CRYPTOCHROME mediates behavioral executive choice in response to UV light

Baik, Lisa S.; Fogle, Keri J.; Roberts, Logan; Galschiodt, Alexis M.; Chevez, Joshua A.; Recinos, Yocelyn; Nguy, Vinh; Holmes, Todd C.

doi:10.1073/pnas.1607989114

Cited by 48 publications

(94 citation statements)

References 53 publications

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“…It is not known currently what factors contribute to differential phase timing of circadian protein cycling among different tissue and cellular types. Our detailed characterization of light-evoked attraction/avoidance behavior in mosquitoes shows timing features that suggest that these processes are under circadian regulation as we find previously in Drosophila melanogaster 1,2 . Experimental verification for this is shown by temporal disruption of lightevoked attraction/avoidance behavior by environmentally shutting down the circadian clock with constant light (LL).…”

Section: Discussionsupporting

confidence: 73%

“…The color spectral specificity of attraction/avoidance behavior varies between different insect species 1,2,4,5,16 . Drosophila melanogaster diptera fruit flies avoid short wavelength light, but not long wavelength light and Drosophila UV light avoidance peaks in the midday during their low locomotor activity "siesta" 1,2 .…”

Section: Resultsmentioning

confidence: 99%

“…We anatomically mapped the circadian neuronal network in the central brain of female diurnal and nocturnal mosquitoes, motivated by the apparent relationship between the circadian clock and circuit modulation of light attraction/avoidance behavior, defined by the cyclic expression of PERIOD (PER) clock protein that drives rhythmic changes in physiology and behavior. In Drosophila melanogaster, Pigment Dispersing Factor (PDF) is a neuropeptide coexpressed with PER in the small-and large-lateral ventral neurons (LNvs), which modulate circadian-and light-mediated behaviors such as circadian locomotion, sleep, arousal, and lightevoked attraction/avoidance behaviors 1,2,[17][18][19][20] . PER and PDF proteins are co-expressed in a similar neuroanatomical pattern the lateral ventral area in both Ae.…”

Section: Resultsmentioning

confidence: 99%

“…night behavioral activity profiles of insects. Insects display a wide range of short wavelength light modulated behaviors, including attraction/avoidance [1][2][3][4][5][6][7] . It has been long assumed that insect responses to ultraviolet (UV) light are mediated by UV-sensitive opsins expressed in eyes and other external photoreceptors.…”

Section: Introductionmentioning

confidence: 99%

“…It has been long assumed that insect responses to ultraviolet (UV) light are mediated by UV-sensitive opsins expressed in eyes and other external photoreceptors. Mosquitoes and flies also express non-opsin photoreceptors including the blue-light sensitive flavoprotein CRYPTOCHROME (CRY) 8 which mediates a wide range of behavioral responses to blue and UV light, including circadian modulated attraction and avoidance 1,2 . Different mosquito species have evolved distinct circadian timing of behaviors according to their temporal/ecological niches, which likely minimize inter-species competition.…”

Section: Introductionmentioning

confidence: 99%

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Circadian regulation of light-evoked attraction/avoidance in day- vs. night-biting mosquitoes

Baik

Nave

et al. 2019

Preprint

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Mosquitoes pose widespread threats to humans and other animals as disease vectors. Day-vs. night-biting mosquitoes occupy distinct time-of-day niches and exhibit very different innate temporal attraction/avoidance behavioral responses to light, yet little is known about their circuit or molecular mechanisms. Day-biting diurnal mosquitoes Aedes aegypti are attracted to light during the day regardless of spectra. In contrast, night-biting nocturnal mosquitoes Anopheles coluzzii avoid short, but not long wavelength light. Attraction/avoidance behavioral responses to light in both species change with time-of-day and show distinct sex and circuit differences. The basis of diurnal versus nocturnal behavior is driven by clock timing, which cycle anti-phase between day-biting versus night-biting mosquito species. Disruption of the circadian molecular clock severely interferes with light-evoked attraction/avoidance behavior in mosquitoes. In summary, attraction/avoidance mosquito behaviors are circadian and light regulated, which may be applied towards species specific control of harmful mosquitoes.

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Section: Discussionsupporting

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Circadian regulation of light-evoked attraction/avoidance in day- vs. night-biting mosquitoes

Baik

Nave

et al. 2019

Preprint

Self Cite

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CRISPR/Cas9‐mediated knockout of LW‐opsin reduces the efficiency of phototaxis in the diamondback moth Plutella xylostella

Chen

Liu

Chen

et al. 2021

Pest Management Science

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BACKGROUND: Opsins are crucial for animal vision. The identity and function of opsins in Plutella xylostella remain unknown. The aim of the research is to confirm which opsin gene(s) contribute to phototaxis of P. xylostella.RESULTS: LW-opsin, BL-opsin and UV-opsin, were identified in the P. xylostella genome. LW-opsin was more highly expressed than the other two opsin genes, and all three genes were specifically expressed in the head. Three P. xylostella strains, LW-13 with a 13-bp deletion in LW-opsin, BL + 2 with a 2-bp insertion in BL-opsin, and UV-29 with a 5-bp insertion and a 34-bp deletion in UV-opsin, were established from the strain G88 using the CRISPR/Cas9 system. Among the three opsin-knockout strains, only male and female LW-13 exhibited weaker phototaxis to lights of different wavelengths and white light than G88 at 2.5 lx due to defective locomotion, and LW-13 was defective to sense white, green and infrared lights. The locomotion of LW-13 was reduced compared with G88 at 2.5, 10, 20, 60, 80, 100, and 200 lx under the green light, but the locomotion of LW-13 female was recovered at 80, 100 and 200 lx. The defective phototaxis to the green light of male LW-13 was not affected by light intensity, while the defective phototaxis to the green light of female LW-13 was recovered at 10, 20, 60, 80, 100, and 200 lx. CONCLUSION: LW-opsin is involved in light sensing and locomotion of P. xylostella, providing a potential target gene for controlling the pest.

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Light input pathways to the circadian clock of insects with an emphasis on the fruit fly Drosophila melanogaster

Helfrich‐Förster

2019

J Comp Physiol A

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Light is the most important Zeitgeber for entraining animal activity rhythms to the 24-h day. In all animals, the eyes are the main visual organs that are not only responsible for motion and colour (image) vision, but also transfer light information to the circadian clock in the brain. The way in which light entrains the circadian clock appears, however, variable in different species. As do vertebrates, insects possess extraretinal photoreceptors in addition to their eyes (and ocelli) that are sometimes located close to (underneath) the eyes, but sometimes even in the central brain. These extraretinal photoreceptors contribute to entrainment of their circadian clocks to different degrees. The fruit fly Drosophila melanogaster is special, because it expresses the blue light-sensitive cryptochrome (CRY) directly in its circadian clock neurons, and CRY is usually regarded as the fly's main circadian photoreceptor. Nevertheless, recent studies show that the retinal and extraretinal eyes transfer light information to almost every clock neuron and that the eyes are similarly important for entraining the fly's activity rhythm as in other insects, or more generally spoken in other animals. Here, I compare the light input pathways between selected insect species with a focus on Drosophila's special case.

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CRYPTOCHROME mediates behavioral executive choice in response to UV light

Cited by 48 publications

References 53 publications

Circadian regulation of light-evoked attraction/avoidance in day- vs. night-biting mosquitoes

Circadian regulation of light-evoked attraction/avoidance in day- vs. night-biting mosquitoes

CRISPR/Cas9‐mediated knockout of LW‐opsin reduces the efficiency of phototaxis in the diamondback moth Plutella xylostella

Light input pathways to the circadian clock of insects with an emphasis on the fruit fly Drosophila melanogaster

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