Cryotherapy of cardiac arrhythmia: From basic science to the bedside

Avitall, Boaz; Kalinski, Arthur

doi:10.1016/j.hrthm.2015.05.034

Cited by 67 publications

(51 citation statements)

References 53 publications

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“…The mechanism of cryoablation differs considerably from that of RF ablation. In contrast to RF ablation, cryotechnologies remove heat from tissue, lowering the molecular movement and stored kinetic energy, which results in tissue cooling and ice formation . The mechanisms of lesion formation by cryoenergy are highly complex and result in distinct lesion qualities advantageous to RF .…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Vein Isolation Using a Second‐Generation Cryoballoon in Patients With Paroxysmal Atrial Fibrillation: One‐Year Outcome Using a Single Big‐Balloon 3‐Minute Freeze Technique

Miyazaki

Hishida

Nakamura

et al. 2016

Cardiovasc electrophysiol

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Section: Discussionmentioning

confidence: 99%

Pulmonary Vein Isolation Using a Second‐Generation Cryoballoon in Patients With Paroxysmal Atrial Fibrillation: One‐Year Outcome Using a Single Big‐Balloon 3‐Minute Freeze Technique

Miyazaki

Hishida

Nakamura

et al. 2016

Cardiovasc electrophysiol

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“…Given the relationship between the time course and mechanism involving cryolesion tissue injury, 19 the inflammation after the cryoenergy application around the ganglionated plexus may have induced an imbalance of the autonomic nervous system, which could have been the mechanism of the coronary spasms after the cryoballoon ablation procedure.…”

Section: Discussionmentioning

confidence: 99%

Recurrent and late-onset coronary spasms after cryoballoon ablation procedure in a patient with atrial fibrillation

Watanabe

Miyazaki

Nakamura

et al. 2016

HeartRhythm Case Reports

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“…29 It has been reported that cryolesions are distinguished from hyperthermic injury by the preservation of the basic underlying tissue architecture with preserved endocardial contours, minimal cartilage formation, and the absence of signs of chronic inflammation or evidence of viable myocytes within the lesions, which can result in minimal tissue shrinkage and PV contraction in comparison with radiofrequency lesions. [29][30][31] Although the true mechanism of the PV narrowing that was observed in the present study remains to be elucidated, we found that the baseline PV size and the MFT were significantly associated with the occurrence of PV narrowing in the present system of cryoballoon ablation. At the very least, need to keep in mind that cryoballoon ablation can cause PV narrowing/stenosis in human PVI procedures.…”

Section: Mechanism Of Pv Stenosis After Cryoballoon Ablationmentioning

confidence: 99%

Incidence and Factors Associated With the Occurrence of Pulmonary Vein Narrowing After Cryoballoon Ablation

Narui

Tokuda

Matsushima

et al. 2017

Circ: Arrhythmia and Electrophysiology

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Background-In contrast with traditional radiofrequency ablation, little is known about the influence of cryoballoon ablation on the morphology of pulmonary veins (PVs). We evaluated the influence of cryoballoon ablation on the PV dimension (PVD) and investigated the factors associated with a reduction of the PVD. Methods and Results-Seventy-four patients who underwent cryoballoon ablation for paroxysmal atrial fibrillation were included in the present study. All subjects underwent contrast-enhanced computed tomography both before and at 3 months after the procedure. The PVD (cross-sectional area) was measured using a 3-dimensional electroanatomical mapping system. Each PV was evaluated according to the PVD reduction rate (ΔPVD), which was calculated as follows: (1−post-PVD/pre-PVD)×100 (%). Ninety-two percent of the PVs (271/296) were successfully isolated only by cryoballoon ablation; the remaining 8% of the PVs required touch-up ablation and were excluded from the analysis. Mild (25%-50%), moderate (50%-75%), and severe (≥75%) ΔPVD values were observed in 87, 14, and 3 PVs, respectively, including 1 case with severe left superior PV stenosis (ΔPVD: 94%) in a patient who required PV angioplasty. In multivariable analysis, a larger PV ostium and lower minimum freezing temperature during cryoballoon ablation were independently associated with PV narrowing (odds ratio, 1.773; P=0.01; and odds ratio, 1.137; P<0.001, respectively). Conclusions-A reduction of the PVD was often observed after cryoballoon ablation for atrial fibrillation. A larger PV ostium and lower minimum freezing temperature during cryoballoon ablation were associated with an increased risk of PVD reduction.

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Cryotherapy of cardiac arrhythmia: From basic science to the bedside

Cited by 67 publications

References 53 publications

Pulmonary Vein Isolation Using a Second‐Generation Cryoballoon in Patients With Paroxysmal Atrial Fibrillation: One‐Year Outcome Using a Single Big‐Balloon 3‐Minute Freeze Technique

Pulmonary Vein Isolation Using a Second‐Generation Cryoballoon in Patients With Paroxysmal Atrial Fibrillation: One‐Year Outcome Using a Single Big‐Balloon 3‐Minute Freeze Technique

Recurrent and late-onset coronary spasms after cryoballoon ablation procedure in a patient with atrial fibrillation

Incidence and Factors Associated With the Occurrence of Pulmonary Vein Narrowing After Cryoballoon Ablation

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