Cryptolepine Analog Exhibits Antitumor Activity against Ehrlich Ascites Carcinoma
Cells in Mice via Targeting Cell Growth, Oxidative Stress, and PTEN/Akt/mTOR
Signaling Pathway
Bishoy El-Aarag,
Eman S. Shalaan,
Abdullah A.S. Ahmed
et al.
Abstract:Background:
The efficacy of chemotherapy continues to be limited due to associated toxicity and
chemoresistance. Thus, synthesizing and investigating novel agents for cancer treatment that could potentially
eliminate such limitations is imperative.
Objective:
The current study aims to explore the anticancer potency of cryptolepine (CPE) analog on Ehrlich
ascites carcinoma cells (EACs) in mice.
Methods:
The effect of a CPE analog on EAC cell viability and ascites volume, as well as malonaldehyde, total
anti… Show more
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