Crumbling under Pressure

BORC and BLOC-1: Shared Subunits in Trafficking Complexes

“…The identification of BORC also sheds light on the ambiguous observations in studies that focused on different BLOC-1 deletions, some of which reported embryonic lethality in mice (Zhang et al, 2014), whereas others just coat color changes (Dell'Angelica, 2004). Because three subunits are shared between BORC and BLOC-1, loss of any shared components will likely result in mislocalization and possibly, as observed for yeast BLOC-1 (John Peter et al, 2013), disassembly of both complexes and hence a stronger phenotype.…”