“…TDP-43 is a major mRNA splicing regulator, and changes in splicing are found in TDP-43 proteinopathies including ALS, FTLD-TDP, and LATE ( Chang et al, 2023 ; Chung et al, 2024 ; Mehta et al, 2023 ). We evaluated transcriptomic data from tau Tg, TDP-43 Tg, and tau-TDP-43 Tg animals for alternative splicing using established analysis methods (DEXSeq and SpliceWiz) ( Anders et al, 2012 ; Wong et al, 2024 ).…”