Cryptorchidism and fertility

Hecker, Waldemar Ch.; Hienz, H. A.

doi:10.1016/s0022-3468(67)80005-8

Cited by 65 publications

(15 citation statements)

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“…Ratief [ 13] suggested complete infertility and sterility in these patients, especially when operated on at a late age. Hecker [ 10] reported the fertility rate to be 35% in 346 successfully operated cases with unilateral undescended testis. In contrast, Gilhooly et al .…”

Section: Discussionmentioning

confidence: 99%

Fertility and histological studies of the contralateral testes in two different intra‐ and extra‐abdominal rat models of unilateral cryptorchidism

Zakaria

Shono

Imajima

et al. 1998

British Journal of Urology

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Objective To investigate the effect of location of the testis on both testicular development and fertility in unilateral cryptorchidism. Material and methods Forty‐nine Wistar King A newborn male rats were divided into three groups. In group 1 (15 rats) intra‐abdominal unilateral cryptorchidism were created by the intra‐abdominal fixation of the testis in the neonatal period. In group 2 (16 rats) extra‐abdominal unilateral cryptorchidism was created by extra‐abdominal fixation of the gubernaculum in the neonatal period. In group 3, 18 rats underwent a sham operation as controls. At 90 days of age, fertility was then assessed in each rat by housing it with two mature virgin females for 2 weeks. Thereafter, at 115–120 days of age, the rats were killed and their testes removed for histological examination. Results There was no significant difference in the pregnancy rate between females coupled with rats from any group, but the mean number of offspring was significantly lower in females coupled with rats in group 1 than in group 2. Furthermore, histological examination of both the cryptorchid and contralateral scrotal testes showed more severe changes in the intra‐abdominal than the extra‐abdominal testes. Conclusion These results suggest that intra‐abdominal cryptorchid testes are significantly more impaired than extra‐abdominal cryptorchid testes, and that such impairment might be caused by exposure of the testis to a higher temperature. The more severely impaired undescended testes may thus induce the degeneration of the contralateral scrotal testis and thereby cause subfertility in the intra‐abdominal unilateral cryptorchid rat model.

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Section: Discussionmentioning

confidence: 99%

Fertility and histological studies of the contralateral testes in two different intra‐ and extra‐abdominal rat models of unilateral cryptorchidism

Zakaria

Shono

Imajima

et al. 1998

British Journal of Urology

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“…Is it fair to ask if some, or perhaps many of the fertile men after bilateral orchiopexy had originally had retractile or high scrotal testes? The case is strong for saying that in cryptorchidism both the undescended and the so-called normal contralateral testis are intrinsically abnormal (Hecker and Hienz, 1967). This aspect is well reviewed by Sheldon (1985).…”

Section: Effect On Infertilitymentioning

confidence: 99%

Undescended Testis—the Need for a Standard Classification

Whitaker

1993

British Journal of Urology

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“…Untreated unilateral undescent is often accompanied by impaired fertility,8 and the scrotal testis in these cases is apt to be histologically abnormal. 6 However, if the undescended testis is brought down before puberty, fertility may be improved.8 Though hormone therapy is probably less popular than it was, a recent study9 from which rectractile testes were carefully excluded has shown it to be effective in 330, of bilateral and 1600 of unilateral cases, with a total dose of 10,000 i.u. of chorionic gonadotropin.…”

Section: Undescended Testismentioning

confidence: 99%

Undescended Testis

1970

BMJ

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Cryptorchidism and fertility

Cited by 65 publications

References 1 publication

Fertility and histological studies of the contralateral testes in two different intra‐ and extra‐abdominal rat models of unilateral cryptorchidism

Fertility and histological studies of the contralateral testes in two different intra‐ and extra‐abdominal rat models of unilateral cryptorchidism

Undescended Testis—the Need for a Standard Classification

Undescended Testis

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