Cryoballoon ablation dosing: From the bench to the bedside and back

Aryana, Arash; Braegelmann, Kendra M.; Lim, Hae W.; Ellenbogen, Kenneth A.

doi:10.1016/j.hrthm.2020.02.029

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…To develop CB ablation catheters that deliver cryoenergy to isolate the PVs, it is crucial to understand the biophysical parameters of cryothermal injury [7]. Cardiac cells can be rendered electrically dormant at a temperature of 20-25 °C.…”

Section: Comparison With Arctic Front™ Cryoballoonmentioning

confidence: 99%

Key characteristics for effective acute pulmonary vein isolation when using a novel cryoballoon technology: insights from the CHARISMA registry

Iacopino

Stabile

Fassini

et al. 2021

J Interv Card Electrophysiol

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Purpose A new cryoballoon (CB) technology (POLARx™; Boston Scientific) for pulmonary vein (PV) isolation in patients with atrial fibrillation (AF) has recently been introduced. The aim of this study was to evaluate procedural and biophysical parameters resulting in acute PV isolation when using this new CB. Methods We assessed the first 69 consecutive patients indicated for AF ablation who underwent PV isolation by means of a novel CB system. Procedural metrics were prospectively recorded. Results A total of 274 PVs were targeted in 69 patients. PV isolation was achieved in all patients by means of cryoablation alone. The median time to isolation (TTI) was 44 s (median temperature at TTI = − 49 [− 53 to − 41] °C). The median duration of CB ablation was 180 [180 to 240] s. The median nadir temperature was − 56.0 [− 61 to − 52] °C, and the median thaw time to 0 °C was 18 [15-21] s. The median grade of PV occlusion was 4 [3 to 4]. On the basis of ROC analysis, we defined the following cut-off values for acute PV isolation:

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Section: Comparison With Arctic Front™ Cryoballoonmentioning

confidence: 99%

Key characteristics for effective acute pulmonary vein isolation when using a novel cryoballoon technology: insights from the CHARISMA registry

Iacopino

Stabile

Fassini

et al. 2021

J Interv Card Electrophysiol

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“…The extreme hypothermia produced by liquified argon results in ice crystal formation within tumor cells and lead to tumor necrosis. The cryoballoon and cryoICE cryoablation probe, were originally designed for pulmonary vein isolation in patients with atrial fibrillation, and can both produce profound transmural penetration of the lethal temperature [18,19].…”

Section: Treatment Of Cardiac Intimal Sarcomamentioning

confidence: 99%

Primary Cardiac Intimal Sarcoma with Extensive Left Atrial Involvement Treated with Cryoablation

2022

J Surg

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A primary cardiac tumor is extremely rare. The majority of primary cardiac tumors are benign, and approximately onequarter are malignant. The most common type of cardiac tumor is cardiac myxoma, which is usually located in the left atrium. Aside from the above, the majority of these malignant tumors are sarcomas, which can be distinguished by their different histologies. However, the differential diagnosis between benign myxomas and malignant sarcomas might be challenging in certain cases, and a high index of clinical suspicion and vimentin staining can be useful in making the diagnosis. In this case report, we present a young female who received an operation for a tumor of the left atrium that was initially diagnosed as a myxoma but later recurred as a myxofibrosarcoma. As a consequence of the immunoreactive results of MDM2 amplification, cardiac intimal sarcoma was finally diagnosed. It is notable that surgical removal of the primary tumor with extensive cryoablation of horizontal tumor spreading using a cryoballoon and cryoablation probe, which are initially designed for pulmonary vein isolation and Maze procedure, incorporated with postoperative radiotherapy, chemotherapy, and surgery to remove the costal bone metastasis effectively prevents the disease from relapsing and recurrences.

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Cryoballoon ablation dosing: From the bench to the bedside and back

Cited by 2 publications

References 47 publications

Key characteristics for effective acute pulmonary vein isolation when using a novel cryoballoon technology: insights from the CHARISMA registry

Key characteristics for effective acute pulmonary vein isolation when using a novel cryoballoon technology: insights from the CHARISMA registry

Primary Cardiac Intimal Sarcoma with Extensive Left Atrial Involvement Treated with Cryoablation

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