Cryptorchidism and Testicular Cancer

Abstract

An analysis of 125 patients with a history or clinical evidence of cryptorchidism and testicular germinal tumor treated at our hospital from 1934 to 1975 is presented. Cryptorchidism was corrected ipsilaterally or contralaterally in 83 patients with intrascrotal testis cancer when they were from 4 to 42 years old, either spontaneously (21 patients), by orchiopexy (51 patients) or by hormonal therapy (11 patients). Forty-two cryptorchid patients (uncorrected cases) presented with either ipsilateral inguinal (24 patients), abdominal (14 patients) or contralateral intrascrotal tumors (4 patients). Tumor histologic types on orchiectomy were pure seminoma in 54 patients, embryonal carcinoma in 35, teratocarcinoma in 33 and pure choriocarcinoma in 3. The 5-year survival rates were 60 per cent for the corrected cases and 63 per cent for the uncorrected cases according to cryptorchid state, and they were 78 per cent in patients with pure seminoma and 48 per cent in patients with other germinomas according to histologic type. The majority (58 of 73) of 5-year survivors received regional lymphatic irradiation, in 39 patients with pure seminoma, and/or systemic chemotherapy, in 19 patients with germinal carcinomas, with or without regional lymphadenectomy.

Inguinal Lymphnode Metastatic Testicular Seminoma: A Case Report and Review of Literature

“…In patients with a prior history of orchidopexy or scrotal surgery who have a testicular tumor, the incidence of inguinal metastases is unclear but has been reported in series varying from two percent [8] up to ten percent [9]. Daugaard et al evaluated the incidence of inguinal lymph node metastases in 695 patients with stage I testicular cancer [8].…”

Seminoma presented with acute abdomen due to ileum perforation

“…In undescended testicles the incidence of malignancy is considered to be 3 to 48 times greater than in the general population [15,16]. Approximately 10% of all the testicular tumors appear on an undescended testicle [15,16].…”

“…Approximately 10% of all the testicular tumors appear on an undescended testicle [15,16]. Undescended testis is a very frequent pathology that affects 2-5% of children.…”

“…Of the non-palpable testicles, it is absent in only 20% of the cases; the rest are in the abdomen or the inguinal canal. Abdominal testicles present a higher rate of malignancy than the ones located in the inguinal region [15]. The abdominal testicles develop cancer in 30% of cases [17].…”

“…The abdominal testicles develop cancer in 30% of cases [17]. The high temperatures in the inguinal canal and abdomen would be responsible for the organ malignant degeneration [15]. The location of the testis is also a factor in the development of malignancy; an intraabdominal testis is five times more likely to develop a malignancy than is an inguinal one [18].…”