DOI: 10.1101/2021.05.24.445519
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Abstract: Genetic variations expand the conformational landscape of proteins and may underlie cryptic functions able to influence protein adaptability under unfavorable conditions. Cryptic functions usually associate with regions of increased frustration or even intrinsically disordered, whose role as drivers of innovation is increasingly being recognized. Hence, the balance between protein stability and controlled disorder translates in the dichotomy between conservation and innovability, and should be regarded as the … Show more

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