Crying with depressed affect induced by electrical stimulation of the anterior insula: A stereo EEG case study

Singh, Thakar; Sabsevitz, David S.; Desai, Nimit; Middlebrooks, Erik H.; Feyissa, Anteneh M.; Grewal, Sanjeet S.; Wharen, Robert E.; Tatum, William O.; Ritaccio, Anthony L.

doi:10.1016/j.ebr.2020.100421

Cited by 3 publications

(4 citation statements)

References 17 publications

(13 reference statements)

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“…This results extends to humans previous findings from mice showing distinct areas within the insula controlling approach vs. avoidance behavior (Peng et al, 2015;Wang et al, 2018). Our findings also bridges with stimulation studies in non-human primates where stimulation of the ventral aIns reduced approach behaviors in appetitive contexts (Saga et al, 2019) and was associated with negative behaviors such as disgust (Caruana et al, 2011;Jezzini et al, 2012;Krolak-Salmon et al, 2003) or depression (Singh et al, 2021). Conversely, iES on the dorsal aIns has been more commonly associated with positive behaviors such as ingestion in monkeys (Jezzini et al, 2012) or even ecstatic feelings in rare case studies in humans (Bartolomei et al, 2019;Nencha et al, 2022;Picard et al, 2013).…”

Section: Discussionsupporting

confidence: 88%

“…To address these challenges, we conducted an experiment using intracranial electrical stimulation (iES) over human cortex to determine whether iES can disrupt choice behavior and also confidence judgments using a previously validated accept/reject task (Cecchi et al, 2022; Vinckier et al, 2018). Previous research has indicated that iES of the ventral aIns elicits disgust behavior or depressed affect (Caruana et al, 2011; Jezzini et al, 2012; Krolak-Salmon et al, 2003; Singh et al, 2021), whereas iES of the dorsal aIns elicits overwhelming ecstatic sensations or ingestive behavior, such as chewing and swallowing (Bartolomei et al, 2019; Jezzini et al, 2012; Nencha et al, 2022; Picard et al, 2013). Expanding on this evidence, we posit that harnessing the high spatial resolution of the iES will allow us to uncover functional circuits causally related to choice behavior.…”

Section: Main Textmentioning

confidence: 99%

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Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices

Cecchi,

Collomb-Clerc,

Rachidi

et al. 2023

Preprint

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Neural activities within the ventromedial prefrontal cortex and anterior insula are associated with economic choices. However, whether these brain regions are causally related to these processes remains unclear. To address this issue, we leveraged rare intracerebral electrical stimulation (iES) data in epileptic patients. We show that opposite effects of iES on choice depend on the location of stimulation on a dorso-ventral axis within each area, thus demonstrating dissociable neural circuits causally involved in accepting versus avoiding challenges.

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Section: Discussionsupporting

confidence: 88%

Section: Main Textmentioning

confidence: 99%

Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices

Cecchi,

Collomb-Clerc,

Rachidi

et al. 2023

Preprint

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“…Ictal depression or sadness has been reported by 1% of patients with focal epilepsy arising from the temporal lobe [213, 221] (rarely during electrical cortical stimulation). They can also occur in seizures arising from the mesial temporal region [120], orbito‐frontal cortex [196], and the anterior insula in a single patient during electrical stimulation studies [228]. Seizures associated with sadness often accompany seizures with laughing in the setting of a hypothalamic hamartoma.…”

Section: Affective (Emotional) Featuresmentioning

confidence: 99%

“…Sadness during seizures reflects the condition or quality of feeling sad or being unhappy and encompassing a feeling or showing sorrow. The lateralization is ill-defined and uncertain though the left hemisphere has demonstrated symptoms of sadness [120,196,228]. Ictal depression or sadness has been reported by 1% of patients with focal epilepsy arising from the temporal lobe [213,221] (rarely during electrical cortical stimulation).…”

Section: Sadnessmentioning

confidence: 99%

Seizure semiology: ILAE glossary of terms and their significance

Beniczky¹,

Tatum²,

Blumenfeld³

et al. 2022

Epileptic Disorders

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The relationship between crying of premature infants with Monro-kellie hypothesis and increase of ventricular CSF Based on Doppler ultrasound findings

Ijabi

Tehranian

Afrisham

et al. 2022

Preprint

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Introduction: Infant crying causes an increase in intracranial pressure which is equivalent to a decrease in CSF and also a decrease in CSF before ischemic and hemorrhagic strokes observed. The object of this study is to evaluate the effect of crying on premature infant brain pressure and the effect of crying on brain autoregulation. Method: In a case-control study, the participants were 53 premature infants with the ability to cry and 43 non-crying premature. Apgar score and after birth blood gases were estimated, and 200 µl capillary samples were collected from the heel for assessment of blood gases before,during and after crying. A transcranial Doppler device used to measure cerebral blood flow volume (CBFV) levels and compared in three sections during, before, and after crying. Results: The CO2 higher level was during crying in comparison with after and before crying (P<0.001). The brain volume was enlarger during crying than after and before crying, as well (P<0.001). The Doppler ultrasound results showed that the higher resistive index (RI) and pulsatility index (PI) occurred during crying than after and before crying (P<0.001). There was the lowest end-diastolic velocity (EDV) and Peak systolic velocity (PSV) during crying than after and before crying (P=0.001).Conclusion: The results suggest that the brain volume has increased during crying, which is associated with simultaneous entry of CSF. In intracranial hemorrhage (IH), there is a decrease in CSF which is accompanied by a decrease in brain activity. Therefore, crying with an increased CSF and brain magnetic activity can probably prevent IH.

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Crying with depressed affect induced by electrical stimulation of the anterior insula: A stereo EEG case study

Cited by 3 publications

References 17 publications

Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices

Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices

Seizure semiology: ILAE glossary of terms and their significance

The relationship between crying of premature infants with Monro-kellie hypothesis and increase of ventricular CSF Based on Doppler ultrasound findings

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