Cryomicroneedles for transdermal cell delivery

Chang, Hao; Chew, Sharon Wan Ting; Zheng, Mengjia; Lio, Daniel Chin Shiuan; Wiraja, Christian; Yu, Man; Ning, Xiaoyu; Cui, Mingyue; Than, Aung; Shi, Peng; Wang, Dong‐An; Pu, Kanyi; Chen, Peng; Liu, Haiyan; Xu, Chen

doi:10.1038/s41551-021-00720-1

Cited by 115 publications

(113 citation statements)

References 55 publications

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“…To enhance therapeutic efficacy, advanced strategies such as introducing nano/micropores to the needles and integration with drug-loading CaCO 3 microparticles have been developed [ 36–38 ]. Recently, functional cell delivery with a microneedle patch was reported for cells such as mesenchymal stem cells and dendritic cells [ 39 , 40 ]. These strategies extend the application of microneedles in combating various scenarios, including cancer, tissue reconstruction and medical cosmetology, by delivering live cells.…”

Section: Discussionmentioning

confidence: 99%

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

Wang

Archibong

et al. 2021

National Science Review

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Chimeric antigen receptor T cell (CAR T) therapy reached a milestone in the treatment of relapsed and refractory B-cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implemented a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors.

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Section: Discussionmentioning

confidence: 99%

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

Wang

Archibong

et al. 2021

National Science Review

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“…Application of complex and sophisticated fabrication tools with a wide range of materials in the development of MN patches can support local, controllable drug release, several therapeutic factors, and certain cells across cutaneous tissue to the target sites in a broad spectrum of conditions. 173 In a recent experiment, it was shown that ovalbumin-induced dendritic cells loaded inside cryogenic needles can promote antigen processing, leading to tumor mass atresia and the prevention of metastatic cells into the circulation system. 173 Along with these statements, MN patches are suitable candidates for the restoration of injured tissue.…”

Section: Microneedle Technologies In the Context Of Regenerative Medi...mentioning

confidence: 99%

“… 173 In a recent experiment, it was shown that ovalbumin-induced dendritic cells loaded inside cryogenic needles can promote antigen processing, leading to tumor mass atresia and the prevention of metastatic cells into the circulation system. 173 Along with these statements, MN patches are suitable candidates for the restoration of injured tissue. The efficiency and regenerative potential of MN patches have been proved in terms of wound healing, neovascularization, and artificial organ reconstruction.…”

Section: Microneedle Technologies In the Context Of Regenerative Medi...mentioning

confidence: 99%

Application of microneedle patches for drug delivery; doorstep to novel therapies

et al. 2022

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In the past decade, microneedle-based drug delivery systems showed promising approaches to become suitable and alternative for hypodermic injections and can control agent delivery without side effects compared to conventional approaches. Despite these advantages, the procedure of microfabrication is facing some difficulties. For instance, drug loading method, stability of drugs, and retention time are subjects of debate. Besides, the application of novel refining fabrication methods, types of materials, and instruments are other issues that need further attention. Herein, we tried to summarize recent achievements in controllable drug delivery systems (microneedle patches) in vitro and in vivo settings. In addition, we discussed the influence of delivered drugs on the cellular mechanism and immunization molecular signaling pathways through the intradermal delivery route. Understanding the putative efficiency of microneedle patches in human medicine can help us develop and design sophisticated therapeutic modalities.

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“…Cryomicroneedles used for delivery cells could retain their viability and proliferative capability. Biocompatible cryomicroneedles may facilitate minimally invasive cell delivery for a range of cell therapies [ 118 ]. The combination of MN percutaneous delivery with cancer immunotherapy to improve the efficacy of cancer treatment is also an attractive direction.…”

Section: Biomedical Applications and Latest Research Progress Of Mnsmentioning

confidence: 99%

Recent Advances of Microneedles and Their Application in Disease Treatment

Zhang

et al. 2022

IJMS

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For decades, scientists have been doing a lot of research and exploration to find effective long-term analgesic and/or disease-modifying treatments. Microneedles (MNs) are a simple, effective, and painless transdermal drug delivery technology that has emerged in recent years, and exhibits great promise for realizing intelligent drug delivery. With the development of materials science and fabrication technology, the MN transdermal drug delivery technology has been applied and popularized in more and more fields, including chronic illnesses such as arthritis or diabetes, cancer, dermatocosmetology, family planning, and epidemic disease prevention, and has made fruitful achievements. This paper mainly reviews the latest research status of MNs and their fabrication methodology, and summarizes the application of MNs in the treatment of various diseases, as well as the potential to use nanotechnology to develop more intelligent MNs-based drug delivery systems.

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Cryomicroneedles for transdermal cell delivery

Cited by 115 publications

References 55 publications

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

Application of microneedle patches for drug delivery; doorstep to novel therapies

Recent Advances of Microneedles and Their Application in Disease Treatment

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