Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages

Zhao, Xuelian; Yu, Liang; Zhang, Sun-Dong; Kou, Ping; Ni, Haiyan; Qin, Xiangyu; Zhao, Chunjian; Wang, Wei; Efferth, Thomas; Fu, Yujie

doi:10.1016/j.intimp.2020.106436

Cited by 53 publications

(48 citation statements)

References 46 publications

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“…NCGA has exerted protective effect against lipopolysaccharide (LPS)induced inflammatory response via upregulation of Nrf2/HO-1 and involving the AMPK pathway (Park et al, 2018). CCGA is a special isomer of CGA, and the pharmacological effects and related molecular mechanisms of CCGA have been poorly reported (Zhao et al, 2020). An earlier study has reported that CCGA exerts its effect against LPS-induced oxidative stress and inflammation (Zhao et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy

Wang

Paudel

et al. 2021

Front. Mol. Biosci.

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Lead (Pb) is among the deleterious heavy metal and has caused global health concerns due to its tendency to cause a detrimental effect on the development of the central nervous system (CNS). Despite being a serious health concern, treatment of Pb poisoning is not yet available, reflecting the pressing need for compounds that can relieve Pb-induced toxicity, especially neurotoxicity. In the quest of exploring protective strategies against Pb-induced developmental neurotoxicity, compounds from natural resources have gained increased attention. Chlorogenic acid (CGA) and its analogues neochlorogenic acid (NCGA) and cryptochlorogenic acid (CCGA) are the important phenolic compounds widely distributed in plants. Herein, utilizing zebrafish as a model organism, we modeled Pb-induced developmental neurotoxicity and investigated the protective effect of CGA, NCGA, and CCGA co-treatment. In zebrafish, Pb exposure (1,000 μg/L) for 5 days causes developmental malformation, loss of dopaminergic (DA) neurons, and brain vasculature, as well as disrupted neuron differentiation in the CNS. Additionally, Pb-treated zebrafish exhibited abnormal locomotion. Notably, co-treatment with CGA (100 µM), NCGA (100 µM), and CCGA (50 µM) alleviated these developmental malformation and neurotoxicity induced by Pb. Further underlying mechanism investigation revealed that these dietary phenolic acid compounds may ameliorate Pb-induced oxidative stress and autophagy in zebrafish, therefore protecting against Pb-induced developmental neurotoxicity. In general, our study indicates that CGA, NCGA, and CCGA could be promising agents for treating neurotoxicity induced by Pb, and CCGA shows the strongest detoxifying activity.

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Section: Introductionmentioning

confidence: 99%

“…CCGA is a special isomer of CGA, and the pharmacological effects and related molecular mechanisms of CCGA have been poorly reported (Zhao et al, 2020). An earlier study has reported that CCGA exerts its effect against LPS-induced oxidative stress and inflammation (Zhao et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy

Wang

Paudel

et al. 2021

Front. Mol. Biosci.

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“…Three major phenolic compounds, nCGA, cCGA, and CGA, have been identified in the mulberry leaf extract [ 11 ]. A previous study shows that nCGA and cCGA inhibit the production of IL-1 β , IL-6, and TNF α by macrophages and reduces the cellular reactive oxygen species via upregulation of the Nrf2/HO-1 signaling [ 26 , 27 ]. In addition, chlorogenic acid can reduce hepatic inflammation, hepatic lipid accumulation, and plasma hepatic enzyme activities in obese rats, but it does not change the plasma lipid profile [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Aqueous Mulberry Leaf Extract Ameliorates Alcoholic Liver Injury Associating with Upregulation of Ethanol Metabolism and Suppression of Hepatic Lipogenesis

Lee

Tsai

Lin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Excessive alcohol intake is a major cause of chronic liver damage and is highly associated with the development of a spectrum of hepatic disorders, including steatohepatitis, liver cirrhosis, and liver cancer. Thus, we aimed to explore the hepatoprotective effects of an aqueous mulberry leaf extract (AME) on alcoholic fatty liver disorder (AFLD) by using a mouse model fed with excessive ethanol. Compared with the normal diet, the ethanol diet significantly increased the body weight of the mice, while the AME supplement reduced the weight gain caused by the ethanol diet. The ethanol diet also attenuated the activity of alcohol dehydrogenase and antioxidant enzymes but increased lipid peroxidation in the liver, which were reversed by AME supplementation. Additionally, AME supplementation diminished the ethanol diet-induced hepatic leukocyte infiltration and expressions of IL-6 and TNFα. Moreover, AME supplementation also reduced the ethanol-diet-induced lipid accumulation and expression of 1-acylglycerol-3-phosphate acyltransferase, acetyl-CoA carboxylase, low-density lipoprotein receptor, and sterol regulatory element-binding protein-1/2 in the liver. Collectively, AME supplementation improved liver lipid accumulation and proinflammatory response in mice induced by the ethanol diet, which was associated with the upregulation of ethanol-metabolizing enzymes and the downregulation of lipogenesis components.

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“…Gallic acid is also known to reduce symptoms of inflammation like, pain and swelling ( Choubey et al, 2015 ). Both neochlorogenic and cryptochlorogenic acids suppress inflammation through activation of the AMPK/Nrf2/HO1 pathway ( Kim et al, 2015 ; Gao et al, 2020 ; Zhao et al, 2020 ). Vanillic acid can reduce inflammatory pain by inhibiting neutrophil recruitment, oxidative stress, cytokine production, and NF-κB activation ( Calixto-Campos et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response

et al. 2020

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The widely used cancer treatment, chemotherapy, causes severe long-term neuropathic pain in 30–40% cases, the condition clinically known as chemotherapy-induced peripheral neuropathy (CIPN). Approved conventional analgesics are sometimes ineffective, while others like opioids have undesirable side effects like addiction, seizures, and respiratory malfunctioning. Tricyclic antidepressants and anticonvulsants, although exhibit anti-allodynic effects in neuropathy, also have unpleasant side effects. Thus, alternative medicines are being explored for CIPN treatment. Despite scattered reports on different extracts from different plants having potential anti-allodynic effects against CIPN, no established medicine or formulation of herbal origin exists. In this study, efficacy of an herbal decoction, formulated based on ancient medicinal principles and protocols for treating neuropathic pain, Divya-Peedantak-Kwath (DPK), has been evaluated in a paclitaxel (PTX)-induced peripheral neuropathic mouse model. We observed that DPK has prominent anti-allodynic and anti-hyperalgesic effects and acts as a nociceptive modulator for CIPN. With exhibited antioxidative effects, DPK restored the redox potential of the sciatic nerves to the normal. On histopathological evaluation, DPK prevented the PTX-induced lesions in the sciatic nerve, in a dose-dependent manner. It also prevented inflammation by modulating the levels of pro-inflammatory cytokines involved in CIPN pathogenesis. Our observations evinced that DPK can alleviate CIPN by attenuating oxidative stress and concomitant neuroinflammation through immune modulation.

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Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages

Cited by 53 publications

References 46 publications

Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy

Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy

Aqueous Mulberry Leaf Extract Ameliorates Alcoholic Liver Injury Associating with Upregulation of Ethanol Metabolism and Suppression of Hepatic Lipogenesis

Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response

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