in inguinal hernia. The left testis with its overlying tunica vaginalis was found at the deep inguinal ring. A viable normal sized testis was found in the hernial sac with its blood vessels and vas deferens. The testicle was viable. Left testicle was resected for the fear of malignancy. The hernia sac was, also, resected (Figure 2-5). Surgical correction was made and the hernia was repaired using a synthetic mesh (Lichtenstein Hernioplasty) (Figure 6,7). Histopathological examination confirmed a normal testis and the presence of leydig cells and the seminiferous tubule without testicular germ cell tumor (TGCT). The patient tolerated the procedure well and the post-operative period was uneventful.

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“…(Jensen et al, 2007) Kaftanovskaya EM et al concluded that the second inguino-scrotal stage of testicular descent is clearly androgen-dependent. (Kaftanovskaya et al, 2012) The diagnosis of cryptorchidism is made by physical examination. The diagnosis of cryptorchidism should be considered when non-palpable testis and inguinal hernia are present, although, each patient might experience the symptoms differently.…”

Section: Discussionmentioning

confidence: 99%

A Rare Variant of Inguinal Hernia: Cryptorchid Testis at the Age of 60: An Unusual Case Report

Das¹,

Nayyar²

2017

ijccr

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Cryptorchidism in Mice with an Androgen Receptor Ablation in Gubernaculum Testis

Cited by 64 publications

References 32 publications

Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells1

Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells1

A Rare Variant of Inguinal Hernia: Cryptorchid Testis at the Age of 60: An Unusual Case Report

A Rare Variant of Inguinal Hernia: Cryptorchid Testis at the Age of 60: An Unusual Case Report

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