Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population

Hua, Peng; Liu, Weiguo; Chen, Donghui; Zhao, Yanyan; Chen, Ling; Zhang, Ning; Wang, Chun; Guo, Suwan; Wang, Li; Xiao, Hong; Kuo, Sheng‐Han

doi:10.1016/j.jad.2013.11.019

Cited by 73 publications

(49 citation statements)

References 30 publications

(36 reference statements)

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“…CRY1 , a protein-coding gene, plays a major role in repressing the transcription of CLOCK/BMAL1 and activating the transcription of PER (Ko & Takahashi, 2006; Weger et al, 2011; Hua et al, 2014). An interaction between CRY1 rs10746075 and number of years since HIV diagnosis was associated with circadian quotient.…”

Section: Discussionmentioning

confidence: 99%

Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV

Lee

Byun

Lerdal

et al. 2015

Chronobiology International

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Genes involved in circadian regulation, such as circadian locomotor output cycles kaput [CLOCK], cryptochrome [CRY1], and period [PER], have been associated with sleep outcomes in prior animal and human research. However, it is unclear whether polymorphisms in these genes are associated with the sleep disturbances commonly experienced by adults living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Thus, the purpose of this study was to describe polymorphisms in selected circadian genes that are associated with sleep duration or disruption as well as the sleep-wake rhythm strength and phase timing among adults living with HIV/AIDS. A convenience sample of 289 adults with HIV/AIDS was recruited from HIV clinics and community sites in the San Francisco Bay Area. A wrist actigraph was worn for 72 hours on weekdays to estimate sleep duration or total sleep time (TST), sleep disruption or percentage of wake after sleep onset (WASO), and several circadian rhythm parameters: mesor, amplitude, the ratio of mesor to amplitude (circadian quotient), and 24-hour autocorrelation. Circadian phase measures included clock time for peak activity (acrophase) from actigraphy movement data, and bed time and final wake time from actigraphy and self-report. Genotyping was conducted for polymorphisms in 5 candidate genes involved in circadian regulation: CLOCK, CRY1, PER1, PER2, and PER3. Demographic and clinical variables were evaluated as potential covariates. Interactions between genotype and HIV variables (i.e., viral load, years since HIV diagnosis) were also evaluated. Controlling for potentially confounding variables (e.g., race, gender, CD4+ T-cell count, waist circumference, medication use, smoking, depressive symptoms), CLOCK was associated with WASO, 24-hour autocorrelation, and objectively-measured bed time; CRY1 was associated with circadian quotient; PER1 was associated with mesor and self-reported habitual wake time; PER2 was associated with TST, mesor, circadian quotient, 24-hour autocorrelation, and bed and wake times; PER3 was associated with amplitude, 24-hour autocorrelation, acrophase, and bed and wake times. Most of the observed associations involved a significant interaction between genotype and HIV. In this chronic illness population, polymorphisms in several circadian genes were associated with measures of sleep disruption and timing. These findings extend the evidence for an association between genetic variability in circadian regulation and sleep outcomes to include the sleep-wake patterns experienced by adults living with HIV/AIDS. These results provide direction for future intervention research related to circadian sleep-wake behavior patterns.

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Section: Discussionmentioning

confidence: 99%

Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV

Lee

Byun

Lerdal

et al. 2015

Chronobiology International

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“…While the role of the circadian system was discovered relatively early in seasonal affective and bipolar disorders, involvement in MDD appeared to be rather uncertain for quite some time. To date polymorphisms of Per3, Cry1, Clock and Npas2 were reported to be associated with MDD (Hua et al, 2014;Shi et al, 2016;Virginia Soria et al, 2010),…”

Section: Insert Table 1 About Herementioning

confidence: 99%

Depressive disorders: Processes leading to neurogeneration and potential novel treatments

Brown

McIntyre

Rosenblat

et al. 2018

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…On the other hand, CRY1 has earlier been associated with depression (Soria et al, 2010;Hua et al, 2014) and nominally significant association has been observed with lithium treatment response for bipolar disorder . However, no association with bipolar disorder has been observed (Shi et al, 2008;Nievergelt et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

CRY1 and CRY2 genetic variants in seasonality: A longitudinal and cross-sectional study

Kovanen

Donner

Kaunisto

et al. 2016

Psychiatry Research

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Cryptochromes are key components of the circadian clocks that generate and maintain seasonal variations. The aim of our study was to analyze the associations of CRY1 and CRY2 genetic variants with the problematicity of seasonal variations, and whether the problematicity of seasonal variations changed during the follow-up of 11 years. Altogether 21 CRY1 and 16 CRY2 single-nucleotide polymorphisms (SNPs) were genotyped and analyzed in 5910 individuals from a Finnish nationwide population-based sample who had filled in the self-report on the seasonal variations in mood and behavior in the year 2000. In the year 2011, 3356 of these individuals filled in the same self-report on the seasonal variations in mood and behavior. Regression models were used to test whether any of the SNPs associated with the problematicity of seasonal variations or with a change in the problematicity from 2000 to 2011. In the longitudinal analysis, CRY2 SNP rs61884508 was protective from worsening of problematicity of seasonal variations. In the cross-sectional analysis, CRY2 SNP rs72902437 showed evidence of association with problematicity of seasonal variations, as did SNP rs1554338 (in the MAPK8IP1 and downstream of CRY2).

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Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population

Cited by 73 publications

References 30 publications

Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV

Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV

Depressive disorders: Processes leading to neurogeneration and potential novel treatments

CRY1 and CRY2 genetic variants in seasonality: A longitudinal and cross-sectional study

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