Cryotherapy

Grant, Chantal Spencer; Vicencio, Alfin G.

doi:10.1007/978-3-030-54924-4_41

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…This leads to the disruption of cell organelles and fluid shifts in dehydrated cells. The very low temperatures can also cause local vasoconstriction and thrombosis [9].…”

Section: Discussionmentioning

confidence: 99%

Cryoprobe for Endoscopic Enucleation in Children with Pulmonary Tuberculosis: Effective but Not Without Danger – Case Report and Review of Literature

Goussard,

Eber,

Venkatakrishna

et al. 2024

Respiration

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Introduction: Tuberculosis (TB) in children under 15 years often results in airway compression, with bronchus intermedius (BI) being the most common site. Endoscopic enucleations can be used to remove lymph nodes and establish an airway in severe cases. Both rigid and flexible bronchoscopy are suitable, with alligator forceps being preferred for its ability to extract tissue. Recent studies have also explored cryoprobe enucleation. Case Presentation: An HIV-positive boy with persistent symptoms after 9 months of TB treatment was diagnosed based on his mother’s and sister's Xpert MTB/RIF positive status. He was started on 4-drug TB treatment, but the child remained clinically symptomatic with abnormal chest X-ray and unconfirmed TB. Bronchoscopy was performed, revealing complete obstruction of BI due to caseating granulomas causing collapse of the right middle and lower lobes. Cryotherapy was used to recanalise the airway, and follow-up bronchoscopy confirmed patent BI. Conclusion: While cryotherapy was effective in the restoration of airway patency in this case, there is a lack of knowledge about its use in children.

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“…This leads to the disruption of cell organelles and fluid shifts in dehydrated cells. The very low temperatures can also cause local vasoconstriction and thrombosis [9].…”

Section: Discussionmentioning

confidence: 99%

Cryoprobe for Endoscopic Enucleation in Children with Pulmonary Tuberculosis: Effective but Not Without Danger – Case Report and Review of Literature

Goussard,

Eber,

Venkatakrishna

et al. 2024

Respiration

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“…[ 2 ] Several cryotherapeutic techniques are available, which work based on the Joule–Thomson effect, to freeze tissues to extremely low temperatures for destruction (cryoablation), adhesion (cryo-adhesion) or biopsy (cryobiopsy). [ 3 ]…”

Section: Introductionmentioning

confidence: 99%

Safety, utility and clinical efficacy of cryobiopsy of lung in paediatric population—A single centre experience

Chandra,

Srikanta,

Madhusudan

et al. 2023

Lung India

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Background: Surgical lung biopsy (SLB) or video-assisted thoracic surgery (VATS) has been the traditional gold standard modality for diagnosing paediatric interstitial lung diseases. Cryobiopsy of the lung has recently been shown to be a novel technique with very good sensitivity and specificity in the diagnosis of various interstitial lung disorders in adults. Although there are a few case reports of the same in children, pediatric cryo lung biopsies are rarely performed due to the lack of the necessary equipment and the lack of expertise. Methods: A retrospective single-centre study was conducted with twelve consecutive children with diffuse parenchymal lung disease diagnosed both clinically and on high-resolution computed tomography (HRCT) of the chest which were included in the study between October 2020 and September 2022 to measure the diagnostic yield and safety of the procedure. The site from where cryobiopsy was to be done was chosen after a multidisciplinary meeting with the paediatric radiologist. Results: Twelve children (eight males and four females) were included in the study who underwent a cryobiopsy in the duration of two years. The mean age of the cases involved was 8 years and 3 months. With the youngest and oldest being 12 days and 15 years, respectively, all children underwent cryobiopsy as mentioned above. Diagnostic yield was achieved in 92% of cases. Conclusion: Cryobiopsy is a valuable diagnostic tool in childhood interstitial lung diseases, which offers a less invasive option for obtaining lung tissue samples with a better yield which can aid in accurate diagnosis, a good safety profile and a shorter hospital stay. Our study emphasizes that in trained centres, TBCB is a safe, effective and less invasive way to obtain tissue diagnosis in children with ChILD.

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“…The formation of ice‐crystals disrupts cell organelles and fluid shifts dehydrate cells. Additionally, the low temperatures lead to local vasoconstriction and thrombosis 2 …”

Section: Introductionmentioning

confidence: 99%

Cryotherapy in the paediatric airway: Indications, success and safety

et al. 2022

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Background and objective Cryotherapy in interventional bronchoscopy is a new treatment modality, which has recently been made available for the paediatric airway. Lack of experience and safety concerns have led to hesitant adaptation. The aim of this study was to assess indications, success rates and complications of airway cryotherapy in children. Methods Bronchoscopists from medical centre performing cryotherapy in patients between 0 and 18 years were invited to participate in a prospective study based on an online questionnaire. Patient and participant data were collected between June 2020 and June 2021. Results A total of 69 cryotherapy procedures were performed in 57 patients a for three main indications: Biopsy (30), restoration of airway patency (23) and foreign body aspiration (16). The overall success rate was 93%, the remaining 7% were performed for foreign body removal and required a switch of technique. Restoration of airway patency was successfully applied in various pathologies, including mucus plugs, bronchial casts and post traumatic stenosis. The diagnostic yield of transbronchial biopsies was 96%. No severe complications were encountered; one pneumothorax following a cryobiopsy required a chest drain for 48 h. No child was admitted to intensive care or died from a procedural complication. Conclusion In this largest paediatric case collection to date, cryotherapy was safe and carried a high success rate. Cryobiopsy compares favourably to the widely used forceps biopsy and could replace it in the future. Paediatric bronchoscopists are encouraged to add cryotherapy to their armamentarium of airway interventions.

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Cryotherapy

Cited by 3 publications

References 6 publications

Cryoprobe for Endoscopic Enucleation in Children with Pulmonary Tuberculosis: Effective but Not Without Danger – Case Report and Review of Literature

Cryoprobe for Endoscopic Enucleation in Children with Pulmonary Tuberculosis: Effective but Not Without Danger – Case Report and Review of Literature

Safety, utility and clinical efficacy of cryobiopsy of lung in paediatric population—A single centre experience

Cryotherapy in the paediatric airway: Indications, success and safety

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