Cryotherapy for docetaxel-induced hand and nail toxicity: randomised control trial

McCarthy, Alexandra; Shaban, Ramon Z.; Gillespie, Kerri; Vick, Joanne

doi:10.1007/s00520-013-2095-x

Cited by 29 publications

(33 citation statements)

References 17 publications

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“…Most of these studies were excluded from our final review for the following reasons: 10 were retrospective or review studies, one evaluated ST and NT caused by epidermal growth factor receptor inhibitors, and two compared the outcomes of different degrees of cryotherapy for prevention of docetaxel‐induced NT. The remaining nine studies were finally selected for our meta‐analysis (Can et al, ; Hayashi et al, ; Kim et al, ; Matsumoto et al, ; McCarthy, Shaban, Gillespie, & Vick, ; Sakurai et al, ; Scotté et al, , ; Thomas, Williams, Cauchi, Berkovitz, & Smith, ).…”

Section: Resultsmentioning

confidence: 99%

“…The patient sample sizes ranged from 28 to 200, and the final total sample size was 708. Four studies (Hayashi et al, ; Kim et al, ; Matsumoto et al, ; Sakurai et al, ) recruited only patients with breast cancer, whereas the other studies recruited patients with breast cancer as well as those with other cancers (Can et al, ; McCarthy et al, ; Scotté et al, , ; Thomas et al, ). Among the chemotherapy regimens, the patients received taxane alone or in combination with chemotherapy at different doses and cycles in each study.…”

Section: Resultsmentioning

confidence: 99%

“…Among the chemotherapy regimens, the patients received taxane alone or in combination with chemotherapy at different doses and cycles in each study. Most included studies reported at least three chemotherapy cycles (Can et al, ; Hayashi et al, ; Kim et al, ; Matsumoto et al, ; McCarthy et al, ; Sakurai et al, ); however, in the study by Thomas et al, the patients received an average of 4.4 and 5.2 chemotherapy cycles in the plant balm and placebo groups, respectively (Thomas et al, ). Moreover Scotté et al (, ) enrolled patients who had undergone 1–9 chemotherapy cycles.…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies were included in the cryotherapy group; FG, FS and cooling gel pack (CGP) were used in these studies. McCarthy et al (), Hayashi et al ( ) and Matsumoto et al () randomised the patients’ left or right hands to the FG intervention or control, whereas Scotte et al designated the right hand or foot as the cryotherapy intervention side and the left hand or foot as the control side (Hayashi et al, ; Matsumoto et al, ; McCarthy et al, ; Scotté et al, , ). Can et al and Sakurai et al randomised their patients into cryotherapy and control groups (Can et al, ; Sakurai et al, ).…”

Section: Resultsmentioning

confidence: 99%

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Prophylactic management for taxane‐induced nail toxicity: A systematic review and meta‐analysis

et al. 2019

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Objective This meta‐analysis was performed to assess the efficacy of cryotherapy and nail solution (NS) use in preventing nail toxicity (NT) induced by taxane‐based chemotherapy. Methods PubMed, EMBASE, Cochrane Library and ClinicalTrials.gov registry databases were searched for relevant studies published up to December 2018. The primary outcome was taxane‐induced NT. Secondary outcomes were skin toxicity (ST), time to toxicity and patient comfort. Results We reviewed three randomised control trials and six prospective studies with 708 patients. For meta‐analysis, taxane‐induced NT grading was compared. NT and ST were significantly lower in the cryotherapy patients than in the controls (grade 1 NT: risk ratio [RR] = 0.51, 95% confidence interval [CI] = 0.30–0.89; grade 2–3 NT: RR = 0.36, 95% CI = 0.11–1.12; total NT: RR = 0.49; 95% CI = 0.30–0.79; ST: RR = 0.46, 95% CI = 0.33–0.64). The NS‐treated patients exhibited significantly lower NT than the controls. Conclusions Nail solution‐treated or cryotherapy patients exhibited lower NT incidence and severity associated with taxane‐based chemotherapy than the controls. For patients who can afford and comply with NS use or cryotherapy, these measures represent effective prophylactic management for taxane‐induced NT and improve their quality of life and functional statuses. Further studies are needed to establish the routine usage protocols, long‐term efficacy and safety for these interventions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prophylactic management for taxane‐induced nail toxicity: A systematic review and meta‐analysis

et al. 2019

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“…Among non-hematological toxicities, we focused on peripheral neuropathy and watery eyes. Nab-paclitaxel often has non-hematological adverse events, including peripheral neuropathy and muscle pain (11,12). As peripheral neuropathy can lead to dose reduction or complete discontinuation of a treatment, methods of controlling these effects in order to maintain recommended dose levels are critical.…”

Section: Discussionmentioning

confidence: 99%

Phase I Study of Triweekly Nab-Paclitaxel Combined with S-1 in Patients with HER2-negative Metastatic Breast Cancer

Sakaguchi¹,

Nakatsukasa²,

Taguchi³

2016

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Evaluation of Prevention Interventions for Taxane-Induced Dermatologic Adverse Events

2018

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IMPORTANCE Chemotherapy-induced alopecia as well as nail and cutaneous changes occur in up to 89% of patients receiving taxane-based chemotherapy and are associated with cosmetic concerns, psychosocial distress, and overall morbidity.OBJECTIVE To review the efficacy and safety of interventions to prevent taxane-induced dermatologic adverse events.EVIDENCE REVIEW PubMed and Scopus databases were systematically reviewed for studies published in the English language from January 1, 1980, to August 13, 2018. Specific search terms included but were not limited to taxane, docetaxel, paclitaxel, prevent, nail, skin, hair, alopecia, and onycholysis. Primary clinical studies that detailed preventive interventions for taxane-induced dermatologic adverse events and that classified results according to a taxane-specific chemotherapy regimen were reviewed and graded according to a 5-point scale, modified from the Oxford Centre for Evidence-based Medicine.FINDINGS The 34 original reports that met the inclusion criteria consisted of 6 randomized clinical trials, 4 nonrandomized clinical trials, 18 cohort studies, 3 case-control studies, 1 cross-sectional study, and 2 case reports and involved a total of 5647 unique participants. A total of 22 studies addressed preventive interventions for alopecia associated with taxane use, whereas 12 studies focused on taxane-induced skin and nail changes. Specifically, 20 (95%) of 21 studies supported the use of either a cold cap or a scalp cooling system to reduce alopecia but reported substantial differences in efficacy depending on the chemotherapy regimen. Scalp cooling was generally considered safe by all pertinent studies despite a single report of scalp skin metastasis. Similarly, use of frozen gloves and frozen socks in the prevention of nail and cutaneous hand and foot toxic effects was considered safe in 7 (88%) of 8 studies, although discomfort was common and frostbite was noted in 1 patient. Overall, use of frozen gloves was endorsed by 4 (67%) of 6 studies to prevent nail toxic effects and by 3 (60%) of 5 studies to prevent cutaneous hand changes.CONCLUSIONS AND RELEVANCE Scalp hypothermia with cold caps or scalp cooling systems has demonstrated efficacy as a monotherapy in preventing taxane-induced alopecia, and use of frozen gloves and socks has been associated with reduced nail and skin changes. Future studies should establish the routine usage protocols, standard outcome measures, and long-term efficacy and safety for these interventions.

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Cryotherapy for docetaxel-induced hand and nail toxicity: randomised control trial

Abstract: While cryotherapy in the form of frozen gloves for the cutaneous toxicities associated with docetaxel is safe, its limited efficacy, patient discomfort and some logistical issues preclude its use in our clinical setting.

Cited by 29 publications

References 17 publications

Prophylactic management for taxane‐induced nail toxicity: A systematic review and meta‐analysis

Prophylactic management for taxane‐induced nail toxicity: A systematic review and meta‐analysis

Phase I Study of Triweekly Nab-Paclitaxel Combined with S-1 in Patients with HER2-negative Metastatic Breast Cancer

Evaluation of Prevention Interventions for Taxane-Induced Dermatologic Adverse Events

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