Cryotherapy for Breast Fibroadenomas

Littrup, Peter J.; Freeman-Gibb, Laurie; Andea, Aleodor A.; White, Michael; Amerikia, Kathy Carolin; Bouwman, David L.; Harb, Ted; Sakr, Wael

doi:10.1148/radiol.2341030931

Cited by 120 publications

(82 citation statements)

References 23 publications

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“…Littrup et al (9) reported that 42 biopsy-confirmed fibroadenomas in 29 patients who underwent percutaneous cryoablation. All patients were very comfortable with the resolution of palpable mass effect and cosmetic results.…”

Section: Clinical Resultsmentioning

confidence: 99%

“…Compared with the above techniques, ultrasound-guided cryoablation of fibroadenomas has been shown to be a costeffective alternative with a low morbidity risk (7)(8)(9)15,19). A number of potential advantages include: v Cryoablation for tumor destruction is well suited for ultrasound guidance and monitoring because the hyperechoic effect obtained with ice-ball formation can be easily identified and therapy can be directed with precision; v This technique is a mini-invasive and virtually painless procedure, can be performed under local anesthesia in an office-based breast clinic; v There is an excellent cosmesis without tissue removal and minimal scarring.…”

Section: Discussionmentioning

confidence: 99%

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Cryosurgery for Breast Fibroadenomas

Niu¹,

Wu²,

Xu³

2012

Modern Cryosurgery for Cancer

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Fibroadenomas are the most common benign tumors in the breast of women during their second and third decades of life, and account for 30% and 50% of all breast biopsies, and these rates rise to about 75% for biopsies in women under the age of 20. The tumors commonly present a painless, palpable, solid, rubbery, well-circumscribed, and movable mass with no associated risk of carcinoma. With the vast array of image-guided biopsy devices, fibroadenomas can be easily sampled and diagnosed. With use of ultrasoundguided cryoablation for breast fibroadenomas, there is little or no pain, targeted lesions are reduced in size or eliminated, scarring is minimal, cosmesis is outstanding, and patient satisfaction is excellent. Cryosurgery should be a preferred option for those patients desiring definitive therapy for their fibroadenomas without surgical intervention.

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Section: Clinical Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cryosurgery for Breast Fibroadenomas

Niu¹,

Wu²,

Xu³

2012

Modern Cryosurgery for Cancer

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“…9 Others have shown that cryoablation is highly successful in treating fibroadenomas and other benign breast lesions. [10][11][12][13][14][15] In 2001, the Visica™ system for cryoablation of fibroadenomas was approved by the US Food and Drug Administration (FDA). 16,17 Cryoassisted lumpectomy is another application of this technique for the localization and removal of non-palpable breast lesions.…”

Section: R Y O a B L A T I O N To D A Ymentioning

confidence: 99%

“…22 An injection of saline may be used to increase the distance between the tumor and skin where the two are too close, avoiding hypothermiainduced skin damage. 15 The treated area is left in place to be absorbed by the host inflammatory response.…”

Section: R Y O a B L A T I V E Te C H N I Q U Ementioning

confidence: 99%

“…While the freezing procedure itself generates anesthesia to the breast tissue 29 it allows the procedure to be an office-based modality. 10,15 Cryoablation-induced anesthesia differs from heat-based tissue destruction in that the latter causes enough discomfort to require general anesthesia or significant IV sedation to be provided in an operating room (OR). The need for narcotics for post-operative pain is minimal.…”

Section: T H E a D V A N T A G E S A N D D I S A D V A N T A G E S O mentioning

confidence: 99%

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Cryoablation of Early-stage Breast Cancer

Chang¹,

Prati²

2006

Oncology &Amp; Hematology Review (US)

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Thermocouples

Wren

Loyd

2006

Encyclopedia of Medical Devices and Instrumentation

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Thermocouples are widely used in various applications in medicine and biomedical engineering. The sensors are accurate, flexible, well documented, and not too expensive. Thus they are considered to have the best cost/performance ratio for many applications. Thermocouples are based on the thermoelectric Seebeck effect, which gives an electric potential between the junctions of two dissimilar metallic conductors when the junctions are held at different temperatures. Virtually every pair of metallic conductors are possible to use, but for practical reasons standardized thermocouples with determined thermoelectric properties and temperature/potential relation are used. As all temperature sensor thermocouples are associated with various kinds of measurement errors. Some are specific for thermocouples, but the most important is based on the fact that every contact sensor only measures its own temperature. The sensor should therefore be in good thermal contact with the measuring object in order to obtain an accurate temperature at a reasonable time. Depending on, for example, the present temperature gradients and the heat flux in the probe compared to its surroundings, significant and even substantial deviations and uncertainties can easily occur. Another important source of measurement errors is electromagnetic (EM) interference, which is particular troublesome in EM induced thermal treatment applications when temperature measurement is carried out in strong fields.

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Cryotherapy for Breast Fibroadenomas

Abstract: Cryotherapy of fibroadenomas is a safe, effective, and virtually painless clinic-based (ie, outpatient) treatment option with good cosmesis.

Cited by 120 publications

References 23 publications

Cryosurgery for Breast Fibroadenomas

Cryosurgery for Breast Fibroadenomas

Cryoablation of Early-stage Breast Cancer

Thermocouples

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