2024
DOI: 10.1101/2023.12.31.573132
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Cryo-EM images of phase separated lipid bilayer vesicles analyzed with a machine learning approach

Karan D. Sharma,
Milka Doktorova,
M. Neal Waxham
et al.

Abstract: Lateral lipid heterogeneity (i.e., raft formation) in biomembranes plays a functional role in living cells. Three-component mixtures of low- and high-melting lipids plus cholesterol offer a simplified experimental model for raft domains in which a liquid-disordered (Ld) phase coexists with a liquid-ordered (Lo) phase. Using such models, we recently showed that cryogenic electron microscopy (cryo-EM) can detect phase separation in lipid vesicles based on differences in bilayer thickness. However, the considerab… Show more

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