Cryotherapy vs trichloroacetic acid 90% in treatment of common warts

Meguid, Azza Mahfouz Abdel; Motaleb, Amira A Abdel; Sadek, Amany Mohamed Ibrahim Abdel

doi:10.1111/jocd.12805

Cited by 9 publications

(5 citation statements)

References 16 publications

(18 reference statements)

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“…In our study, the reported adverse effects including blister, pain, erythema, and ulcers in the TCA 40% group was significantly lower as compared to the Cryo group. Inconsistent with our study, the occurrence of side effects (erythema, pain, erosions, bulla, and hyperpigmentation) in the studies by Cengiz and Emiroglu, 15 Cengiz et al, 14 and Abdel Meguid et al 16 was reported greater in Cryo group vs TCA group. Moreover, itching and hyperpigmentation were reported more frequently in the TCA group.…”

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

“…In a study conducted by Abdel Meguid 16 the effect of Cryo with TCA 90% in the treatment of common warts was compared. Conversely, they found Cryo more effective than TCA 90% (90% vs 26%), after 4 weeks of treatment 16 . The same results were obtained by some other studies on common warts, and since common warts are more common on hands, it is assumed that Cryo is more effective on warts located on hands 17,18 …”

Section: Discussionmentioning

confidence: 99%

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Comparison of 40% trichloroacetic acid and cryotherapy for the treatment of plantar warts: A single‐blind, randomized clinical trial

Karrabi

Kheirkhah

Shahrestanaki

et al. 2020

Dermatologic Therapy

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Plantar warts can cause pain near the toes and the sole of the foot and may result in referral for treatment. This study was aimed at comparing 40% trichloroacetic acid (TCA) and cryotherapy (Cryo) for the treatment of plantar warts. This single‐blind, randomized clinical trial was performed on 60 subjects presenting with plantar wart in Sabzevar, Iran in 2018. The first intervention group was treated with 40% TCA in four sessions within 4 weeks. The second intervention group was treated with Cryo using liquid nitrogen in four sessions within 8 weeks. The mean (SD) age of subjects was 20.16 ± 5.96 years and 68.33% (n = 41) were male. Although the resolution rate of warts in the TCA 40% group was greater than the Cryo group, there was no statistical association found between the two groups by adjusting age, sex, and basal time (P = .648). Findings suggest that although 40% TCA was almost as effective as Cryo in the treatment of plantar warts, considering the lower adverse effects of TCA 40% group as compared to the Cryo group, it could be a proper alternative.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of 40% trichloroacetic acid and cryotherapy for the treatment of plantar warts: A single‐blind, randomized clinical trial

Karrabi

Kheirkhah

Shahrestanaki

et al. 2020

Dermatologic Therapy

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“…Warts treated by cryotherapy once a week had faster recovery than once every 2–3 weeks while the overall cure rate depended on the total repeated times of treatments rather than the time interval. A meta‐analysis on one nonrandomized controlled trial 65 and two RCTs 61 , 66 showed that the effectiveness of liquid nitrogen cryotherapy in the treatment of common warts was significantly higher than noncryotherapy methods ( I 2 = 90%, RR = 2.01, 95% CI [1.02, 3.97], p = 0.04), as topical trichloroacetic acid and intralesional injection of Candida antigen. A cohort study 67 concluded that shorter freezing time (10 s) and interval (2 weeks) of cryotherapy was more effective than longer freezing time (20 s) and intervals (4 weeks), for treating common viral warts on hand and foot.…”

Section: Resultsmentioning

confidence: 99%

Clinical guideline for the diagnosis and treatment of cutaneous warts (2022)

Zhu

Yang

et al. 2022

J Evidence Based Medicine

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Aim Cutaneous warts caused by human papillomavirus are benign proliferative lesions that occur at any ages in human lives. Updated, comprehensive and systematic evidence‐based guidelines to guide clinical practice are urgently needed. Methods We collaborated with multidisciplinary experts to formulate this guideline based on evidences of already published literature, focusing on 13 clinical questions elected by a panel of experts. We adopted Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to form classification of recommendations as well as the improved Delphi method to retain respective recommendations with a consensus degree of over 80%. Results Our guideline covered aspects of the diagnosis and treatment of cutaneous warts such as diagnostic gold standard, transmission routes, laboratory tests, treatment principle, clinical cure criterion, definitions, and treatments of common warts, flat warts, plantar warts, condyloma acuminatum, and epidermodysplasia verruciformis. Recommendations about special population such as children and pregnant women are also listed. In total, 49 recommendations have been obtained. Conclusions It is a comprehensive and systematic evidence‐based guideline and we hope this guideline could systematically and effectively guide the clinical practice of cutaneous warts and improve the overall levels of medical services.

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“…We suggest that the local application of TCA in the nasal cavity in a concentration of either 50% or 80% for about 1 min may preclude or markedly reduce the entry of SARS‐CoV‐2 and destroy the virus itself. TCA has been proved to be effective and safe and has been used for years in the treatment of viral‐driven lesions, especially in a sensitive mucosa 58‐64 …”

mentioning

confidence: 99%

COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

Abdelhadi

Ruszczak

Schwartz

2020

Dermatologic Therapy

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Since the spread of SARS‐CoV‐2 became a pandemic, the number of cases has been continuously growing worldwide. Numerous recommendations and suggestions have been published to prevent the acquisition and spread of the SARS‐CoV‐2, especially to protect health workers and front‐line caregivers. SARS‐CoV‐2 is transmitted by aerosol, rendering air defense with suitable ventilation and adequate mask use pivotal. Recently, locally applied antiseptic, antiviral, or structure competitive receptor blockers were suggested to attack the virus at its main point of invasion, the nasal mucosa and nasopharynx. We discuss the most plausible and safe ideas to reduce viral load at the point of entry, and subsequently the spread of SARS‐CoV‐2 to the lower respiratory tract, lungs, and other organs. In addition, we analyze the value and recommend clinical trials employing topical trichloroacetic acid (TCA), a substance well known from dermatologic and cosmetic procedures. It has been proven to successfully block the nasal entry for airborne allergens, preventing the development of allergic rhinitis and asthma, and to be curative for early stages of viral infections entering through the oral mucosa. For SARS‐CoV‐2, TCA in a single, short‐time application is expected to remodel the nasal and nasopharyngeal epithelia, eliminating both the receptors and cells responsible for viral entry and subsequent viral spread to the lower respiratory tract. Moreover, this may have therapeutic benefits for those recently infected by reducing local viral replication. Such procedures are cheap, safe, and can be conducted in almost every setting, especially in regions with inadequate financial and logistic resources.

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Cryotherapy vs trichloroacetic acid 90% in treatment of common warts

Cited by 9 publications

References 16 publications

Comparison of 40% trichloroacetic acid and cryotherapy for the treatment of plantar warts: A single‐blind, randomized clinical trial

Comparison of 40% trichloroacetic acid and cryotherapy for the treatment of plantar warts: A single‐blind, randomized clinical trial

Clinical guideline for the diagnosis and treatment of cutaneous warts (2022)

COVID ‐19: Topical agents and therapeutic prevention of nasal viral acquisition

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