Cryopreserved venous allograft is an acceptable conduit in patients with current or prior angioaccess graft infection

Harlander-Locke, Michael P.; Lawrence, Peter F.; Ali, Aamna; Bae, Esther; Kohn, James; Abularrage, Christopher J.; Ricci, Michael A.; Lemmon, Gary W.; Peralta, Sotero; Hsu, Jeffrey H.

doi:10.1016/j.jvs.2017.03.450

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…23 In a large cohort study of 457 patients, it was observed that cryopreserved vein graft had a better one-year primary patency rate (58%) versus cryopreserved arterial graft (48%) when used as haemodialysis access. 24 These grafts can be needled as early as two weeks after implantation. 25 Furthermore, cryopreserved vein allografts have been reported with a very low infection rate when compared with synthetic vascular graft.…”

Section: Discussionmentioning

confidence: 99%

Investigation of a method for long-term preservation of the vascular allograft

Musk

et al. 2021

Vascular

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Background/objective During multiple organ procurement, blood vessels are routinely retrieved and stored in University of Wisconsin solution and then discarded after two weeks, if not used at organ transplantation owing to lack of a method for long-term preservation. Therefore, the aim of this study is to investigate a method for long-term preservation of vascular allografts in ethanol. Methods Aorta and vena cava allografts were retrieved and stored in 75% ethanol solution for 12 months at 4°C. Four pigs were divided into two groups. A segment of aorta was excised and replaced by insertion of preserved aorta graft (Group A) or vena cava graft (Group V). The pigs were observed for six weeks. A laparotomy was performed and the vascular graft was harvested for histopathology followed by euthanasia at the end of study. Results Three pigs recovered uneventfully, while one pig died from venous graft rupture in the third week after surgery. There was no aneurysmal formation or thrombosis in the grafts. Some calcification was seen over aorta allograft. On histopathology, the elastic pattern was almost normal, although the endothelial cells degenerated after preservation. After implantation, the formation of the endothelium cell-like layer was seen in both aorta and vena cava allografts. Conclusion Vascular allografts were functional after preservation for 12 months. The vena cava grafts had much less wall calcification than the aorta grafts. Further studies are necessary to investigate vascular graft remodelling with a longer observation period after implantation.

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Section: Discussionmentioning

confidence: 99%

Investigation of a method for long-term preservation of the vascular allograft

Musk

et al. 2021

Vascular

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“…Regarding "Data, guidelines, and practice of revascularization for claudication" Peripheral vascular disease is an ongoing pandemic with increased prevalence secondary to increase of an elderly population. 1 It constitutes >45% of total vascular interventions performed by vascular interventionists. 2 There are myriad vascular interventions offered to patients with peripheral vascular disease.…”

Section: Replymentioning

confidence: 99%

“…In this multicenter registry-based study, Harlander-Locke et al 1 reported interesting results of a large cohort of patients who underwent placement of a cryopreserved allograft for prior or current infection of their hemodialysis access. They concluded that cryopreserved vessels, in particular cryopreserved veins, are an acceptable replacement conduit in these patients.…”

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confidence: 99%