Cryotherapy-Induced Release of Epiretinal Membrane Associated With Retinal Vasoproliferative Tumor

Manjandavida, Fairooz P; Shields, Carol L.; Kaliki, Swathi; Shields, Jerry A.

doi:10.1097/iae.0000000000000137

Cited by 22 publications

(16 citation statements)

References 33 publications

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“…10 Cryotherapy is also known to be an effective treatment for VPT, and it has been reported that the tension created by a VPT-related epiretinal membrane (ERM) was released in 63% of the cases after cryotherapy. 8 In our case, the cryotherapy released the vitreoretinal traction but a MH still developed.…”

Section: Discussionmentioning

confidence: 51%

<p>Macular Hole Formation in Eye After Cryotherapy and Intravitreal Bevacizumab Treatment for Vasoproliferative Tumor</p>

Sato¹,

Fukui²,

Ohta³

2020

IMCRJ

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To report a case of a full-thickness macular hole (MH) that developed after cryotherapy and intravitreal bevacizumab injection (IVB) to treat a retinal vasoproliferative tumor (VPT). Methods: Case report of a man with a retinal VPT. Results: A 64-year-old Japanese man complained of blurred vision in his right eye. At the initial examination, his best-corrected visual acuity (BCVA) was 20/25 in the right eye and 20/20 in the left eye. Ophthalmoscopy showed a VPT in the lower peripheral retina of the right eye. An exudative retinal detachment and hard exudates were seen around the tumor. Cryotherapy and intravitreal injections of bevacizumab (IVB) were performed. Although the exudative changes were reduced, a MH developed two months after the initial IVB treatment. He underwent 25-gauge pars plana vitrectomy, and the MH was closed. His postoperative BCVA was 20/32 and the VPT was inactive. The reduced BCVA was due to damage of the outer retinal layers. Conclusion: Our findings indicate that cryotherapy and IVB are effective treatments for VPT although the possibility of developing a MH should be considered.

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Section: Discussionmentioning

confidence: 51%

<p>Macular Hole Formation in Eye After Cryotherapy and Intravitreal Bevacizumab Treatment for Vasoproliferative Tumor</p>

Sato¹,

Fukui²,

Ohta³

2020

IMCRJ

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“…Previous reports of VPT complicated with ERM showed a mean of 5 months duration between the time of developing visual symptoms and the diagnosis of VPT. 12 In our study, the two cases with complicated ERM (Case 1, Case 4) were younger and had visual loss due to rapid ERM formation in an average of 5 weeks (4 weeks, and 6 weeks). In addition, there was no PVD during VT in these two cases.…”

Section: Discussionmentioning

confidence: 61%

Clinical characters and treatments of retinal vasoproliferative tumors

Huang

Chen

2016

Taiwan Journal of Ophthalmology

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Retinal vasoproliferative tumors (VPT) are uncommon benign vascular tumors. They mostly occur in healthy patients, but may be associated with other chorioretinal diseases. Here we report four patients with VPT at a referral center from 2006 to 2015. Three patients denied any past history and one had a history of retinal detachment surgery. VPT-related complications included epiretinal membrane (ERM) (n = 2), cystoids macular edema (n = 1), and lamellar hole combined with dense cataract, rigid anterior capsule and vitreous opacity (n = 1). Treatments for VPT and comorbidities included vitrectomy (VT) and membrane peeling with tumor resection (n = 2), a combined treatment of photodynamic therapy (PDT) and intravitreal injection (IVI) of anti-vascular endothelial growth factor (anti-VEGF) (n = 2). Tumor shrinkage was achieved in both patients treated with PDT and IVI of anti-VEGF injection. The other two patients with ERM were successfully treated with VT and tumor resection. Visual acuity improved at least two lines in three patients, and one patient had decreased vision due to cataract formation after VT. Pathology of the resected tumor in one case revealed massive gliosis with positive stain of vascular endothelial cells and glial fibrillary acidic protein stain. Yet the peeled membrane was acellular. Possible beneficial treatments for VPT and comorbidities include PDT combined with IVI of anti-VEGF, or VT and membrane peeling with tumor resection.

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“…For those with leakage, we recommend treating the tumor first with cryotherapy or other methods, as this can cause tumor involution as well as release of vitreomacular traction, presumably from induction or completion of posterior vitreous detachment, and prevent recurrence of macular edema or re-proliferation of ERMs by inhibition of vasoactive and inflammatory material from the VPT. [9]…”

Section: Discussionmentioning

confidence: 99%

Role of pars plana vitrectomy and membrane peel in vitreomacular traction associated with retinal vasoproliferative tumors

Castro-Navarro¹,

Saktanasate²,

Say³

et al. 2016

Oman J Ophthalmol

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To report a case of retinal vasoproliferative tumor (VPT) with secondary epiretinal membrane (ERM) formation and vitreo-macular traction managed by pars plana vitrectomy (PPV) and membrane peel. A 29-year-old male was referred for management of decreased vision in the right eye (OD) for 1 week. Presenting visual acuity was 20/50 Snellen feet (ft) OD, and fundus examination showed an ERM associated with a reddish-yellow mass in the inferotemporal quadrant with overlying exudation, hemorrhage, and subretinal fluid consistent with VPT, and cryotherapy was recommended. Two months later, there was complete tumor regression, but there was decreased vision from progressive vitreomacular traction to 20/400 ft. PPV with combined ERM and internal limiting membrane (ILM) peel were performed with resolution of vitreomacular traction and improvement of visual acuity to 20/50 ft at 6 months. PPV with combined ERM and ILM peel is effective for vision loss secondary to ERM and vitreomacular traction associated with retinal VPT.

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Cryotherapy-Induced Release of Epiretinal Membrane Associated With Retinal Vasoproliferative Tumor

Abstract: Cryotherapy is remarkably effective for VPT of 6 mm or less in basal dimension. After cryotherapy, VPT-related ERM spontaneously released in 63% of the cases, without the need for surgical intervention.

Cited by 22 publications

References 33 publications

<p>Macular Hole Formation in Eye After Cryotherapy and Intravitreal Bevacizumab Treatment for Vasoproliferative Tumor</p>

<p>Macular Hole Formation in Eye After Cryotherapy and Intravitreal Bevacizumab Treatment for Vasoproliferative Tumor</p>

Clinical characters and treatments of retinal vasoproliferative tumors

Role of pars plana vitrectomy and membrane peel in vitreomacular traction associated with retinal vasoproliferative tumors

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