Cryometry data and excess thermodynamic functions in the binary system: water soluble bis-adduct of light fullerene C70 with lysine. Assymmetrical thermodynamic model of virtual gibbs energy decomposition - VD-AS

Abstract

The temperature of water-ice crystallization initiation decreases (∆T) were determined in the binary water solutions of water soluble derivative of light fullerene C 70 with amino-acid lysine at 272.99 -273.15 K. Partial molar excess functions for H 2 O were calculated. For the thermodynamic description of our systems, we have elaborated an original semi-empirical model VD-AS (Virial Decomposition Asymmetric Model), based on the virial decomposition of the molar Gibbs energy of the component molar fractions in the solution. With the help of the VD-AS model, partial molar functions of nano-clusters were calculated. Excess and full average Gibbs energies for the solutions and miscibility gaps concentration regions (with the help of diffusional instability equations) were calculated. Thus, the VD-AS model excellently describes pre-delamination or micro-heterogeneous-structure formation in the considered solutions. These calculations were accordingly confirmed by dynamic light scattering data.

The use of nanocluster polyoxometalates in the bioactive substance delivery systems

“…This aspect makes fullerenes promising candidates as means of targeted drug delivery. However, fullerenes are hydrophobic, which limits the possibilities of their direct use in biomedicine [193] It is possible to obtain their aqueous dispersions [194][195][196][197][198][199][200] and associates with organic compounds [200][201][202][203][204][205]. One of the ways of modifying the surface of fullerenes provides hydroxylated derivatives such as fullerenols [195,200,205,206,208].…”

“…The absorption of such systems by cells can be realized through specific endocytosis. Another possible trend in the use of fullerenes is the creation of bioactive [203,204,206,208] or contrast materials for nuclear magnetic resonance imaging (MRI) through internal functionalization by contrast agents, including Gd 3+ , Sc 3+ , Ho 3+ , Tm 2+ , Ga 3+ and Tc 2+ ions, with isolation of unstable and potentially toxic contrast materials from the internal medium of the body [209][210][211][212]. A similar solution for creating contrast materials is proposed in [213] for Keplerates, the non-carbon analogs of fullerenes which form ionic associates with cations of the above-mentioned metals.…”