Cryopreserved Ultra-Thick Human Amniotic Membrane for Conjunctival Surface Reconstruction After Excision of Conjunctival Tumors

Tanaka, Thaís Shiota; Demirci, Hakan

doi:10.1097/ico.0000000000000737

Cited by 16 publications

(12 citation statements)

References 19 publications

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“…[17, 96] The most commonly used graft is amniotic membrane, available in freeze or air-dried and cryopreserved forms and in various thicknesses. [132]…”

Section: Treatmentmentioning

confidence: 99%

Advances in the management of conjunctival melanoma

Vora

Demirci

Marr

et al. 2017

Survey of Ophthalmology

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“…[17, 96] The most commonly used graft is amniotic membrane, available in freeze or air-dried and cryopreserved forms and in various thicknesses. [132]…”

Section: Treatmentmentioning

confidence: 99%

Advances in the management of conjunctival melanoma

Vora

Demirci

Marr

et al. 2017

Survey of Ophthalmology

Self Cite

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“…However, for large and diffuse lesions without clear margins, even intended excisional biopsy may not remove the entire lesion. Also, for large or recurrent lesions, excisional biopsies lead to increased risks of limbal stem cell deficiency, symblepharon, and scarring 10,11 . Lastly, as medical options for treatment of OSSN increase in number and become more utilized, non-invasive methods of diagnosis become more important 12 .…”

Section: Ocular Surface Squamous Neoplasiamentioning

confidence: 99%

Updates in Ocular Surface Tumor Diagnostics

Nanji¹,

Mercado²,

Dubovy³

et al. 2017

International Ophthalmology Clinics

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Purpose To evaluate technologies and techniques available for the diagnosis of ocular surface tumors. Methods A review of the literature from 1947 to 2017, through the PubMed Database, was conducted in order to evaluate current diagnostic methods for ocular surface tumors. Results Ocular surface squamous neoplasia, conjunctival melanoma, and conjunctival lymphoma are the three most common ocular surface malignancies. Technologies available to assist with diagnosis of these conditions, in addition to full thickness biopsy, include vital dyes, aspiration and impression cytology, in vivo confocal microscopy, ultrasound biomicroscopy, genetic testing, and anterior segment optical coherence tomography. Conclusions Histology remains the gold standard for diagnosis for all 3 of these malignancies. However, multiple diagnostic techniques are available to assist in making preliminary and early diagnoses, in differentiating between similar-appearing lesions, and in some cases, avoiding biopsy prior to initiating treatment. As imaging and technology continue to evolve, these adjunctive techniques will likely continue to play a greater role in clinical practice.

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“…Similar to AM, cryopreserved UCP also exerts therapeutic actions [18]. It is easier to handle [19] and has already been successfully used for the glaucoma shunt tubes covering [20] and conjunctival surface reconstruction [19]. …”

Section: Introductionmentioning

confidence: 99%

Umbilical Cord Patch Transplantation for Corneal Perforations and Descemetoceles

Xie

Zhao

Liu

et al. 2017

Journal of Ophthalmology

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Purpose To evaluate the clinical outcome of umbilical cord patch (UCP) transplantation for deep corneal ulcers with perforations and descemetoceles. Methods In this retrospective, noncomparative, interventional case series, 11 eyes of 11 patients with corneal perforation or descemetocele were included. The thickness and microstructure of UCP were measured. All eyes were treated with UCP and amniotic membrane transplantation for corneal reconstruction. Corneal ulcer healing, corneal thickness, anterior chamber formation, and best-corrected visual acuity (BCVA) were recorded and analyzed. Results The thickness of human UCP is 398.6 ± 102.8 μm (n = 5) with compact aligned fibers. The average age was 56.2 ± 15.8 (ranging from 22 to 75) years. The mean follow-up period was 7.1 ± 1.7 (ranging from 5 to 10) months. Four patients had descemetocele and 7 had perforation. The anterior chambers in all the 7 perforated corneas were formed at postoperative day 1. All patients regained a normal corneal thickness and smooth corneal surface within the first postoperative month. The vision improved in 10 eyes and remained unchanged in 1 eye. No recurrence nor side effects occurred during the follow-up. Conclusions UCP can serve as an alternative material in the treatment of corneal perforations and descemetoceles. This treatment option is also beneficial in those countries with limited cornea donors and eye bank services.

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Cryopreserved Ultra-Thick Human Amniotic Membrane for Conjunctival Surface Reconstruction After Excision of Conjunctival Tumors

Abstract: Cryopreserved ultra-thick human AM is a well-tolerated, effective graft material that is easy to handle. It is a viable alternative for conjunctival surface reconstruction after excision of a conjunctival tumor.

Cited by 16 publications

References 19 publications

Advances in the management of conjunctival melanoma

Advances in the management of conjunctival melanoma

Updates in Ocular Surface Tumor Diagnostics

Umbilical Cord Patch Transplantation for Corneal Perforations and Descemetoceles

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