Cryo-EM structure of mouse TRPML2 in lipid nanodiscs

Abstract

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Polycystin Channel Complexes

“…The TOP domain sits on the extracellular side of the VSD, extending from the S1 and S2 helices to form extracellular contacts with the S3-S4 loop (Figures 1a and 2a). Although this protein fold is unique to polycystins, it is structurally similar to the extraluminal domain of the lysosomal mucolipin TRP channels (48,49).…”

Coordinating activation of endo‐lysosomal two‐pore channels and TRP mucolipins

“…High-resolution structures of TPCs and TRPMLs have been obtained by cryo-EM in recent years (Fig. 1) (Dickinson et al, 2020;Fine et al, 2018;She et al, 2018She et al, , 2019Song et al, 2022;Zhou et al, 2017). This has provided novel molecular insights into channel regulation by stimuli such as PI(3,5)P 2 and voltage.…”