Crumbs proteins stabilize the cone mosaics of photoreceptors and improve vision in zebrafish

Hao, Qinlong; Zheng, Mingzhe; Weng, Kechao; Hao, Yumei; Zhou, Yao; Lin, Yuchen; Gao, Feng; Kou, Ziqi; Kawamura, Shoji; Yao, Ke; Xu, Pinglong; Chen, Jinghai; Zou, Jian

doi:10.1016/j.jgg.2020.12.002

Cited by 3 publications

(2 citation statements)

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“…The Crb2b knockout zebrafish line, crb2b ZJUKO201 , shows well-developed retinal lamination with proper localization of retinal cells and intact OLM [ 80 ]. The loss of Crb2b resulted in the ectopic expansion of Crb2a in the PRC IS in the planar plane and the gradual disruption of the cone mosaic accompanied by the elongated eye axis [ 80 ]. Crb proteins mediate cell–cell adhesion through their extracellular domains [ 36 ].…”

Section: Crb Structurementioning

confidence: 99%

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Diverse functions and pathogenetic role of Crumbs in retinopathy

Zhou,

Zhao,

Wang

et al. 2024

Cell Commun Signal

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The Crumbs protein (CRB) family plays a crucial role in maintaining the apical–basal polarity and integrity of embryonic epithelia. The family comprises different isoforms in different animals and possesses diverse structural, localization, and functional characteristics. Mutations in the human CRB1 or CRB2 gene may lead to a broad spectrum of retinal dystrophies. Various CRB-associated experimental models have recently provided mechanistic insights into human CRB-associated retinopathies. The knowledge obtained from these models corroborates the importance of CRB in retinal development and maintenance. Therefore, complete elucidation of these models can provide excellent therapeutic prospects for human CRB-associated retinopathies. In this review, we summarize the current animal models and human-derived models of different CRB family members and describe the main characteristics of their retinal phenotypes.

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Section: Crb Structurementioning

confidence: 99%

“…In wild-type retinas, Crb2b regulates the planar distribution of Crb2a and stabilizes the cone mosaic through heterophilic interactions (Crb2a–Crb2b). In contrast, either Crb2a or Crb2b can regulate homophilic interactions (Crb2a–Crb2a or Crb2b–Crb2b) when there is only one homolog [ 80 ].…”

Section: Crb Structurementioning

confidence: 99%