Cryoglobulinemia

Trejo, Olga; Ramos-Casals, Manuel; Garcı́a-Carrasco, Mario; Yagüe, Jordi; Jiménez, Sònia; Red, Gloria de la; Cervera, Ricard; Font, Josep; Ingelmo, M

doi:10.1097/00005792-200107000-00004

Cited by 256 publications

(66 citation statements)

References 40 publications

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“…These cryoglobulins were tentatively named type II-III variant cryoglobulins [135]. Oligoclonal cryoglobulins have been also reported in 7 out of 443 cases by other authors [127].…”

Section: Specialized Techniques -Particular Clinical Situationsmentioning

confidence: 77%

“…Most frequently, the precipitates contain Igs, and are therefore called cryoglobulins [123]. Cryoglobulins have been observed in a wide variety of disorders, including malignancies, infections and systemic autoimmune diseases [123][124][125][126][127]. Three types of cryoglobulins have been described: type I contains a single monoclonal Ig, whereas type II is a mixture of a monoclonal Ig with polyclonal Igs (Fig.…”

Section: Specialized Techniques -Particular Clinical Situationsmentioning

confidence: 99%

“…Most frequently, cryoprecipitates are characterized using IF [123,124,126,[129][130][131]. Type II and type III are also called mixed cryoglobulins, and are most frequently observed in patients with hepatitis C virus infection [123,124,126,127]. A new type of mixed cryoglobulins, named type II-III, has been identified.…”

Section: Specialized Techniques -Particular Clinical Situationsmentioning

confidence: 99%

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The immunoglobulinopathies: From physiopathology to diagnosis

Tissot

Aubert

et al. 2002

Proteomics

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The diversity of immunoglobulins (Igs) results mainly from recombinations of numerous genes within the heavy (V(Heavy), D, and J(Heavy)) and within the light (V(Light), J(Light)) chain gene loci, and from somatic hypermutations occurring during the immune response of B-cells. Igs production is controlled by complex cellular and humoral mechanisms. Plasma of healthy individuals contains polyclonal Igs. Clonal expansion of cells producing antigen-specific Igs may result from physiological as well as from pathological immune events. Exquisitely sensitive and specific molecular biology techniques have been used to evaluate the clonal diversity of cells producing antigen-specific Ig. However, the application of such techniques is hampered by the necessity to collect the totality of antigen-specific B-cells for subsequent analysis, which is impossible to perform routinely in humans. In addition, these techniques do not provide quantitative information about the concentration of the circulating Igs. It is therefore necessary to use tools allowing study of the quantity of the circulating Igs, and more particularly to detect overproduction of a single homogeneous Ig resulting from the expansion of a B-cell clone secreting Igs. Here, we review the mechanisms of B-cell differentiation and Ig synthesis, discuss the diseases associated with clonal Ig production and review the methods available in the clinical laboratory for Ig analysis.

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“…These cryoglobulins were tentatively named type II-III variant cryoglobulins [135]. Oligoclonal cryoglobulins have been also reported in 7 out of 443 cases by other authors [127].…”

Section: Specialized Techniques -Particular Clinical Situationsmentioning

confidence: 77%

Section: Specialized Techniques -Particular Clinical Situationsmentioning

confidence: 99%

Section: Specialized Techniques -Particular Clinical Situationsmentioning

confidence: 99%

See 1 more Smart Citation

The immunoglobulinopathies: From physiopathology to diagnosis

Tissot

Aubert

et al. 2002

Proteomics

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“…The latter two types of cryoglobulinemia are associated with HCV infection, particularly with type II cryoglobulinemia [6]. However, HBV infection may also be involved in the pathogenesis of this complication [10], although the prevalence of HBV in MC patients is not as high [11]. A case of cryoglobulinemia onset after HBV vaccination has also been reported [12].…”

Section: Cryoglobulinemia Associated With Hepatitis Virus Infectionmentioning

confidence: 99%

Clinical Features of Vascular Disorders Associated with Chronic Hepatitis Virus Infection

Nishida

Kudo²

2014

Dig Dis

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Hepatitis virus infections can be accompanied by extrahepatic manifestations that may be caused by the host's immune reaction to the viral infection. Vascular involvement is one of these manifestations and is occasionally associated with life-threatening conditions due to systemic organ failure. The unique profile of hepatitis-related vascular involvement is associated with infection by different types of hepatitis viruses. For example, polyarteritis nodosa is more frequently reported in patients with chronic hepatitis B than those with chronic hepatitis C. Similarly, membranous nephropathy is a notable manifestation among hepatitis B virus-positive patients. In contrast, patients infected with hepatitis C virus are at risk for cryoglobulinemia and membranoproliferative glomerulonephritis. Antiviral therapy is necessary to control these kinds of vasculitis related to hepatitis virus infections; however, immunosuppressive agents may be required to treat severe cases. New antiviral drugs for viral hepatitis could improve the prognosis of vascular and renal involvement.

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“…Depuis l'identification du virus de l'hépatite C (VHC), de nombreux auteurs ont démontré que l'infection par le VHC était la cause de 70 à 90 % des cas de CM. Le VHC est surtout associé aux CM de type II (IgMk), plus rarement de type III [1][2][3]. Dans une minorité de cas (< 5 %), aucune cause n'est identifiée et la CM est dite « essentielle ou idiopathique ».…”

Section: Points Essentielsunclassified

Rein et cryoglobulinémies mixtes : quel traitement ?

Cacoub

2012

La Presse Médicale

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Cryoglobulinemia

Cited by 256 publications

References 40 publications

The immunoglobulinopathies: From physiopathology to diagnosis

The immunoglobulinopathies: From physiopathology to diagnosis

Clinical Features of Vascular Disorders Associated with Chronic Hepatitis Virus Infection

Rein et cryoglobulinémies mixtes : quel traitement ?

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