Cryosurgery of Cutaneous Malignancies

Crutcher, William A.

doi:10.1007/978-1-4612-3790-7_21

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…After inclusion criteria were applied, the full text of 310 articles were assessed. Of these, 129 studies were included in final analysis (Figure 1). Study characteristics, including risk of bias, are described in eTable 1 in the Supplement.…”

Section: Resultsmentioning

confidence: 99%

“…Of these, 87 studies with 122 484 tumors were included in the random effects analysis risk ratio, and 62 studies with 116 958 tumors were included in analysis of incidence data. Treatment modality was assessed by 28 studies with 10 967 patients and 6118 cSCC tumors.…”

Section: Resultsmentioning

confidence: 99%

“…87 studies 8, 10, 11, 13-19, 21, 23, 25, 27, 30, 31, 33-35, 37-41, 43-45, 47, 48, 50, 52, 53,55-64,66,69-75,77-81,83-88,90-94,96-98,100-102,104,106-115,118-121 with 122 484 tumors were included in the random effects analysis risk ratio, and 62 studies 7, 8, 10, 12, 13, 15, 17-20, 22, 23, 25-32, 36-38, 40, 42, 46-48, 50, 53-56, 59, 63, 65, 67, 68, 70, 71, 73, 74, 76, 79-85, 89, 90, 92-95, 98, 99, 101, 103, 114, 116 with 116 958 tumors were included in analysis of incidence data. Treatment modality was assessed by 28 studies 8,10,27,34,35,40,41,53,59,80,90,96,97,101,[122][123][124][125][126][127][128][129][130][131][132][133][134][135] with 10 967 patients and 6118 cSCC tumors.…”

Section: Meaningmentioning

confidence: 99%

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Association of Patient Risk Factors, Tumor Characteristics, and Treatment Modality With Poor Outcomes in Primary Cutaneous Squamous Cell Carcinoma

et al. 2023

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ImportancePrimary cutaneous squamous cell carcinoma is usually curable; however, a subset of patients develops poor outcomes, including local recurrence, nodal metastasis, distant metastasis, and disease-specific death.ObjectivesTo evaluate all evidence-based reports of patient risk factors and tumor characteristics associated with poor outcomes in primary cutaneous squamous cell carcinoma and to identify treatment modalities that minimize poor outcomes.Data SourcesPubMed, Embase, and SCOPUS databases were searched for studies of the topic in humans, published in the English language, from database inception through February 8, 2022.Study SelectionTwo authors independently screened the identified articles and included those that were original research with a sample size of 10 patients or more and that assessed risk factors and/or treatment modalities associated with poor outcomes among patients with primary cutaneous squamous cell carcinoma.Data Extraction and SynthesisData extraction was performed by a single author, per international guidelines. The search terms, study objectives, and protocol methods were defined before study initiation. A total of 310 studies were included for full-text assessment. Owing to heterogeneity of the included studies, a random-effects model was used. Data analyses were performed from May 25 to September 15, 2022.Main Outcomes and MeasuresFor studies of risk factors, risk ratios and incidence proportions; and for treatment studies, incidence proportions.ResultsIn all, 129 studies and a total of 137 449 patients with primary cutaneous squamous cell carcinoma and 126 553 tumors were included in the meta-analysis. Several patient risk factors and tumor characteristics were associated with local recurrence, nodal metastasis, distant metastasis, disease-specific death, and all-cause death were identified. Among all factors reported by more than 1 study, the highest risks for local recurrence and disease-specific death were associated with tumor invasion beyond subcutaneous fat (risk ratio, 9.1 [95% CI, 2.8-29.2] and 10.4 [95% CI, 3.0- 36.3], respectively), and the highest risk of any metastasis was associated with perineural invasion (risk ratio, 5.0; 95% CI, 2.3-11.1). Patients who received Mohs micrographic surgery had the lowest incidence of nearly all poor outcomes; however, in some results, the 95% CIs overlapped with those of other treatment modalities.Conclusions and RelevanceThis meta-analysis identified the prognostic value of several risk factors and the effectiveness of the available treatment modalities. These findings carry important implications for the prognostication, workup, treatment, and follow-up of patients with primary cutaneous squamous cell carcinoma.Trial RegistrationPROSPERO Identifier: CRD42022311250

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%