Cryotreatment of keloids: a single Italian institution experience

Fraccalvieri, Marco; Bogetti, Paolo; Salomone, Marco; Santo, Claudia Di; Ruka, Erind; Bruschi, Stefano

doi:10.1007/s00238-015-1170-6

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…Keloids are probably associated with an abnormal wound-healing process as a result of skin injury such as piercings, abrasions, burning, surgery, tattoos, insect bites, or any processes causing skin inflammation. 2 …”

Section: Introductionmentioning

confidence: 99%

“…Keloids are probably associated with an abnormal woundhealing process as a result of skin injury such as piercings, abrasions, burning, surgery, tattoos, insect bites, or any processes causing skin inflammation. 2 Keloid scar management is clinically challenging. Many treatment lines have been advocated either alone or in conjunction with others, including surgical excision, cryotherapy, radiotherapy, intralesional chemotherapeutic injection, laser therapy, topical silicone, systemic chemotherapy and pressure therapy.…”

Section: Introductionmentioning

confidence: 99%

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Evaluating serum level of thymidylate synthase in post burn keloid patients before and after intralesional injection of 5-fluorouracil

Mohamad

Raheem

Mahmoud

et al. 2022

Scars, Burns & Healing

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Background Keloids are fibrous lesions formed at the site of trauma due to types I and III collagen irregular production. The presence of thymidylate synthase (TS) is a must for DNA synthesis and repairs causing cell death. 5-fluorouracil (5-FU) is a fluorinated pyrimidine analogue acting as an anti-metabolic agent that inhibits thymidylate synthase and interferes with ribo-nucleic acid (RNA) synthesis. Objectives we aimed to evaluate the level of thymidylate synthase in post burn keloid patients before and after intralesional injection of 5-fluorouracil. Methods The study included 20 keloid patients and 20 healthy subjects as a control. Serum TS was estimated using commercially available enzyme-linked immunosorbent assay (ELISA) kits before and after treatment with 5-fluorouracil. Results There was a statistically significant difference in TS levels before and after 5-FU treatment (p < 0.05). Also, results have shown that 5-FU injection has good satisfactory results in treatment of keloid causing reduction in scar volume and symptoms improvement (90% of the patients improved). On the other hand, there was no statistically significant difference in TS levels and the outcomes of the treatment. Conclusion Our findings suggest that intralesional 5-FU injection in keloid has very satisfactory results. However, thymidylate synthase enzyme has a minimal role in evaluating the treatment of keloid, so further studies are required to elaborate the relation between this enzyme and keloid scars.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluating serum level of thymidylate synthase in post burn keloid patients before and after intralesional injection of 5-fluorouracil

Mohamad

Raheem

Mahmoud

et al. 2022

Scars, Burns & Healing

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Intralesional cryosurgery for the treatment of keloid scars following cochlear implant surgery and removal of cholesteatoma

2016

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A new treatment of hypertrophic and keloid scars with combined triamcinolone and verapamil: a retrospective study

et al. 2017

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BackgroundSince the management of keloid and hypertrophic scars still remains a difficult clinical problem, there is need for adequate, effective therapy. In this study, we explored for the first time the efficacy and the potential synergetic effect of combined triamcinolone and verapamil for the treatment of hypertrophic and keloid scars. The objective was to assess the efficacy of combined intralesional triamcinolone and verapamil therapy for hypertrophic and keloid scars.MethodsFifty-eight patients with hypertrophic scars (n = 31) and keloid scars (n = 27) were included. A specific injection therapy scheme was applied. Five follow-up moments were chosen, with a maximum follow-up of nearly 2 years. The effects of combination therapy on scar pliability, thickness, relief, vascularization, surface area, pain, and pruritus were examined by means of the Patient and Observer Scar Assessment Scale (POSAS).ResultsOur results reveal a fast and abiding improvement of both keloid and hypertrophic scars after treatment with the combination therapy. All POSAS components showed a reduction in scar score, while scar relief, pain, itchiness, and surface area improved significantly (P < 0.05) in keloids. Significant improvement in hypertrophic scars was found in scar pigmentation, vascularization, pliability, thickness, pain, and surface area. Overall POSAS scores revealed statistically significant decreases between baseline and 3–4 months, 4–6 months, and >12 months after start of therapy in both keloids and hypertrophic scars.ConclusionsThis study reveals that combined therapy of triamcinolone and verapamil results in overall significant scar improvement with a long-term stable result.Level of evidence: Level IV, therapeutic study.

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Cryotreatment of keloids: a single Italian institution experience

Cited by 5 publications

References 16 publications

Evaluating serum level of thymidylate synthase in post burn keloid patients before and after intralesional injection of 5-fluorouracil

Evaluating serum level of thymidylate synthase in post burn keloid patients before and after intralesional injection of 5-fluorouracil

Intralesional cryosurgery for the treatment of keloid scars following cochlear implant surgery and removal of cholesteatoma

A new treatment of hypertrophic and keloid scars with combined triamcinolone and verapamil: a retrospective study

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