Cryostorage duration does not affect pregnancy and neonatal outcomes: a retrospective single-centre cohort study of vitrified–warmed blastocysts

Ueno, Satoshi; Uchiyama, Kazuo; Kuroda, Tomoko; Yabuuchi, Akiko; Ezoe, Kenji; Okimura, Tadashi; Okuno, Takashi; Kobayashi, Tamotsu; Kato, Keiichi

doi:10.1016/j.rbmo.2018.03.008

Cited by 36 publications

(30 citation statements)

References 24 publications

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“…37 A single-center study conducted in Japan, including more than 8,700 cycles, demonstrated that cryostorage of vitrified blastocysts in open devices (Cryotop) up to 8 years did not impact clinical and neonatal outcomes following single vitrified/warmed blastocyst transfer. 38 Similar conclusions were reached in the study of Wirleitner et al, 39 which included 603 single and double blastocyst transfers and 1,077 blastocysts vitrified in an "aseptic" closed device (Vitrisafe). The results showed that storage time of up to 6 years following vitrification did not have a negative impact on blastocyst survival and implantation, or congenital malformation rates in resulting newborns.…”

Section: Reduced or Lost Viability: (I) Duration Of Storagesupporting

confidence: 61%

Human Reproductive Cell Cryopreservation, Storage, Handling, and Transport: Risks and Risk Management

Alikani

Parmegiani

2018

Semin Reprod Med

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Millions of human oocytes and embryos are stored in thousands of locations across the globe. This inventory continues to grow as cryopreservation becomes more successful and more widely applied. The results of studies assessing pregnancy and neonatal outcomes following frozen embryo transfer (FET) have been encouraging, showing lower incidences of small for gestational age neonates and preterm birth compared with fresh transfers. However, many of these studies have also shown that the odds of large for gestational age births and macrosomia are higher after FET. The origin of these conditions remains unclear. Cryostorage presents many potential risks to the cryopreserved cells/tissues, including loss of viability and contamination, but risks are faced also by care providers—for example, injury and financial liability—and by patients—for example, accidental loss of their reproductive tissues, the burden of embryos they no longer wish to use and failing to meet their contractual obligations. Studies are urgently needed to explore and understand all dimensions of cryostorage to help ART clinics develop effective strategies to manage associated risks. The future of cryostorage, as for many other areas of ART and medicine, is automation.

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Section: Reduced or Lost Viability: (I) Duration Of Storagesupporting

confidence: 61%

Human Reproductive Cell Cryopreservation, Storage, Handling, and Transport: Risks and Risk Management

Alikani

Parmegiani

2018

Semin Reprod Med

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Section: Risk Of Reduced or Lost Viabilitymentioning

confidence: 96%

“…Limited safety data exist on vitrified oocytes stored up to 3.5 years (Goldman et al, 2015). In a recent issue of RBMO, a large clinical study from the Kato Ladies Clinic in Japan (Ueno et al, 2018) demonstrated that duration of cryostorage of vitrified human embryos did not impact clinical and neonatal outcomes. The study compared three groups with 0-97 months of cryostorage and found no significant differences in live birth rates, birth weight or congenital malformation rates among these groups.…”

Section: Risk Of Reduced or Lost Viabilitymentioning

confidence: 99%

Cryostorage of human gametes and embryos: a reckoning

Alikani¹

2018

Reproductive BioMedicine Online

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“…56 However, this is contradicted by human clinical data using such systems. 57 Nevertheless, current data suggest that even with these more "exposed" storage systems, the most extreme clinical long-term storage period that could be reasonably envisioned should be safe in terms of radiation exposure. Future embryologists storing frozen embryos for multigenerational space flight may need to pursue further research in this area.…”

Section: Storage Duration and Potential Consequencesmentioning

confidence: 97%

Life Interrupted: The Nature and Consequences of Cryostasis

Malter

2018

Semin Reprod Med

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Cryopreservation and associated cryostorage has become a well-established technique in both basic and clinical science. When the potentially lethal consequences of freezing itself are ameliorated, existence at cryogenic temperatures seems to be a form of true viable stasis that can persist for long periods of time. Natural cryopreservation and revival after long-term periods in cryostasis is reality in many species. While some evidence exists for imperfections in artificial cryopreservation protocols and storage, these protocols are for the most part successful and compatible with efficient restoration of vitality in a variety of biomaterial after freezing. Clinical protocols in use for cryopreserving and storing gametes and embryos in human-assisted reproduction are similarly well proven and supported by a large body of basic science and clinical outcome data.

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Cryostorage duration does not affect pregnancy and neonatal outcomes: a retrospective single-centre cohort study of vitrified–warmed blastocysts

Cited by 36 publications

References 24 publications

Human Reproductive Cell Cryopreservation, Storage, Handling, and Transport: Risks and Risk Management

Human Reproductive Cell Cryopreservation, Storage, Handling, and Transport: Risks and Risk Management

Cryostorage of human gametes and embryos: a reckoning

Life Interrupted: The Nature and Consequences of Cryostasis

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