Cryptogenic Multifocal Ulcerous Stenosing Enteritis: A Review of the Literature

Abstract

Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is an extremely rare illness characterised by chronic or relapsing subileus status resulting from multiple small intestinal fibrous strictures and multiple shallow ulcers of the small bowel. The etiology is unknown and pathogenesis is not fully understood. Therapy with systemic glucocorticosteroids is the treatment of choice. However, most patients develop corticosteroid dependence. Deep enteroscopy enables precise diagnostic work, possible endoscopic treatment of stenoses; may obviate the need for surgery and prevent excessive small bowel resections.

Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine

“…), which are rarely seen in patients with CNSU [6,7,10,11]. Finally, steroid therapy has a beneficial effect in CMUSE [8,9]. Considering these differences in clinical condition, CMUSE should be assumed to be different from CNSU.…”

“…In Western countries, although the clinicopathologic features seem to be different from those of CNSU, Perlemuter et al [8] have reported a similar enteropathy, termed ''cryptogenic multifocal ulcerous stenosing enteritis (CMUSE)''. In addition, a recent review considered CNSU to be identical to CMUSE [9]. Thus, precise recognition of the clinical entity of CNSU is mandatory to avoid misinterpretation.…”

Cryptogenic Multifocal Ulcerous Stenosing Enteritis (CMUSE): A Tale of Three Decades

“…The treatment of CMUSE remains symptomatic. Enteral and parenteral nutrition along with iron supplementation have been tried before and are transiently effective 9. Our patient responded to nonresidual diet and medium chain triglycerides.…”

A rare cause of multiple small bowel ulcers and strictures in a 10-year-old child

“…Cryptogenic multifocal ulcerous stenosing enteritis is a rare idiopathic cause of ulceration and stricture of small bowel, which can be presented with acute or chronic GI bleeding, symptoms of bowel obstruction, abdominal pain, anemia, hypoalbuminemia, and perforation (1)(2)(3)(4)(5).…”

“…Differential diagnosis of other less common conditions should be considered after certain diseases have been ruled out (e.g., IBD, infection, cancer). Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is a rare condition that has been reported in both adults and children (1). A proposed diagnosis of CMUSE can be made after excluding other diseases.…”