Cryptococcal meningitis complicating sarcoidosis

Abstract

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Cryptococcal Meningitis in a HIV-Negative Patient

“…In the present case, the therapy was initiated before obtaining the result of the cultural examination, which was probably a decisive factor concerning its prognosis. As evidenced in several cases, the early initiation of treatment has prognostic implications [1] . It should be noted that when the diagnosis of pulmonary cryptococcosis was made, dissemination to the CNS should had been excluded due to the need for more aggressive treatment.…”

“…In a review of the literature conducted in 2016 by Leonhard et al, they found that the mean age of patients with sarcoidosis who developed cryptococcal meningitis was 39 years old and that 40% of patients were undergoing immunomodulatory therapy [1] . Our patient was well above this age group and has never been treated with systemic corticosteroid or other immunomodulators, which makes this case of particular interest.…”

“…In the case of sarcoidosis, it is a rare complication that must be considered, and which is explained by T-cell dysfunction. T-cell immunity is the main route of protection against cryptococcal infections [1,2] .…”

Fatal fulminant cryptococcemia complicating sarcoidosis: Is it to be expected?

“…Cryptococcosis, an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans , is a rare but severe complication of sarcoidosis [1]. In a series of 40 sarcoidosis patients with cryptococcal meningitis — the most frequent manifestation of cryptococcosis — identified recently in the literature, 43% (17/40) had a delayed diagnosis, mainly because of initial suspicion of neurosarcoidosis [1].…”

“…In a series of 40 sarcoidosis patients with cryptococcal meningitis — the most frequent manifestation of cryptococcosis — identified recently in the literature, 43% (17/40) had a delayed diagnosis, mainly because of initial suspicion of neurosarcoidosis [1].…”