Cryopreservation and IVF in the time of Covid-19: what is the best good tissue practice (GTP)?

Pomeroy, Kimball O.; Schiewe, M.C.

doi:10.1007/s10815-020-01904-5

Cited by 26 publications

(30 citation statements)

References 26 publications

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“…Some embryologists have advocated placing all new cryopreserved specimens into a quarantine tank until patients are determined to have negative viral test results at some future time, especially when dealing with donor semen. Furthermore, all gametes and embryos should go through extensive washing to dilute out potential viral contamination to reduce the possibility of contamination with SARS-CoV-2 [ 86 , 87 ]. The use of high-security straws may also minimize the risks associated with cryopreserving sperm during the pandemic.…”

Section: Sars-cov-2 and Male Fertilitymentioning

confidence: 99%

Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

et al. 2021

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Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to cause pneumonia-like complications in the respiratory system. Organ-to-organ transmission has not been ruled out, thereby raising the possibility of the impact of SARS-CoV-2 infection on multiple organ systems. The male reproductive system has been hypothesized to be a potential target of SARS-CoV-2 infection, which is supported by some preliminary evidence. This may pose a global threat to male fertility potential, as men are more prone to SARS-CoV-2 infection than women, especially those of reproductive age. Preliminary reports have also indicated the possibility of sexual transmission of SARS-CoV-2. It may cause severe complications in infected couples. This review focuses on the pathophysiology of potential SARS-CoV-2 infection in the reproductive organs of males along with their invasion mechanisms. The risks of COVID-19 on male fertility as well as the differences in vulnerability to SARS-CoV-2 infection compared with females have also been highlighted.

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Section: Sars-cov-2 and Male Fertilitymentioning

confidence: 99%

Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

et al. 2021

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“…Scientists have quickly related to good tissue practices in vitro fertilization and a rethink is on about encouraging biopsies and focusing on safe vitrification protocols keeping in mind that ova, sperm, and embryos could be possible vectors for disease transmission with the limited research on the SARS-CoV-2 virus. Over the last decade, improvements in cryosurvival and improved live birth rates have been associated with zona pellucida breaching protocols such as blastocyst collapsing and Day 5 biopsies [ 23 ]. In contemporary IVF lab practice, embryos are no longer protected by an intact zona pellucida when vitrified and in cryostorage.…”

Section: Discussionmentioning

confidence: 99%

Will Procreation Ever Be The Same After COVID-19?

Allahbadia

2021

J Obstet Gynecol India

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Medically assisted procreation will never be the same again after this China Virus epidemic. With billions of lives being affected by this damaging global pandemic, medically assisted procreation services were not left unharmed with far-reaching consequences. New challenges are now emerging concerning COVID-19, such as associated reproductive implications and the consequences of assisted and natural procreation in the presence of acute SARS-CoV-2 infection and delayed consequences after patient recovery. There is a hypothesis that testicular damage and subsequent infertility may result following COVID-19 infection and the possibility of sexual transmission, as SARS-CoV-2 has been identified in the semen of infected patients. Vaccine hesitancy in young women planning pregnancies has been heightened because of the spread of misinformation on social media stating that COVID-19 vaccines will cause sterility in women. Reassuring data from accidental pregnancies that have occurred in the clinical trials of approved COVID-19 vaccines indicate that vaccination does not harm fertility or increase the rate of miscarriage. Scientists have quickly related to good tissue practices in vitro fertilization and a rethink is on about encouraging biopsies and focusing on safe vitrification protocols keeping in mind that ova, sperm, and embryos could be possible vectors for disease transmission with the limited research on the SARS-CoV-2 virus. Going ahead with segmented IVF without delay, freezing the generated embryos and pushing back the embryo transfer after the pandemic appears to be the best strategy at present. An international group of researchers have proposed a prognostic stratification of more vulnerable infertility cases in order to plan a progressive restart of worldwide fertility treatments.

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“…Albeit small in number, there is definitive evidence of placental infection and vertical transmission of SARS-CoV-2 [51-55]. While there is no evidence to suggest that the ART pregnancies are additionally susceptible or protected from the ill effects of COVID-19, the possibility of vertical transmission from an IVF clinic may be negligible [57]. It is important that the couples are informed of the current evidence of COVID-19 on pregnancy prior to opting for ART.…”

Section: Discussionmentioning

confidence: 99%

Resuming assisted reproduction services during COVID-19 Pandemic: An Indian experience

Jirge¹,

Patwardhan²,

Paranjape³

et al. 2020

Preprint

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Purpose: The pandemic of COVID-19 has affected many countries and medical services including assisted reproductive treatment (ART) have been hampered. The purpose of the study was to assess the preparedness of ART clinics and staff to resume services and patients reasons to initiate treatment and key performance indicators (KPIs) of ART labs during pandemic. Methods: Semi-descriptive report of two private in-vitro fertilization (IVF) clinics in Maharashtra, India, when COVID-19 testing for asymptomatic people was unavailable. Time required for replenishing laboratory supplies, and staff preparedness to function under new norms of pandemic was documented. Infection mitigation measures at workplace and triaging strategy were evaluated. KPIs of the clinics were evaluated. Results: One-third of the patients consulted through telemedicine accepted or were eligible to initiate treatment upon clinic resumption. Lack of safe transport and financial constraints prevented majority from undergoing IVF, and only 9 percent delayed treatment due to fear of pandemic. With adequate training, staff compliance to meet new demands could be achieved within a week, but supply of consumables was a major constraint. 52 cycles of IVF were performed including fresh cycles and frozen embryo transfers with satisfactory KPIs even during pandemic. Conscious sedation and analgesia during oocyte retrieval was associated with reduced procedure time and no intervention for airway maintenance, compared to general anaesthesia. Self reported pain scores by patients ranged from nil to mild on a graphic rating scale. Conclusion: This study provides a practical insight and will aid in forming guidelines for resumption of IVF services during pandemic.

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Cryopreservation and IVF in the time of Covid-19: what is the best good tissue practice (GTP)?

Cited by 26 publications

References 26 publications

Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

Will Procreation Ever Be The Same After COVID-19?

Resuming assisted reproduction services during COVID-19 Pandemic: An Indian experience

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