“…The common initial sites of Cryptococcal infection include the lung and the brain, which primarily suggests pathogenesis through the respiratory tract. However, various infection sites reported on the skin, lung, parotid, muscle, breast, or mediastinal abscess in the literature favors the hypothesis of hematogenous or lymphatic dissemination [ 5 , 11 , 12 ]. In the present reported patient, the culture of blood, CSF, and breast aspiration were positive, which proved hematogenous spreading and might explain why the breast infection was bilateral, and diffuse.…”