Crucial Role of Transient Receptor Potential Ankyrin 1 and Mast Cells in Induction of Nonallergic Airway Hyperreactivity in Mice

Hox, Valérie; Vanoirbeek, Jeroen; Alpízar, Yeranddy A.; Voedisch, Sabrina; Callebaut, Ina; Bobic, Sonja; Sharify, Ali; Vooght, Vanessa De; Gerven, Laura Van; Devos, Fien; Liston, Adrian; Voets, Thomas; Vennekens, Rudi; Bullens, Dominique; Vries, Annick de; Hoet, Peter; Braun, Armin; Ceuppens, Jan L.; Talavera, Karel; Nemery, Benoît; Hellings, Peter W.

doi:10.1164/rccm.201208-1358oc

Cited by 89 publications

(78 citation statements)

References 47 publications

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“…A recent study using an ovalbumin mouse model reported that inhalation of hyphochlonite [CID (2)] induced nonallergic lung hypersensitivity, an effect absent in ankyrin 1-null mice or W/W v MC-deficient mice (Hox et al, 2013). These results are interesting in view of the fact that ankyrin 2 was strongly associated with autism (De Rubeis et al, 2014;Iossifov et al, 2014).…”

Section: Functional and Pathologic Features Of Il-33 In Allergic Disementioning

confidence: 89%

Targeting IL-33 in Autoimmunity and Inflammation

Theoharides

Petra

Taracanova

et al. 2015

J Pharmacol Exp Ther

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Section: Functional and Pathologic Features Of Il-33 In Allergic Disementioning

confidence: 89%

Targeting IL-33 in Autoimmunity and Inflammation

Theoharides

Petra

Taracanova

et al. 2015

J Pharmacol Exp Ther

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“…Elevation of tracheal temperature by humidified warm air induced bronchospasms in ovalbumin-sensitized rats, and this response was abolished by NK1R and NK2R antagonists (71). In another study, it was shown that hypochlorite-ovalbumin-induced hypersensitivity was not induced in TRPA1 knockout mice (72). These reports imply that TRPA1 and bronchopulmonary vagal C-fibers releasing SP and NKA are key mediators of airway hypersensitivity in asthma.…”

Section: Role Of Tks In Hypersensitivity and Inflammation In Airwaymentioning

confidence: 94%

Tachykinin: recent developments and novel roles in health and disease

Onaga

2014

Biomolecular Concepts

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Over 80 years has passed since the discovery of substance P (SP), and a variety of peptides of the tachykinin (TK) family have been found and investigated. SP, neurokinin A (NKA), and neurokinin B (NKB) are representative peptides in mammalian species. SP and NKA are major excitatory neurotransmitters in the peripheral nervous system, while NKB is primarily involved in the central nervous system (CNS). Moreover, TK peptides play roles not only as neurotransmitters but also as local factors and are involved in almost all aspects of the regulation of physiological functions and pathophysiological processes. The role of SP as a mediator of pain processing and inflammation in peripheral tissues in coordination with transient receptor potential channels is well established, while novel aspects of TKs in relation to hematopoiesis, venous thromboembolism, tendinopathy, and taste perception have been clarified. In the CNS, the NKB signaling system in the hypothalamus has been shown to play a crucial role in the regulation of gonadotropin hormone secretion and the onset of puberty, and molecular biological studies have elucidated novel prophylaxic activities of TKs against neurogenic movement disorders based on their molecular structure. This review provides an overview of the novel aspects of TKs reported around the world in the last 5 years, with particular focus on nociception, inflammation, hemopoiesis, gonadotropin secretion, and CNS diseases.

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“…Interestingly, a role for TRPA1 has also been proposed in nonallergic inflammation in a study set up in a murine model which aimed to recapitulate incidents of AHR experienced by swimmers due to increased exposure to hypochlorite. The authors proposed that the AHR following exposure to hypochlorite and ovalbumin depends on a neuroimmune interaction that involves TRPA1-dependent stimulation of sensory neurons and mast cell activation, although the rationale is not obvious given AHR to direct contractile agents is not thought to have a neuronal component as they are thought to activate airway smooth muscle directly [125]. Another article by the same authors demonstrated that TRPA1, TRPV1 and mast cells play an indispensable role in the development of TDI-elicited AHR [126].…”

Section: Trpa1mentioning

confidence: 99%

The emerging role of transient receptor potential channels in chronic lung disease

Belvisi

Birrell

2017

Eur Respir J

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Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis are a major and increasing global health burden with a high unmet need. Drug discovery efforts in this area have been largely disappointing and so new therapeutic targets are needed. Transient receptor potential ion channels are emerging as possible therapeutic targets, given their widespread expression in the lung, their role in the modulation of inflammatory and structural changes and in the production of respiratory symptoms, such as bronchospasm and cough, seen in chronic lung disease.

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Crucial Role of Transient Receptor Potential Ankyrin 1 and Mast Cells in Induction of Nonallergic Airway Hyperreactivity in Mice

Abstract: Induction of AHR by exposure to ClO(-)-OVA depends on a neuroimmune interaction that involves TRPA1-dependent stimulation of sensory neurons and mast cell activation.

Cited by 89 publications

References 47 publications

Targeting IL-33 in Autoimmunity and Inflammation

Targeting IL-33 in Autoimmunity and Inflammation

Tachykinin: recent developments and novel roles in health and disease

The emerging role of transient receptor potential channels in chronic lung disease

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