Cryptogenic pyogenic liver abscess as a sign of colorectal cancer: a population-based 5-year follow-up study

Abstract

We conclude that cryptogenic PLA is an alarm that may signal colorectal cancer, especially among female patients with diabetes.

Genotoxic Klebsiella pneumoniae in Taiwan

“…In a colitis-associated CRC mouse model, the proliferation of a genotoxic E. coli commensal strain, NC101, was demonstrated to be favored by an inflammatory milieu and thus promoted tumorigenesis of CRC [26]. Several clinical studies have demonstrated the relationship between CRC, PLA and K. pneumoniae in Taiwan [17], [18], [20]. The hazard ratio of CRC was 3.36 times greater for patients with PLA as reported in a nationwide population-based 5-year follow-up study comprised of 274 PLA patients and 1,370 randomly selected subjects [18].…”

A solid organising cryptogenic liver abscess and its association with a colonic tubullovillous adenoma

“…On the contrary, patients with suspected CLA have shown to have higher risks of developing colorectal cancer on long-term follow-up. In a study by Lai et al 7 on patients with CLA; there is a 3.36 times greater risk of developing colorectal cancer in a 5 year follow-up, as compared with those who did not have CLA. A similar study by Mohsen et al 4 also showed the same increased risk of colorectal cancer in CLA.…”

“…These findings strongly suggest the role of colonic abnormalities as a probable cause of CLA. Several studies have now shown colonoscopy as a vital tool in both the diagnosis, as well as cancer surveillance in patients with CLA 4 5 7…”

“…Cryptogenic liver abscess (CLA) has been well recognised as the possible initial manifestation of a silent colorectal carcinoma 6 7. However, its association with tubullovillous adenomas has rarely been reported, with only one case published in the English literature 6.…”

Clinical Outcomes and Prognostic Factors of Cancer Patients with Pyogenic Liver Abscess

“…Awareness of the clinical presentation and prognostic factors of high-risk patient groups is very important. Some studies have attempted to explore the clinical course and prognostic factors of PLA patients with underlying malignancy 12,16,18 ; however, an appropriate assessment of the risk factors for mortality regarding abscess characteristics and/or microbiological information was lacking in the previous reports. To identify prognostic factors for PLA patients with underlying malignancy, we conducted a retrospective study to collect detailed clinical information of these patients, including clinical manifestations, imaging and laboratory findings, microbiologic studies, treatment, and outcomes.…”