Cryolipolysis for Reduction of Excess Adipose Tissue

Nelson, Andrew A.; Wasserman, Daniel I.; Avram, Mathew M.

doi:10.1016/j.sder.2009.11.004

Cited by 81 publications

(71 citation statements)

References 13 publications

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“…Cerca de 3 dias após o tratamento, os adipócitos são rodeados por linfócitos, neutrófilos e outras células monomorfonucleares e a partir disso o processo inflamatório tem início.Posteriormente, entre 14 e 30 dias,os macrófagos fagocitam os corpúsculos apoptóticosdo tecido adiposo e após 4 semanas ocorre uma redução da quantidade de adipócitos com efetiva eliminação destes ao longo Tabela 1. Súmula dos artigos categorizados com seus respectivos escores de qualidade (continuação) de 90 dias 3,12 .…”

Section: Resultsunclassified

“…. A partir deste crescente interesse pelo desenvolvimento de tratamentos capazes de reduzir a adiposidade localizada, muita ênfase tem sido direcionada à técnica de criolipólise, uma vez que se trata de um recurso não invasivo que promove o remodelamento corporal 2,3 .…”

Section: Resumo | Introduçãounclassified

“…Apesar da explicação mais provável para que esta redução seja sustentada pela ocorrência de apoptose, a imunopatogênese deste processo neste contexto ainda não foi totalmente elucidada. Alguns autores sugerem que a morte celular programada seja induzida pelo processo inflamatório 3,11,12 , ao passo que outros estudos defendem a premissa de que a gordura eliminada através da técnica de criolipólise seja metabolizada pela mesma via natural do metabolismo de gordura 2 .…”

Section: Resumo | Introduçãounclassified

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Criolipólise: Aplicabilidade Clínica E Perspectivas Da Terapêutica Na Adiposidade Localizada - Uma Revisão Sistemática

Ferreira¹,

Medrado

2017

RPF

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| Introduction:The cryolipolysis, despite being a cosmetic treatment described recently in the literature, is a therapeutic option that has theoretical and practical grounds that indicate positive results in the reduction of localized fat. Objective: To systematically review the clinical applicability of cryolipolisys and document its effectiveness in patients with localized adiposity within the selectedphysiotherapy dermato functional. Methodology: Were selected scientific articles classified as RCTs or not in the databases Pubmed and Bireme between the periods 2010 to 2016. The research was conducted under the PRISMA methodology. The manuscripts included were analyzed qualitatively according to JADAD scale and reviewed by two independent reviewers. Results: Of the 210 articles identified in databases, 9 manuscripts were included for analysis, with a total sample of 234 individuals with adiposity localized level of quality of the studies was 2.1. Different anatomical areas were evaluated in the studies compiled with emphasis on thighs, flanks, arms and abdomen. There was also a high degree of satisfaction by participants. Conclusion:The level of quality of existing clinical trials in the literature was considered low, despite the fact that they are published in high impact journals. Randomization sample represented the critical point for most of the manuscripts. It is a suggested to conduct more randomized clinical trials to the theoretical and practical basis of cryolipolysis technique.Keywords: Adipocytes; Adiposity; Lipolysis. RESUMO | Introdução:A criolipólise, apesar de ser um tratamento estético recentemente descrito na literatura, é uma opção terapêutica queapresenta fundamentos teóricos e práticos cujos resultados na redução da gordura localizada indicam serem positivos. Objetivo: Realizar uma revisão sistemática para relatar a aplicabilidade clínica da criolipólise e documentar a sua eficácia em pacientes com adiposidade localizada, no âmbito da Fisioterapia Dermatofuncional. Metodologia: Foram selecionados artigos científicos classificados como ensaios clínicos randomizados ou não nas bases de dados PubMed e Bireme entre os períodos de 2010 a 2016. A pesquisa foi conduzida conforme a metodologia PRISMA. Os manuscritos incluídos foram analisados qualitativamente segundo a escala JADAD e revisados por dois avaliadores independentes. Resultados: Dos 210 artigos identificados nas bases de dados, 9 manuscritos foram incluídos para análise, com amostra total de 234 indivíduos com adiposidade localizada. O nível dequalidade dos estudos foi 2,1. Diferentes áreas anatômicas foram avaliadas nos estudos compilados com ênfase para coxas, flancos, braços e abdômen. Observou-se também, um grau de satisfação alto por parte dos participantes. Conclusão: Concluiu-se que, o nível de qualidade dos ensaios clínicos existentes na literatura foi considerado baixo, a despeito do fato de serem publicados em periódicos de alto impacto. A randomização da amostra representou o ponto crítico para a maioria dos manuscrit...

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Section: Resultsunclassified

Section: Resumo | Introduçãounclassified

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Criolipólise: Aplicabilidade Clínica E Perspectivas Da Terapêutica Na Adiposidade Localizada - Uma Revisão Sistemática

Ferreira¹,

Medrado

2017

RPF

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“…The main Cryo device investigated was CoolSculpting (Zeltiq) 10-11, 18, 41-54 , which has also had review articles published specific to the modality [41][42][43] . Only one treatment was usually necessary but diminishing returns with additional treatments were reported 18 and onset took about 8 weeks 11,44 .…”

Section: Cryomentioning

confidence: 99%

Noninvasive Body Contouring: Literature Review and Summary of Objective Data

Bernstein

Farberg²,

Khorasani³

et al. 2017

J of Skin

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Capsule Summary:• Noninvasive body contouring devices vary by efficacy, treatment schedule and safety profile.• This review compares body contouring modalities, allowing for quick comparison between modalities.• This review enables the selection of a body contouring modality that best suits each specific patient's goals, availability and aversion to risk. Background: There is increasing demand for noninvasive body contouring but objective data is difficult to compare between modalities. Currently, the most accepted forms of noninvasive body contouring are cryolipolyisis (Cryo), focused ultrasound (FUS), radiofrequency (RF), and low level laser therapy (LLLT). AbbreviationsObjective: To summarize the objective data on noninvasive body contouring. Methods:In October 2016, a pubmed search was performed with terms "noninvasive body contouring" or "non-invasive body contouring." The search was limited to human studies in English on the four major modalities.Results: 55 articles yielded data from 3649 patients. The most well studied modality was Cryo and the least was RF. Decreased abdominal/flank localized adiposity was most the most common endpoint reported. Both the minimum and maximum reported decreases in abdominal girth were from studies using RF (1.4cm and 7.4cm, respectively). Side effects were most common and significant with Cryo and absent with LLLT. Conclusions:Noninvasive body contouring has a significant amount of objective data available in the literature to date. Reductions of localized adiposity are clinically and statistically significant but modest. To date, the best reported positive results have been obtained with RF and the lowest risk of side effects is with LLLT. ABSTRACT SKINJuly 2017 Volume I Issue I

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“…Adipocytes undergo a severe apoptotic process following cold exposing. Injured adipocytes then suffer from an inflammatory clearing procedure (4,5). Subsequently, about 3 days after cold exposure, this cold-induced inflammation is terminated in perivascular infiltration of histiocytes and lymphocytes at the dermal-subdermal junction that ultimately extends into the subcutaneous fat tissue (6).…”

Section: Introductionmentioning

confidence: 99%

Simulation of cryolipolysis as a novel method for noninvasive fat layer reduction

Majdabadi¹,

Abazari²

2016

Turk J Med Sci

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Background/aim: Regarding previous problems in conventional liposuction methods, the need for development of new fat removal operations was appreciated. In this study we are going to simulate one of the novel methods, cryolipolysis, aimed to tackle those drawbacks. Materials and methods:We think that simulation of clinical procedures contributes considerably in efficacious performance of the operations. To do this we have attempted to simulate temperature distribution in a sample fat of the human body. Using Abaqus software we have presented the graphical display of temperature-time variations within the medium.Results: Findings of our simulation indicate that tissue temperature decreases after cold exposure of about 30 min. It can be seen that the minimum temperature of tissue occurs in shallow layers of the sample and the temperature in deeper layers of the sample remains nearly unchanged. It is clear that cold exposure time of more than the specific time (t > 30 min) does not result in considerable changes. Conclusion:Numerous clinical studies have proved the efficacy of cryolipolysis. This noninvasive technique has eliminated some of drawbacks of conventional methods. Findings of our simulation clearly prove the efficiency of this method, especially for superficial fat layers.

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Cryolipolysis for Reduction of Excess Adipose Tissue

Cited by 81 publications

References 13 publications

Criolipólise: Aplicabilidade Clínica E Perspectivas Da Terapêutica Na Adiposidade Localizada - Uma Revisão Sistemática

Criolipólise: Aplicabilidade Clínica E Perspectivas Da Terapêutica Na Adiposidade Localizada - Uma Revisão Sistemática

Noninvasive Body Contouring: Literature Review and Summary of Objective Data

Simulation of cryolipolysis as a novel method for noninvasive fat layer reduction

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