Cryosurgical treatment of premalignant disease of the uterine cervix

Systematic reviews and meta-analyses of benefits and harms of cryotherapy, LEEP, and cold knife conization to treat cervical intraepithelial neoplasia

“…The present systematic review of the literature was conducted to inform decision making about effective and safe treatments for CIN 2-3. Unfortunately, although not unexpectedly, only a few small RCTs were found 1 non-randomized study of 134 women reported no difference in time to conceive at ≥3 years when compared with no treatment [15] 1 nonrandomized study found no difference in time to conceive in 36 women ≤24 months [16]; another found no infertility ≤12 months in 166 women [17] Spontaneous abortions 7 nonrandomized studies reported 12 spontaneous abortions in 210 pregnancies with a range of 0%-15% (follow-up 6 months to 10 years) [11][12][13][14][18][19][20] 3 nonrandomized studies of 207 women reported 12 spontaneous abortions [21][22][23] 3 nonrandomized studies found 10 spontaneous abortions in 1090 women [22][23][24] Abbreviations: LEEP, loop electrosurgical excision procedure; CKC, cold knife conization.…”

Results of CO2 laser cylinder vaporization of cervical intraepithelial disease in 1234 patients. An analysis of failures

“…The past decade has seen an acceptance of colposcopy as an important adjunct to diagnosis, and allied to it the development of cryosurgery, electrodiathermy. cold coagulation and later COL laser ablation (Crisp 1972;Davis et ul. 1972;Gray & Christopherson 1975;Richart et al 1980;Mylotte & Jordan 1981).…”

The treatment of cervical intraepithelial neoplasia using the carbon dioxide laser

“…In our department there are increasing numbers of young women with such lesions, so that conization with possible complications including infection, cervical stenosis or incompetence (Davis et al 1972;Jones et al 1979) becomes less acceptable. Colposcopy and directed biopsy has been shown to be accurate (Kohan et al 1977;Gray & Christopherson 1975) and enables conservative treatment methods such as cryosurgery, electrodiathermy and CO, laser to be undertaken (Crisp 1972;Ortiz et al 1973). The principle of the CO, laser is that of a high-energy coherent light source which, under directional control, evaporates intracellular water and disrupts cells and tissues (Bellina 1977;Baggish 1980;Wright & Davies 1981).…”