Cryptochlorogenic acid and its metabolites ameliorate myocardial hypertrophy through a HIF1α-related pathway

Li, Jie; Chen, Xiaohe; Li, Xiang; Tang, Jiayang; Li, Yan; Liu, Bin; Guo, Shuzhen

doi:10.1039/d1fo03838a

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…Its pharmacological effects include improvement in the blood glucose levels, iron content, and lipid peroxide accumulation via activation of the system XC/glutathione peroxidase 4/factor-erythroid factor 2 system in patients with diabetes [ 57 ]. Additionally, 4-CQA attenuates LPS-induced inflammatory responses and oxidative stress and ameliorates myocardial hypertrophy through a hypoxia-inducible factor 1 subunit alpha-related pathway [ 57 , 58 ]. The anti-inflammatory effects of 4-CQA may be attributed to its ability to inhibit OA through MF-mediated inflammatory signaling regulation.…”

Section: Discussionmentioning

confidence: 99%

Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes

Park,

Choi,

Yeo

et al. 2024

PLoS ONE

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Osteoarthritis is the most prevalent type of degenerative arthritis. It is characterized by persistent pain, joint dysfunction, and physical disability. Pain relief and inflammation control are prioritised during osteoarthritis treatment Mume Fructus (Omae), a fumigated product of the Prunus mume fruit, is used as a traditional medicine in several Asian countries. However, its therapeutic mechanism of action and effects on osteoarthritis and articular chondrocytes remain unknown. In this study, we analyzed the anti-osteoarthritis and articular regenerative effects of Mume Fructus extract on rat chondrocytes. Mume Fructus treatment reduced the interleukin-1β-induced expression of matrix metalloproteinase 3, matrix metalloproteinase 13, and a disintegrin and metalloproteinase with thrombospondin type 1 motifs 5. Additionally, it enhanced collagen type II alpha 1 chain and aggrecan accumulation in rat chondrocytes. Furthermore, Mume Fructus treatment regulated the inflammatory cytokine levels, mitogen-activated protein kinase phosphorylation, and nuclear factor-kappa B activation. Overall, our results demonstrated that Mume Fructus inhibits osteoarthritis progression by inhibiting the nuclear factor-kappa B and mitogen-activated protein kinase pathways to reduce the levels of inflammatory cytokines and prevent cartilage degeneration. Therefore, Mume Fructus may be a potential therapeutic option for osteoarthritis.

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Section: Discussionmentioning

confidence: 99%

Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes

Park,

Choi,

Yeo

et al. 2024

PLoS ONE

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“…41,42 HIF-1a/Hippo signaling pathway plays a crucial role in cardiac hypertrophy development. 13,14,43 Chu et al 44 provide evidence for a new discovery of the HIF-1a signal can be activated in cardiomyocytes on hypoxia stimulation, resulting in hypertrophic remodeling. Todd et al demonstrated that Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.…”

Section: Discussionmentioning

confidence: 99%

Ectopic Acsl6 overexpression partially improves Isoproterenol (ISO)-induced cardiac hypertrophy in vivo and cardiomyocyte hypertrophy in vitro

Liu

Long

et al. 2022

Journal of Cardiovascular Pharmacology

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The increase in cardiac myocyte size is a critical issue in cardiac hypertrophy development. In this study, 61 differentially expressed genes between hypertrophic rats and normal controls were enriched in the positive modulation of fatty acid uptake, fatty acid metabolism and degradation, cardiac conduction, and the oxidation of carbohydrates and other processes. Acsl6 was significantly downregulated in hypertrophic rat and mouse hearts according to online data. Based on the experimental data, Acsl6 was underexpressed in ISO-induced cardiac hypertrophy mouse model and isoproterenol (ISO)-induced cardiomyocyte hypertrophy cell model. In vivo, Acsl6 overexpression partially attenuated ISO-induced increases in the cross-sectional area and cardiac hypertrophy, elevated hypertrophic markers, and caused impairment of cardiac function. In vitro, Acsl6 overexpression partially attenuated ISOinduced cardiomyocyte hypertrophy and increased hypertrophic markers. Conclusively, Ascl6 is downregulated in ISO-induced cardiac hypertrophy mouse model and ISO-induced cardiomyocyte hypertrophy cell model. Acsl6 overexpression could partially improve cardiac hypertrophy in vivo and cardiomyocyte hypertrophy in vitro, possibly through the regulation of HIF-1a/Hippo pathway.

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“…Furthermore, CGA has demonstrated notable efficacy in improving cardiac hypertrophy induced by ISO through the Akt/mammalian target of rapamycin (mTOR)/HIF-1α pathway. It also provides protection in patients with diabetic cardiomyopathy (DCM) by inhibiting glycosylation, modulating the PKCα- extracellular regulated protein kinases (ERK) signaling pathway, and exerting antioxidant effects [ 179 , 180 ]. In experimental models, CGA has shown considerable reductions in pro-inflammatory cytokines, MI size, OS, and mitochondrial respiratory defects, while simultaneously enhancing antioxidant enzyme activity to protect the damaged myocardium [ 181 , 182 ].…”

Section: Antioxidant Treatmentmentioning

confidence: 99%

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Yan

Sun

et al. 2023

J Transl Med

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Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarction (MI). Oxidative stress (OS) plays a crucial role in the pathogenesis and advancement of CVDs, highlighting its significance as a contributing factor. Maintaining an equilibrium between reactive oxygen species (ROS) and antioxidant systems not only aids in mitigating oxidative stress but also confers protective benefits on cardiac health. Herbal monomers can inhibit OS in CVDs by activating multiple signaling pathways, such as increasing the activity of endogenous antioxidant systems and decreasing the level of ROS expression. Given the actions of herbal monomers to significantly protect the normal function of the heart and reduce the damage caused by OS to the organism. Hence, it is imperative to recognize the significance of herbal monomers as prospective therapeutic interventions for mitigating oxidative damage in CVDs. This paper aims to comprehensively review the origins and mechanisms underlying OS, elucidate the intricate association between CVDs and OS, and explore the therapeutic potential of antioxidant treatment utilizing herbal monomers. Furthermore, particular emphasis will be placed on examining the cardioprotective effects of herbal monomers by evaluating their impact on cardiac signaling pathways subsequent to treatment. Graphical Abstract

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Cryptochlorogenic acid and its metabolites ameliorate myocardial hypertrophy through a HIF1α-related pathway

Abstract: Cryptochlorogenic acid (4-CQA) is a type of phenolic acid that has antioxidant and anti-inflammatory activities. Our preliminary study found that 4-CQA has a good effect on isoproterenol (ISO)-induced myocardial hypertrophy...

Cited by 8 publications

References 27 publications

Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes

Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes

Ectopic Acsl6 overexpression partially improves Isoproterenol (ISO)-induced cardiac hypertrophy in vivo and cardiomyocyte hypertrophy in vitro

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

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