Crucial Role of Insulin in Leptin Maintenance. Profound Decrease in Serum Leptin by Octreotide Acetate in Insulinoma Subjects.

Nakamura, Tomoatsu; Nagasaka, Shoichiro; Ishikawa, San‐e; Nonaka, Mutsuko; Fujibayashi, Kazutoshi; Saitô, Takako; Kusaka, Ikuyo; Higashiyama, Minori; Saito, Toshikazu

doi:10.1507/endocrj.47.359

Cited by 9 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although, we did not measure serum insulin levels, Stratton et al [2] reported that increments in leptin levels between day 0 and day + 1 were significantly related to the increase in insulin levels. Nakamura et al [19] demonstrated close association between insulin and leptin levels (r=0.899) in a patient, which were simultaneously measured during the baseline period by octreotide acetate treatment before and after resection of insulinoma. Increased serum insulin levels may thus be responsible for the increase in circulating leptin levels.…”

Section: Discussionmentioning

confidence: 97%

Perioperative Changes in Circulating Leptin Levels in Women Undergoing Total Abdominal Hysterectomy.

2001

View full text Add to dashboard Cite

Abstract.To investigate the effects of total abdominal hysterectomy on circulating leptin levels, 16 pre-and 8 postmenopausal patients with uterine leiomyoma or carcinoma in situ of the uterine cervix were enrolled. Serum levels of leptin and fasting blood sugar (FBS) were determined before (day -7) and after surgery (day +1 and +7). Body mass index (BMI) was recorded at day -7 and +7. Anesthesia duration, surgical duration, hematology, and blood loss during surgery were recorded. Relations of these variables to serum leptin levels were investigated. Serum leptin levels rose from 7.3 ±4.7 ng/mL to 9.3 ±5.8 ng/mL at day + 1 (P<0.01), then decreased to 4.9±3.0 ng/mL at day +7 (P< 0.05 vs. values at day -7 and +1). FBS levels also rose from 89.4± 7.5 mg/dL to 119.3±24.0mg /dL (P<0.01), then returned to normal at day +7 (96.2±9.0 mg/dL).However, there was no significant correlation observed between FBS and leptin levels at each time point (r<0.22).BMI decreased from 22.7±3.0 kg/m2 to 21.7 ±2.9 kg/m2 at day + 7 (P< 0.001). At day -7 and +7, leptin levels were positively correlatd with BMI (r= 0.79, P<0.001 and r=0.71, P<0.001, respectively).Circulating leptin levels were increased on day one after total abdominal hysterectomy.

show abstract

Section: Discussionmentioning

confidence: 97%

Perioperative Changes in Circulating Leptin Levels in Women Undergoing Total Abdominal Hysterectomy.

2001

View full text Add to dashboard Cite

show abstract

“…Ahren and Havel [31] reported that leptin inhibited insulin secretion in an in vitro study. Moreover, Nakamura et al [32,33] showed that insulin plays a crucial role in the maintenance of leptin secretion in humans. Our data support these results.…”

Section: Discussionmentioning

confidence: 99%

Plasma Leptin Concentration in Tamoxifen-Treated Ovariectomized Rats

Hozumi¹,

Hakamata

Nagai³

2005

Gynecol Obstet Invest

View full text Add to dashboard Cite

Leptin, the ob gene product, has an important role in the regulation of body weight. Although tamoxifen, a nonsteroidal antiestrogenic agent, is known to have estrogenic effects on fat metabolism, its influence on adipose tissue remains unknown. In the present study, the effect of tamoxifen on the concentration of leptin was investigated in ovariectomized rats treated with tamoxifen or vehicle. The dosage of tamoxifen was extrapolated from the human dosage. Food intake, adipose tissue weight, and plasma insulin were assessed at the end of the experiment. Results: Tamoxifen-treated rats showed a significant reduction of body weight gain, food intake, adipose tissue weight and leptin concentration (p < 0.001). The plasma insulin level was significantly higher after tamoxifen treatment (p = 0.01) in tamoxifen-treated rats than in control rats. We concluded that tamoxifen reduces food intake in the acute phase and a reduction of adipose tissue gain may result in reduced levels of plasma leptin in ovariectomized rats. Furthermore, rats treated with tamoxifen may be resistant to insulin action.

show abstract

“…The function of SRIF receptors on adipocytes remains unknown. In vivo studies have demonstrated lowering of leptin levels by infusion of SRIF (50) and octreotide (51), an sst 2 /sst 5 -selective SRIF agonist; it is possible that SRIF regulates leptin secretion directly. We have detected sst 5 expression in perigonadal adipocyterich tissue isolated from WT mice and in 3T3-L1 adipocytes by RT-PCR.…”

Section: Fig 8 Changes In Insulin Sensitivity In Wt and Sst 5 Ko MImentioning

confidence: 99%

Somatostatin Receptor Subtype 5 Regulates Insulin Secretion and Glucose Homeostasis

Strowski¹,

Köhler²,

Chen³

et al. 2003

Molecular Endocrinology

117

View full text Add to dashboard Cite

Somatostatin (SRIF) regulates pancreatic insulin and glucagon secretion. In the present study we describe the generation of SRIF receptor subtype 5 knockout (sst(5) KO) mice to examine the role of SRIF receptor subtypes (sst) in regulating insulin secretion and glucose homeostasis. Mice deficient in sst(5) were viable, fertile, appeared healthy, and displayed no obvious phenotypic abnormalities. Pancreatic islets isolated from sst(5) KO mice displayed increased total insulin content as compared with islets obtained from wild-type (WT) mice. Somatostatin-28 (SRIF-28) and the sst(5)/sst(1)-selective agonist compound 5/1 potently inhibited glucose-stimulated insulin secretion from WT islets. SRIF-28 inhibited insulin secretion from sst(5) KO islets with 16-fold less potency while the maximal effect of compound 5/1 was markedly diminished when compared with its effects in WT islets. sst(5) KO mice exhibited decreased blood glucose and plasma insulin levels and increased leptin and glucagon concentrations compared with WT mice. Furthermore, sst(5) KO mice displayed decreased susceptibility to high fat diet-induced insulin resistance. The results of these studies suggest sst(5) mediates SRIF inhibition of pancreatic insulin secretion and contributes to the regulation of glucose homeostasis and insulin sensitivity. Our findings suggest a potential beneficial role of sst(5) antagonists for alleviating metabolic abnormalities associated with obesity and insulin resistance.

show abstract

Crucial Role of Insulin in Leptin Maintenance. Profound Decrease in Serum Leptin by Octreotide Acetate in Insulinoma Subjects.

Cited by 9 publications

References 20 publications

Perioperative Changes in Circulating Leptin Levels in Women Undergoing Total Abdominal Hysterectomy.

Perioperative Changes in Circulating Leptin Levels in Women Undergoing Total Abdominal Hysterectomy.

Plasma Leptin Concentration in Tamoxifen-Treated Ovariectomized Rats

Somatostatin Receptor Subtype 5 Regulates Insulin Secretion and Glucose Homeostasis

Contact Info

Product

Resources

About