Cryoplasty for Canine Iliac Artery Stenosis and its Impact on Expression of TIMP-2 and MMP-2

Wu, Zhengzhong; Zang, Shengbing; liu, Wenwen; Jiang, Na; Weizhu, Yang

doi:10.1177/1538574415603488

Cited by 2 publications

(4 citation statements)

References 26 publications

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“…Interestingly, we observed the lowest TIMP activity in the ITA, moderate in the SV, and the highest in the RA cross-sections. A previous study describing the effects of antiproliferative strategies reported a higher TIMP expression in successfully treated vessels [18]. Thus, the stronger immunostaining for TIMPs in the RA wall cells than in the SV sections observed in our study seems to have positive implications.…”

Section: Gelatinase Expression In Aortocoronary Graft Wallssupporting

confidence: 68%

“…This leads to neointima formation that precedes the development of atherosclerosis. These pathological processes are observed both in damaged arterial walls (for example, after angioplasty for stenosis treatment) and in venous grafts implanted into arterial circulation [12,18]. This leads to complete occlusion and clinical disease recurrence.…”

Section: Gelatinase Expression In Aortocoronary Graft Wallsmentioning

confidence: 99%

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Variability in gelatinase expression in the walls of vessels used as aortocoronary conduits may impact long-term graft patency

et al. 2019

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Background: An imbalance between the activity of matrix metalloproteinases (MMPs), particularly gelatinases, and tissue inhibitors of metalloproteinases (TIMPs) is considered as one of the mechanisms leading to aortocoronary graft failure. Aim: We aimed to assess the variability in gelatinase expression in the walls of aortocoronary conduits and to evaluate its impact on coronary artery bypass grafting (CABG) outcomes. Methods: The study included 101 consecutive patients (61 men and 40 women) who underwent CABG. An immunohistochemical analysis of MMP-2, MMP-9, TIMP-1, and TIMP-2 expression was performed on the cross-sections of the internal thoracic artery (ITA), radial artery (RA), and saphenous vein (SV). The histological findings were compared between patients with SV graft disease (SVGD[+] group) and those without occlusions in the SV (SVGD[-] group). Results: The median MMP and TIMP expression was the weakest in the ITA wall. MMP expression was comparable between the RA and SV cross-sections, whereas TIMP expression was stronger in the RA than in the SV wall (p < 0.05). In most SV segments, but not in the arteries, immunostaining intensity for MMP was comparable to or stronger than for TIMPs. In the veins harvested from the SVGD(+) group, MMP-2 and MMP-9 tissue expression was more pronounced than in the SVGD(-) group. TIMP levels were comparable between groups. Conclusions: Imbalance in the metalloproteinase-to-inhibitor tissue expression in the vessel wall might predispose to graft failure. A stronger expression of TIMPs than MMPs in the arterial grafts might explain favourable long-term outcomes.

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Section: Gelatinase Expression In Aortocoronary Graft Wallssupporting

confidence: 68%

Section: Gelatinase Expression In Aortocoronary Graft Wallsmentioning

confidence: 99%

Variability in gelatinase expression in the walls of vessels used as aortocoronary conduits may impact long-term graft patency

et al. 2019

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“…Theoretically, cryoplasty uses the supercooling and warming cycles to induce a controlled apoptotic response in smooth muscle cells and potentially decrease neointimal hyperplasia or other scar‐forming processes when it is used in blood vessels 15 . It is postulated that by inducing controlled apoptosis on the smooth muscle cells and altering the collagen and extracellular matrix, cryoplasty could potentially change the biomechanics of refractory ureteral strictures 15‐17 . Currently, there are insufficient data to support cryoplasty over plain angioplasty in treatment of peripheral vascular disease 18 .…”

Section: Discussionmentioning

confidence: 99%

“…15 It is postulated that by inducing controlled apoptosis on the smooth muscle cells and altering the collagen and extracellular matrix, cryoplasty could potentially change the biomechanics of refractory ureteral strictures. [15][16][17] Currently, there are insufficient data to support cryoplasty over plain angioplasty in treatment of peripheral vascular disease. 18 Overall success rate of cryoplasty in our series was not statistically different compared to other treatments, although patients did not have to have an extended course of indwelling stents and had less chance of urinary tract infection or other indwelling stent related complications.…”

Section: Ta B L E 4 Stent Dependency and Early Stent Exchangesmentioning

confidence: 99%

Comparison of tandem ureteral stents, cryoplasty, and cutting balloon ureteroplasty in treatment of refractory transplant ureteral strictures

Jalaeian

Talaie

Hunter

et al. 2020

Clinical Transplantation

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The objective of study was to compare clinical outcome of cryoplasty, tandem stents, and cutting balloon ureteroplasty as “bailout procedures” to prevent surgical intervention or stent dependency in renal transplant patients with refractory ureteral stricture. All patients who underwent a bailout procedure from June 11, 2003, to August 8, 2015, at a single institution were reviewed retrospectively. Refractory ureteral stricture was defined as ureteral stenosis not responding to at least two prior percutaneous plain balloon ureteroplasties. Primary patency was defined as stable allograft function following the procedure with unobstructed urine outflow, not requiring indwelling ureteral stent, repeat ureteroplasty, or surgical revision. Sixty‐one procedures were performed on 51 patients. Patients were followed up for a median of 286 days. Overall primary patency rate was 26.1%. Primary patency rate by method was 38.1%, 23.1%, and 14.3% after cryoplasty, tandem stent placement, and cutting balloon dilatation, respectively (P = .260). Primary patency rate was higher in early (<3 months post‐transplant) ureteral strictures (35.7% vs 13.3%; P = .047). More complications identified in patients who had tandem ureteral stents (P = .00754). As some renal transplant patients may not be good operative candidates for ureteral revision, it would be reasonable to attempt one of these “bailout” interventions as long as the clinical team and patient are aware of overall low potential for achieving primary patency.

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Cryoplasty for Canine Iliac Artery Stenosis and its Impact on Expression of TIMP-2 and MMP-2

Abstract: Our study suggests cryoplasty might increase the expression of TIMP-2 and decrease the expression of MMP-2, thereby inhibiting vascular hyperplasia and collagen fibers synthesis of the stenotic vessels.

Cited by 2 publications

References 26 publications

Variability in gelatinase expression in the walls of vessels used as aortocoronary conduits may impact long-term graft patency

Variability in gelatinase expression in the walls of vessels used as aortocoronary conduits may impact long-term graft patency

Comparison of tandem ureteral stents, cryoplasty, and cutting balloon ureteroplasty in treatment of refractory transplant ureteral strictures

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