Cryptococcosis of the larynx

Primary laryngeal cryptococcosis resembling laryngeal carcinoma

“…Although corticosteroid is commonly used for steroiddependent COPD patients and brings great benefit to COPD patients, it also exposes those patients to a significant risk of developing cryptococcosis. Isaacson et al have reported that the use of high-dose inhaled corticosteroid also increases patients' risk of developing cryptococcosis [2]. This elderly case of primary laryngeal cryptococcosis had undergone lengthy systemic corticosteroid therapy.…”

“…neoformans is a well-documented pathogenic fungus and is rarely implicated in primary laryngitis. To date, there are some reports of primary laryngeal cryptococcosis in English literature from European countries and the United States (Table 1) [1,2,[4][5][6][7][8][9][10]. However, the fungus is very neurotropic and readily frequent among immunocompromised host [11].…”

“…In contrast, the primary cryptococcal infection of the larynx is very rare [2][3][4][5][6][7]. In this report, we describe a case of primary laryngeal cryptococcosis in an 82-year-old female with a history of lengthy corticosteroid against COPD and rheumatoid arthritis.…”

“…It is estimated that cryptococcal infections develop in 6-8% of patients with AIDS in the U.S. [1]. Patients undergoing lengthy corticosteroid therapy are exposed to one of the significant risks for developing cryptococcal infections [2].…”

Cryptococcal Laryngitis: Case Report and Review of the Literature

“…Pseudoepitheliomatous hyperplasia was the most common histopathologic abnormality and was seen in 3 cases. ?, 8,10 In general, antifungal therapy is recommended for most patients with cryptococcal infections, especially those patients who are immunocompromised." Of the 6 patients included in this report, resolution of cryptococcallaryngitis was achieved in 4 patients treated with antifungal therapy, including our patient (Table 2 7 -11 ) .…”