Cryptococcosis of the spleen: Diagnosis by fine-needle aspiration cytology

Mandreker, Suresh; Pinto, R.; Rebello, Marissa; Nadkarni, Nisha

doi:10.1002/(sici)1097-0339(199806)18:6<471::aid-dc18>3.0.co;2-e

Cited by 5 publications

(2 citation statements)

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“…In our study, the overall FNAB and FS sensitivities were 39.7% and 42%, respectively. Both method sensitivities in our series were lower than in previous studies that reported FNAB sensitivity from 53% to 98% and FS sensitivity from 50% to 83.3% [23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44]. Those differences in the FS and FNAB sensitivities from center to center can mostly be attributed to variations in methodology [16],.…”

Section: Discussioncontrasting

confidence: 87%

Role of Fine‐needle Aspiration Biopsy and Frozen Section in the Management of Papillary Thyroid Carcinoma Subtypes

2004

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Since fine-needle aspiration biopsy (FNAB) was introduced, the value of frozen section (FS) has been questioned. This study compares FNAB and FS sensitivities among the usual form of papillary thyroid cancer (uPTC) and variants of PTC such as tall cell (tcPTC), follicular (fPTC), and Hurthle cell (HcPTC). A total of 257 patients who underwent preoperative FNAB, intraoperative FS, and thyroidectomy for PTC were, randomly selected from a database of a university teaching hospital in Toronto. There were 218 females (84.8%) and 39 males (15.2%), from 19 to 89 years of age (mean of 44 years), having uPTC (n = 212), fPTC (n = 24), HcPTC (n = 14), and tcPTC (n = 7). Data were analyzed using chi2 test. Sensitivities were calculated by division of true positives and by the sum of true positives and false negatives. True positives had to reflect a conclusive diagnosis of cancer. The FNAB sensitivities were uPTC (39.2%), fPTC (25%), HcPTC (42.9%), tcPTC (85.7%), similar to FS sensitivities (p = 0.497) for uPTC (44.3%), fPTC (16.7%), HcPTC (42.9%), and tcPTC (71.4%). Use of FS following FNAB increased sensitivities for uPTC to 56.1%, fPTC to 29.2%, and tcPTC to 100%. In addition, FS did not increase FNAB sensitivity in HcPTC. Combination FNAB plus FS failed in 43.9% of uPTC, 70.8% of fPTC, and 57.1% of HcPTC. We concluded that FNAB and FS sensitivity vary with PTC subtype and are still necessary for selection and treatment. The recognition of morphologic subtypes of PTC from the FNAB could optimize the selection of patients for intraoperative FS, enhance the preoperative assessment of prognosis, facilitate the surgical planning, and simplify the preparation of postoperative adjuvant therapy.

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Section: Discussioncontrasting

confidence: 87%

Role of Fine‐needle Aspiration Biopsy and Frozen Section in the Management of Papillary Thyroid Carcinoma Subtypes

2004

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“…In 1970, Söderström2 used the technique extensively to diagnose splenomegaly. Because of the general skepticism toward the cytologic diagnosis of lymphoproliferative disorders and the fear of hemorrhage or rupture, the application has not been reported much3–21 and has not become as widely used as in other organs. In addition, the tremendous progress of noninvasive diagnostic tools and imaging techniques has reduced the need of direct investigation of this organ through biopsies or splenectomy.…”

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confidence: 99%

Fine-needle aspiration biopsy and flow cytometry immunophenotyping of lymphoid and myeloproliferative disorders of the spleen

Zeppa

Picardi

Marino

et al. 2002

Cancer

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BACKGROUND Flow cytometry (FC) is a useful adjunct to fine‐needle aspiration biopsy (FNAB) in the evaluation of lymphoproliferative disorders. The application of FC to FNAB of the spleen (sFNAB) is reported. METHODS Flow cytometry was performed on 18 sFNAB collected over 3 years. The series comprised 10 cases of non‐ Hodgkin lymphomas (NHL), 2 cases insufficient for diagnosis, 2 cases of reactive hyperplasia (RH), and 4 cases of myeloid metaplasia (MM). FNAB was performed under ultrasound guidance using a 22‐gauge needle. One or two passes were sufficient to prepare a conventional smear that was immediately evaluated to select the cases studied and to prepare a cell suspension for FC. The following fluoresceinated antibodies were used: CD3, CD19/κ/λ, FMC7/CD23/CD19, Bcl‐2, and CD13/HLA‐DR. In six cases, cytospins were also prepared for immunocytochemistry and were tested for CD20 (L26), CD45Ro, and κ and λ light chain expression. RESULTS Flow cytometry contributed to the diagnosis of all cases of NHL by assessing light chain restriction. The specific subtype was also diagnosed by CD19/CD5 and CD 19/CD10 coexpression in two cases. Flow cytometry quantified the percentage of myeloid cells in MM cases and contributed to the cytologic diagnosis showing a polyclonal light chain expression in RH cases.. Immunocytochemistry was effective and concordant in four cases. Patients tolerated the sFNAB well and no complications were reported. Cytologic and FC diagnoses were confirmed by follow‐up and by histologic evaluation in cases in which splenectomy was performed for therapeutic purposes. CONCLUSION Flow cytometry applied to sFNAB corroborates the cytologic diagnosis in lymphoid and myeloproliferative disorders of the spleen and allows therapeutic decisions avoiding splenectomy. Cancer (Cancer Cytopathol) 2003;99:118–27. © 2003 American Cancer Society.

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Funktionelle Anatomie, allgemeine Pathologie und Mitbeteiligung der Milz bei Erkrankungen anderer Organe

Diébold¹,

Rüdiger

Marx

et al. 2018

Pathologie

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Cryptococcosis of the spleen: Diagnosis by fine-needle aspiration cytology

Cited by 5 publications

References 5 publications

Role of Fine‐needle Aspiration Biopsy and Frozen Section in the Management of Papillary Thyroid Carcinoma Subtypes

Role of Fine‐needle Aspiration Biopsy and Frozen Section in the Management of Papillary Thyroid Carcinoma Subtypes

Fine-needle aspiration biopsy and flow cytometry immunophenotyping of lymphoid and myeloproliferative disorders of the spleen

Funktionelle Anatomie, allgemeine Pathologie und Mitbeteiligung der Milz bei Erkrankungen anderer Organe

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