Cryo EM structures map a post vaccination polyclonal antibody response to canine parvovirus
Samantha R. Hartmann,
Andrew J. Charnesky,
Simon P. Früh
et al.
Abstract:Canine parvovirus (CPV) is an important pathogen that emerged by cross-species transmission to cause severe disease in dogs. To understand the host immune response to vaccination, sera from dogs immunized with parvovirus are obtained, the polyclonal antibodies are purified and used to solve the high resolution cryo EM structures of the polyclonal Fab-virus complexes. We use a custom software, Icosahedral Subparticle Extraction and Correlated Classification (ISECC) to perform subparticle analysis and reconstruc… Show more
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