Crusted scabies in a girl with epidermolysis bullosa simplex

Torrelo, Antonio; Zambrano, Antonio

doi:10.1046/j.1365-2133.2000.03281.x

Cited by 19 publications

(7 citation statements)

References 15 publications

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“…If the nail scabies in our case had not been treated properly, a relapse of scabies might have occurred, as in the patients reported by Judge (34). In some cases, relapse occurred after six to twelve months, even though the patient had been treated with two or three doses of ivermectin (19,22,30,35). By using molecular analysis of Sarcoptes scabiei, Walton concluded that, in the majority of recurrent cases, the problem was reinfestation rather than recrudescence, but there were some recrudescent cases as well, because the genetic markers of the mites were the same in both the initial and subsequent infections (35).…”

Section: Discussionmentioning

confidence: 66%

“…Since 1993, many reports have confirmed the efficacy of oral ivermectin in the treatment of scabies. This drug has been used not only for common scabies (4-12, 14-16), but also for crusted scabies (8,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Furthermore, in nursing homes, oral ivermectin has been used to control the outbreak of scabies with success (31,32).…”

Section: Discussionmentioning

confidence: 99%

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Oral Ivermectin Treatment in Two Cases Of Scabies: Effective in Crusted Scabies Induced by Corticosteroid but Ineffective in Nail Scabies

Ohtaki

Taniguchi

Ohtomo

2003

The Journal of Dermatology

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We report two cases of scabies treated with oral ivermectin (200 micro g/kg). Case 1, a 72-year-old man, developed crusted scabies with the use of oral corticosteroids due to a misdiagnosis by an earlier physician. The patient was successfully treated with two doses of oral ivermectin at a 7 day interval with concomitant topical use of crotamiton and keratolytic agents. However, the nail scabies in this patient failed to respond to these treatments. Live mites were detected from all his toenails two weeks after the second dose of ivermectin. A complete cure of the nail scabies was achieved by occlusive dressing of 1% gamma-BHC on all toenails for one month. Case 2, a 52-year-old woman, had been treated with oral corticosteroid for mesangial nephritis. She developed common scabies, but a topical scabicide, crotamiton, was not effective. Two weeks after treatment with a single dose of oral ivermectin, eggs were still detected from a burrow on her trunk. Her treatment was completed after a further two doses of oral ivermectin were administered at 7 day intervals. In both patients, the administration of oral ivermectin did not induce any clinical or laboratory side effects. Oral ivermectin is effective for crusted scabies, but not effective for nail scabies. Two doses of oral ivermectin, administered with a one-week interval, is an appropriate treatment regimen.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Oral Ivermectin Treatment in Two Cases Of Scabies: Effective in Crusted Scabies Induced by Corticosteroid but Ineffective in Nail Scabies

Ohtaki

Taniguchi

Ohtomo

2003

The Journal of Dermatology

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“…On removal of the crust, the skin surface appears smooth, velvety, and red [8]. Crusted scabies usually occurs in immunocompromised individuals such as those with congenital immunodeficiency disorders (especially cell-mediated immunodeficiency), acquired immunodeficiency syndrome (AIDS)/human immunodeficiency virus (HIV) infection, immunosuppressive treatment (e.g., corticosteroids, calcineurin inhibitors, and cytotoxic drugs), graft-versus-host disease, malignancies (e.g., leukemia and lymphoma), and systemic diseases (diabetes mellitus, systemic lupus erythematosus, dermatomyositis, chronic mucocutaneous candidiasis, and dystrophic epidermolysis bullosa) [6, 8, 10, 11]. Other predisposing factors include malnutrition, physical debilitation (senility, sensory or motor neuropathy, leprosy, and paraplegia), and mental retardation (especially Down syndrome) [2, 5, 8, 12, 13].…”

Section: Discussionmentioning

confidence: 99%

Pruritic Crusted Scabies in an Immunocompetent Infant

Leung

Leong

Lam

2019

Case Reports in Pediatrics

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Crusted scabies (also known as Norwegian scabies) is a highly contagious variant of scabies characterized by profuse proliferation of mites in the skin and widespread, crusted, hyperkeratotic papules, plaques, and nodules. Typically, pruritus is minimal or absent. The condition usually occurs in immunocompromised individuals. Occurrence in healthy infants has rarely been reported. We report an 11-month-old healthy Malay boy who presented with crusted scabies.

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“…• Ivermectin represents a valid alternative to standard topical treatment for parasitic infestations in EB patients with generalized disease [96,97]. …”

Section: Care Of the Eb Newborn And Infantmentioning

confidence: 99%

Multicentre consensus recommendations for skin care in inherited epidermolysis bullosa

Hachem

Zambruno

Bourdon-Lanoy

et al. 2014

Orphanet J Rare Dis

140

136

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BackgroundInherited epidermolysis bullosa (EB) comprises a highly heterogeneous group of rare diseases characterized by fragility and blistering of skin and mucous membranes. Clinical features combined with immunofluorescence antigen mapping and/or electron microscopy examination of a skin biopsy allow to define the EB type and subtype. Molecular diagnosis is nowadays feasible in all EB subtypes and required for prenatal diagnosis. The extent of skin and mucosal lesions varies greatly depending on EB subtype and patient age. In the more severe EB subtypes lifelong generalized blistering, chronic ulcerations and scarring sequelae lead to multiorgan involvement, major morbidity and life-threatening complications. In the absence of a cure, patient management remains based on preventive measures, together with symptomatic treatment of cutaneous and extracutaneous manifestations and complications. The rarity and complexity of EB challenge its appropriate care. Thus, the aim of the present study has been to generate multicentre, multidisciplinary recommendations on global skin care addressed to physicians, nurses and other health professionals dealing with EB, both in centres of expertise and primary care setting.MethodsAlmost no controlled trials for EB treatment have been performed to date. For this reason, recommendations were prepared by a multidisciplinary team of experts from different European EB centres based on available literature and expert opinion. They have been subsequently revised by a panel of external experts, using an online-modified Delphi method to generate consensus.ResultsRecommendations are reported according to the age of the patients. The major topics treated comprise the multidisciplinary approach to EB patients, global skin care including wound care, management of itching and pain, and early diagnosis of squamous cell carcinoma. Aspects of therapeutic patient education, care of disease burden and continuity of care are also developed.ConclusionThe recommendations are expected to be useful for daily global care of EB patients, in particular in the community setting. An optimal management of patients is also a prerequisite to allow them to benefit from the specific molecular and cell-based treatments currently under development.

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Crusted scabies in a girl with epidermolysis bullosa simplex

Cited by 19 publications

References 15 publications

Oral Ivermectin Treatment in Two Cases Of Scabies: Effective in Crusted Scabies Induced by Corticosteroid but Ineffective in Nail Scabies

Oral Ivermectin Treatment in Two Cases Of Scabies: Effective in Crusted Scabies Induced by Corticosteroid but Ineffective in Nail Scabies

Pruritic Crusted Scabies in an Immunocompetent Infant

Multicentre consensus recommendations for skin care in inherited epidermolysis bullosa

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