Cryo-EM structure of the bicarbonate receptor GPR30
Shota Kaneda,
Airi Jo-Watanabe,
Hiroaki Akasaka
et al.
Abstract:G-protein-coupled receptor 30 (GPR30) is a bicarbonate receptor that plays a vital role in cellular responses to extracellular pH and ion homeostasis. Despite its significance, the mechanisms by which GPR30 interacts with bicarbonate ions remain elusive. There is no consensus on a drug that targets GPR30, and the difficulty in the pharmacological analysis has limited biological and drug discovery researches on GPR30. Here, we present the cryo-electron microscopy structure of human GPR30 in the presence of bica… Show more
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