Cryptogenic Fibrosing Pleuritis with Rapidly Progressive Restrictive Ventilatory Dysfunction

Abstract

Cryptogenic bilateral fibrosing pleuritis is a rare condition, and its pathogenesis and clinical course are poorly understood, with no established therapy available. A 61-year-old man presented with bilateral pleural thickening and lymphocytic exudative effusions. The patient was diagnosed with fibrosing pleuritis with no evidence of a known etiology on a surgical pleural biopsy. Within 16 months from the onset of respiratory symptoms, restrictive ventilatory impairment progressed rapidly, resulting in hypercapnic respiratory failure requiring home oxygen and non-invasive positive pressure ventilation therapies.

Research progress on gel-based nanocomposites for diagnosis and treatment of respiratory diseases

“…In stage III (dorsal or thoracic) of ankylosing spondylitis (AS), patients may experience chest and thoracoiabdominal pain, along with limited thorax expansion due to inflammation-related damage to the costovertebral and sternocostal joints pleural effusion, 21,22 whether caused by tuberculosis, tumors, connective tissue diseases, or other pleural diseases such as pleural mesothelioma, can also restrict the expansion of thoracic or lung tissue and reduce the compliance of thoracic and/or lung. 23…”

“…In stage III (dorsal or thoracic) of ankylosing spondylitis (AS), patients may experience chest and thoracoiabdominal pain, along with limited thorax expansion due to inflammation-related damage to the costovertebral and sternocostal joints pleural effusion, 21,22 whether caused by tuberculosis, tumors, connective tissue diseases, or other pleural diseases such as pleural mesothelioma, can also restrict the expansion of thoracic or lung tissue and reduce the compliance of thoracic and/or lung. 23 Furthermore, obesity can contribute to significant restrictive lung physiology and give rise to obesity hypoventilation syndrome (OHS). 24 Individuals with severe obesity may experience severe and potentially life-threatening respiratory complications.…”